DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIE and GLR2.2

DIOPT Version :9

Sequence 1:	NP_001036733.1	Gene:	GluRIIE / 318623	FlyBaseID:	FBgn0051201	Length:	897	Species:	Drosophila melanogaster
Sequence 2:	NP_180048.1	Gene:	GLR2.2 / 817008	AraportID:	AT2G24720	Length:	920	Species:	Arabidopsis thaliana

Alignment Length:	1003	Identity:	194/1003 - (19%)
Similarity:	374/1003 - (37%)	Gaps:	200/1003 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MFFNHFVILWSLFSIHISVNWAQYENFGGYDNYQSLESVPIGLLTDQNTEQMNIVFDHAIDVANQ 65
            :|| .|:.|:..|.:         |:..|.||.::  .|.||:::|..|...        |||..
plant     6 LFF-RFLFLFFFFCL---------ESSRGQDNGKT--QVNIGVVSDVGTSYP--------DVAML 50

  Fly    66 EVGTSLTSLKEE---------VNYGDAYQS-YGKLCRMLE----TGIAGVFGPSSRHTAVHLMSI 116
            .:..||......         ||.||:... .|.....::    ..:..:.||.:...|..|:.|
plant    51 CINMSLADFYSSRPQFQTRLVVNVGDSKNDVVGAATAAIDLIKNKQVKAILGPWTSMQAHFLIEI 115

  Fly   117 CDAMDIPHI-YSYMSENAEG------FNLHPHPADLAKALYSLITEFNWTRFIFLY-ESAEYLNI 173
            .....:|.: ||..|.:...      |......:....|:.::|..|.|...:.:| ::.....|
plant   116 GQKSRVPVVSYSATSPSLTSLRSPYFFRATYEDSSQVHAIKAIIKLFGWREVVPVYIDNTFGEGI 180

  Fly   174 LNELTTMLGKSGTVITVLRYDMQLNGNYKQVLRRVRK--SVDNRIVVVGSSETMPE--FLNQAQQ 234
            :..||..| :...|....|..:.||...:.:...:.|  ::..|:.:|..|.::..  |: :|::
plant   181 MPRLTDSL-QDINVRIPYRSVIPLNATDQDISVELLKMMNMPTRVFIVHMSSSLASTVFI-KAKE 243

  Fly   235 VGIINEDYKYIIGNLDFHSFDLEEYKYSEANITGLRLFSPEKMAVKELLMKLGYPT------DQD 293
            :|::...|.:|:.|               ..:.|||  |..:..::.:...||..|      |.:
plant   244 LGLMKPGYVWILTN---------------GVMDGLR--SINETGIEAMEGVLGIKTYIPKSKDLE 291

  Fly   294 EFRN------GSCPITVEMALTYDAVQLFAQTLKNLPFKPMPQNCSQRTESVRD-DGSSFKNYMR 351
            .||:      ....:.|.....|||....|..:::.....|..:.....::|.: ||.....:..
plant   292 TFRSRWKRRFPQMELNVYGLWAYDATTALAMAIEDAGINNMTFSNVDTGKNVSELDGLGLSQFGP 356

  Fly   352 TLRLTDRLLTGPIYFEGNVRKGYHLDVIELQPS----------GIVKVGTWDEDR------QYRP 400
            .|..|    ...:.|:| :...:|....:||||          |...:|.|.|..      ...|
plant   357 KLLQT----VSTVQFKG-LAGDFHFVSGQLQPSVFEIVNMIGTGERSIGFWTEGNGLVKKLDQEP 416

  Fly   401 QRLAPTTAQFDSVDN--------------SLANKTFIILLSVPNK-PYAQLVE-TYKQLEGNSQY 449
            :.:...:...|.:.:              .:......:.:.||.: .:..||: |...:..::..
plant   417 RSIGTLSTWPDHLKHIIWPGEAVSVPKGWEIPTNGKKLRIGVPKRIGFTDLVKVTRDPITNSTVV 481

  Fly   450 EGYGVDLIKELADKLGFNFTFVNGGNDYGSYNKSTNESTG----MLREIMTGRADLAITDLTITS 510
            :|:.:|..:.:...:.::.::     ::..:.|...|..|    ::.::..|:.|..:.|.||.:
plant   482 KGFCIDFFEAVIQAMPYDVSY-----EFFPFEKPNGEPAGNHNDLVHQVYLGQFDAVVGDTTILA 541

  Fly   511 EREQALDFTIPFMNLGIAILYLKPQKATPELFTFMDPFSEEVW-WFLGFSFLGVSLSFFILGRLS 574
            .|...:|||:|||..|:.::.....:...:.|:|:.|.|.|:| ..|.|.|| |.:|.:.|....
plant   542 NRSSFVDFTLPFMKSGVGLIVPLKDEVKRDKFSFLKPLSIELWLTTLVFFFL-VGISVWTLEHRV 605

  Fly   575 PSEWDNPYPCIEEPEELENQFTLGNSIWFTTGALLQQGSEIGPK----ALSTRTVASFWWFFTLI 635
            .|::..|           ..:......||....::     ..|:    :...|::...|:|..|:
plant   606 NSDFRGP-----------ANYQASTIFWFAFSTMV-----FAPRERVLSFGARSLVVTWYFVLLV 654

  Fly   636 VVSSYTANLAAFLTIEKPQSLINSVDDLADNKDGVVY--------GAKKTGSTRNFFM--TSAEE 690
            :..||||:||:.||.::....|.|:..|....:.|.|        ...:||..::..:  .:|||
plant   655 LTQSYTASLASLLTSQQLNPTITSMSSLLHRGETVGYQRTSFILGKLNETGFPQSSLVPFDTAEE 719

  Fly   691 RYKKMNKFMSENPQYLTEDNMEGVNRVKTNTHYAFLMESTSIEYNTKRECN-LKKIGDALDEKGY 754
                .::.:.:.|:      ..||......|.|..|...   :|     || .|.:.:..:..|:
plant   720 ----CDELLKKGPK------NGGVAAAFLGTPYVRLFLG---QY-----CNTYKMVEEPFNVDGF 766

  Fly   755 GIAMRKDWPHRGKFNNALLELQEQGVLEKMKNKWWNEVGTGICATKEDAPDATPLDMNNLEGV-- 817
            |.......|.....:.|:|::.|.....::::.|:.:.... |......||:.|.......||
plant   767 GFVFPIGSPLVADVSRAILKVAESPKAVELEHAWFKKKEQS-CPDPVTNPDSNPTVTAIQLGVGS 830

  Fly   818 --FFVLLVGSCCALLYGIISWVLFVMKKAHHYRVPLRDALKEEFQFVIDFNNYVRVLKN---SAS 877
              |..|:|...|.|..|..::......|.       :|..||..:  .|.::|:..::.   |..
plant   831 FWFLFLVVFVVCVLALGKFTFCFLWKTKG-------KDLWKEFLK--RDTDSYINDIEKCLCSQE 886

  Fly   878 IYSRSRQSS--------MSVASVAQESQ 897
            :...|.:::        :.|.::.|.:|
plant   887 MPENSNKATNQTNYGMELRVRNIVQVNQ 914

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIE	NP_001036733.1	PBP1_iGluR_Kainate	42..396	CDD:107377	78/402 (19%)
		ANF_receptor	51..382	CDD:279440	67/369 (18%)
		PBP2_iGluR_Kainate	419..790	CDD:270432	80/392 (20%)
		Lig_chan	551..824	CDD:278489	61/292 (21%)
GLR2.2	NP_180048.1	PBP1_GABAb_receptor	33..412	CDD:107361	79/410 (19%)
		ANF_receptor	47..392	CDD:279440	70/368 (19%)
		HisJ	438..>587	CDD:223904	29/153 (19%)
		GluR_Plant	452..801	CDD:270404	79/388 (20%)
		Lig_chan	582..819	CDD:278489	56/272 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	137	1.000	Inparanoid score	I1813
OMA	1	1.010	-	-		QHG60082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm1027
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.930