DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIE and GLR2

DIOPT Version :9

Sequence 1:	NP_001036733.1	Gene:	GluRIIE / 318623	FlyBaseID:	FBgn0051201	Length:	897	Species:	Drosophila melanogaster
Sequence 2:	NP_001318239.1	Gene:	GLR2 / 816231	AraportID:	AT2G17260	Length:	925	Species:	Arabidopsis thaliana

Alignment Length:	915	Identity:	200/915 - (21%)
Similarity:	376/915 - (41%)	Gaps:	169/915 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 VPIGLLTDQNT---EQMNIVFDHAIDVANQEV----GTSLTSLKEEVNYGDAYQSYGKLCRMLET 96
            :.:|.:...||   |..||.|..|.:..|.:.    |:.|..|..:..........|.| :.:||
plant    34 IKVGAIFGLNTMYGETANIAFKAAEEDVNSDPSFLGGSKLRILMNDAKRSGFLSIMGAL-QFMET 97

  Fly    97 GIAGVFGPSSRHTAVHLMSICDAMDIPHIYSY------MSENAEGFNLHPHPAD--LAKALYSLI 153
            .:..:.||.:...|..|..:.:.:.:| :.|:      :|.....|.:...|:|  |.:|:..:|
plant    98 DVVAIIGPQTSIMAHVLSHLANELTVP-MLSFTALDPTLSPLQFPFFVQTAPSDLFLMRAIAEMI 161

  Fly   154 TEFNWTRFIFLYESAEYLNILNELTTM---LGKSGTVIT---VLRYDMQLNGNYKQVLRRVR-KS 211
            |.:.|:..:.||...:  |..|.:|.:   |.:....|:   ||..|:.:....:.:...:: :.
plant   162 TYYGWSDVVALYNDDD--NSRNGVTALGDELEERRCKISYKAVLPLDVVITSPVEIIEELIKIRG 224

  Fly   212 VDNRIVVVGSSETMPE----FLNQAQQVGIINEDYKYII---------GNLDFHSFDLEEYKYSE 263
            :::|::||   .|.|.    ...:|:::|::.:.|.:|.         .||..      :.|...
plant   225 MESRVIVV---NTFPNTGKMIFKEAERLGMMEKGYVWIATTWLSSVLDSNLPL------DTKLVN 280

  Fly   264 ANITGLRLFSPEKMAVKELLM----KLGYPTDQDEFRNGSCPITVEMALTYDAVQLFAQTLK--- 321
            ..:| |||.:|:....::...    ||.        .|.:..:.|.....||.|.:.|:.:|
plant   281 GVLT-LRLHTPDSRKKRDFAARWKNKLS--------NNKTIGLNVYGLYAYDTVWIIARAVKTLL 336

  Fly   322 ----NLPFKPMPQNCSQRTESVR-------DDGSSFKNYMRTLRLTDRLLTGPIYFEGN---VRK 372
                ||.|....:..|.:.|::.       |.||...:|:...:::.  ||||:.|..:   ::.
plant   337 EAGGNLSFSNDAKLGSLKGEALNLSALSRFDQGSQLLDYIVHTKMSG--LTGPVQFHPDRSMLQP 399

  Fly   373 GYHLDVIELQPSGIVKVGTWD----------EDRQYRPQRLAPTTAQFDSV----DNSLANKTFI 423
            .|  |:|.|....:.::|.|.          |....:|...:.:....:||    ..|:..:.:|
plant   400 SY--DIINLVDDRVHQIGYWSNYSGLSIVPPESFYSKPPNRSSSNQHLNSVTWPGGTSVTPRGWI 462

  Fly   424 -------ILLSVPNKPYAQLVETYKQLEGNS-QYEGYGVDL----IKELADKLGFNFTFVNGGND 476
                   :.:.||::  |...:...::.|:| :.:||.:|:    :|.|:..:...|.|...|..
plant   463 FRNNGRRLRIGVPDR--ASFKDFVSRVNGSSNKVQGYCIDVFEAAVKLLSYPVPHEFIFFGDGLT 525

  Fly   477 YGSYNKSTNESTGMLREIMTG-RADLAITDLTITSEREQALDFTIPFMNLGIAILYLKPQKATPE 540
            ..:||:..|:.|       || ..|..:.|:.|.::|.:.:|||.|::..|:.:: ....:....
plant   526 NPNYNELVNKVT-------TGVDFDAVVGDIAIVTKRTRIVDFTQPYIESGLVVV-APVTRLNEN 582

  Fly   541 LFTFMDPFSEEVWWFLGFSFLGVSLSFFILGRLSPSEWDNPYPCIEEPEELENQFTLGNSIWFTT 605
            .:.|:.||:..:|......|:.|..:.:||......|:..|      |..     .:...:|||.
plant   583 PWAFLRPFTLPMWAVTASFFVIVGAAIWILEHRINDEFRGP------PRR-----QIITILWFTF 636

  Fly   606 GALLQQGSEIGPKALSTRTVASFWWFFTLIVVSSYTANLAAFLTIEKPQSLINSVDDLADNKDGV 670
            ..:.....|.....|. |.|...|.|..||:.|||||:|.:.||:::..|.|..||.|..:...:
plant   637 STMFFSHRETTVSTLG-RMVLLIWLFVVLIITSSYTASLTSILTVQQLNSPIKGVDTLISSTGRI 700

  Fly   671 VYGAKKTGSTRNFFMTS----AEERYKKMNKFMSENPQYLTEDNMEGVNRVKTNTHYAFLMESTS 731
            .:   :.||....:||.    |..|...:     .:|:       |..|.::..|..|.:.|...
plant   701 GF---QVGSFAENYMTDELNIASSRLVPL-----ASPE-------EYANALQNGTVAAIVDERPY 750

  Fly   732 IEYNTKRECNLKKIGDALDEKGYGIAMRKDWPHRGKFNNALLELQEQGVLEKMKNKWWNEVGTGI 796
            |:......|.....|......|:|.|..:|.|.....:.|:|.|.|.|.|:|:.::|.::..
plant   751 IDLFLSDYCKFAIRGQEFTRCGWGFAFPRDSPLAVDMSTAILGLSETGELQKIHDRWLSKSN--- 812

  Fly   797 CATK--EDAPDATPLDMNNLEGVFFVLLVGSCCALLYGIISWVLFVMKKAHHYRVPLRDALKEEF 859
            |::.  ..:.|:..|::::..|:|  |:||..|.:       .||:    |.::: :||..|:..
plant   813 CSSPHGSQSGDSEQLNVHSFWGMF--LVVGIACLV-------ALFI----HFFKI-IRDFCKDTP 863

  Fly   860 QFVID 864
            :.|::
plant   864 EVVVE 868

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIE	NP_001036733.1	PBP1_iGluR_Kainate	42..396	CDD:107377	88/419 (21%)
		ANF_receptor	51..382	CDD:279440	80/383 (21%)
		PBP2_iGluR_Kainate	419..790	CDD:270432	92/387 (24%)
		Lig_chan	551..824	CDD:278489	66/278 (24%)
GLR2	NP_001318239.1	PBP1_GABAb_receptor	35..424	CDD:107361	87/414 (21%)
		GluR_Plant	468..808	CDD:270404	90/376 (24%)
		Lig_chan	594..843	CDD:306551	68/280 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm1027
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.780