DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GluRIIE and gria1a

DIOPT Version :9

Sequence 1:	NP_001036733.1	Gene:	GluRIIE / 318623	FlyBaseID:	FBgn0051201	Length:	897	Species:	Drosophila melanogaster
Sequence 2:	NP_991161.1	Gene:	gria1a / 798689	ZFINID:	ZDB-GENE-020125-1	Length:	914	Species:	Danio rerio

Alignment Length:	896	Identity:	285/896 - (31%)
Similarity:	449/896 - (50%)	Gaps:	121/896 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 NFGGYDNYQSLESVPIGLLTDQNTEQMNIVFDHAIDVANQEVGTSLTSLKEEVNYGDAYQSYGKL 90
            |.||....:|.|           .|.......|..|:      ..|....:.|..|:::......
Zfish    26 NIGGLFPTESHE-----------YEVFRFALSHHQDI------PKLVPQVDMVKLGNSFSMTYAF 73

  Fly    91 CRMLETGIAGVFGPSSRHTAVHLMSICDAMDIPHIY-SYMSENAEGFNLHPHPADLAKALYSLIT 154
            |.....|:..:.|...|.|...|||.|.|:.:..:. |:..||:..|.:...| :|..||..:|.
Zfish    74 CSQFSKGVYAIIGVYDRKTVNMLMSFCGALHVCFVTPSFPMENSNQFVIQLRP-ELQDALVGVIE 137

  Fly   155 EFNWTRFIFLYESAEYLNILNELTTMLGKSGTVITVLRYDMQLNGNYKQVLRRVRKSVDNRIVVV 219
            .:.|::|:::|.|...|::|.::.....:...::|.:..:.....::.:|.:.:.|..:.:|::.
Zfish   138 HYRWSKFVYMYSSDSGLSVLQKVLDTAAEHNWLVTSVNVETMTEASFLKVFQDLDKKKEGQIIID 202

  Fly   220 GSSETMPEFLNQAQQVGIINEDYKYIIGNLDFHSFDLEEYKYSEANITGLRLFS---PEKMAVKE 281
            ...|.:...|.:..::|...:.|.||:.||.|...||.|:|..|||:||.:|.:   |......:
Zfish   203 CELERLTSILKKIIELGKNVKSYHYILANLGFLDIDLTEFKKGEANVTGFQLVNYADPNVSRTVQ 267

  Fly   282 LLMKLGYPTDQDEFRNGSCPITVEM-----ALTYDAVQLFAQTLKNL------------------ 323
            ..|         ||.|....:....     |||||.|::.:...:||
Zfish   268 QWM---------EFDNKDAKVPKRRLKYTGALTYDGVKVMSTAFQNLRRQRIDISRRGNAGECLA 323

  Fly   324 -PFKPMPQNCS-QRT-ESVRDDGSSFKNYMRTLRLTDRLLTGPIYF-EGNVRKGYHLDVIELQPS 384
             |..|..|... ||. :.||.:|                |||.|.| |...|..|.:.|:||:|:
Zfish   324 NPPAPWGQGIDIQRALQQVRIEG----------------LTGHIQFNEKGRRTNYSISVMELRPT 372

  Fly   385 GIVKVGTWDEDRQYRPQRLAPTTAQFDSVDN---SLANKTFIILLSVPNKPYAQLVETYKQLEGN 446
            |..|||.|:||.::      .:||.:....|   .|.|:|:|: .::...||..|.:.::...||
Zfish   373 GPKKVGYWNEDEKF------VSTAAYMPGSNETYGLQNRTYIV-TTILESPYVMLKKNHEHFTGN 430

  Fly   447 SQYEGYGVDLIKELADKLGFNFTF-VNGGNDYGSYNKSTNESTGMLREIMTGRADLAITDLTITS 510
            .:||||.|:|..|:|..:|:::.. :.....||:.:..|....||:.|::.|:||:|:..||||.
Zfish   431 DKYEGYCVELAAEIAKHVGYHYILKIVADGKYGARDAETMMWNGMVGELVYGKADVAVAPLTITL 495

  Fly   511 EREQALDFTIPFMNLGIAILYLKPQKATPELFTFMDPFSEEVWWFLGFSFLGVSLSFFILGRLSP 575
            .||:.:||:.|||:|||:|:..||.|:.|.:|:|:||.:.|:|..:.|:::|||:..|::.|.||
Zfish   496 VREEVIDFSKPFMSLGISIMIKKPTKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSP 560

  Fly   576 SEW----------DNP-YPCI-------------EEPEELENQFTLGNSIWFTTGALLQQGSEIG 616
            .||          :|| .|..             ::.:|..|:|.:.||:||:.||.:|||.:|.
Zfish   561 YEWHADDCEDGAEENPNQPSSSSAQPGQNQQNQNQQSQEQTNEFGIFNSLWFSLGAFMQQGCDIS 625

  Fly   617 PKALSTRTVASFWWFFTLIVVSSYTANLAAFLTIEKPQSLINSVDDLADNKDGVVYGAKKTGSTR 681
            |::||.|.|...|||||||::||||||||||||:|:..|.|.|.:|||...: :.||....|||:
Zfish   626 PRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTE-IAYGTLDAGSTK 689

  Fly   682 NFFMTSAEERYKKMNKFM-SENPQYLTEDNMEGVNRV-KTNTHYAFLMESTSIEYNTKRE-CNLK 743
            .||..|....::||..:| |.:|....:...|||.|| |:...||:|:|||..||..:|: |:..
Zfish   690 EFFRRSKIAVFEKMWSYMKSADPSVFVKTTDEGVMRVRKSKGKYAYLLESTMNEYIEQRKPCDTM 754

  Fly   744 KIGDALDEKGYGIAMRKDWPHRGKFNNALLELQEQGVLEKMKNKWW---NEVGTGICATKEDAPD 805
            |:|..||.||||||..|..|.|...|.|:|:|.|||:|:|:|||||   .|.|:|    ..|:.|
Zfish   755 KVGGNLDSKGYGIATPKGSPLRNPVNLAVLKLNEQGLLDKLKNKWWYDKGECGSG----GGDSKD 815

  Fly   806 AT-PLDMNNLEGVFFVLLVGSCCALLYGIISWVLFVMKKAHHYRVPLRDAL 855
            .| .|.::|:.|||::|:.|...|:|..::.:......::...:..:.||:
Zfish   816 KTSALSLSNVAGVFYILIGGLGLAMLVALVEFCYKSRTESRRMKQSINDAM 866

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIE	NP_001036733.1	PBP1_iGluR_Kainate	42..396	CDD:107377	93/384 (24%)
		ANF_receptor	51..382	CDD:279440	84/361 (23%)
		PBP2_iGluR_Kainate	419..790	CDD:270432	165/401 (41%)
		Lig_chan	551..824	CDD:278489	127/303 (42%)
gria1a	NP_991161.1	Periplasmic_Binding_Protein_Type_1	26..387	CDD:299141	99/409 (24%)
		ANF_receptor	36..369	CDD:279440	85/375 (23%)
		PBP2_iGluR_AMPA_GluR1	404..806	CDD:270447	165/403 (41%)
		Lig_chan	536..836	CDD:278489	127/304 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591282
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.750