DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIE and Grid1

DIOPT Version :9

Sequence 1:	NP_001036733.1	Gene:	GluRIIE / 318623	FlyBaseID:	FBgn0051201	Length:	897	Species:	Drosophila melanogaster
Sequence 2:	NP_077354.1	Gene:	Grid1 / 79219	RGDID:	68366	Length:	1009	Species:	Rattus norvegicus

Alignment Length:	900	Identity:	225/900 - (25%)
Similarity:	398/900 - (44%)	Gaps:	140/900 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 VPIGLLTDQNTEQMNIVFDHAI-------DVANQEVGTSLTSLKEEVNYGDAYQSYGKLCRMLET 96
            :.||.:.::|..:.:.||..|:       |:...|   .:|...:.:...:.:|:..:.|.::..
  Rat    24 IHIGAIFEENAAKDDRVFQLAVSDLSLNDDILQSE---KITYSIKVIEANNPFQAVQEACDLMTQ 85

  Fly    97 GIAGVFGPSSRHTAVHLMSICDAMDIPHIYSYMSENAEG-----FNLHPHPADLAKALYS----- 151
            ||..:...:...:|..|.|:.|||.|||:  ::..|..|     .:|:|.|...|..|.|
  Rat    86 GILALVTSTGCASANALQSLTDAMHIPHL--FVQRNPGGSPRTACHLNPSPDGEAYTLASRPPVR 148

  Fly   152 -------LITEFNWTRFIFLYESAEYLNILNELTTMLGKSGTVITVLRYDMQLNGNYKQV----- 204
                   |:||..|.:|:..|:|...:..|........:.|..:::.:.|..::..:..:
  Rat   149 LNDVMLRLVTELRWQKFVMFYDSEYDIRGLQSFLDQASRLGLDVSLQKVDKNISHVFTSLFTTMK 213

  Fly   205 ---LRRVRKSVDNRIVVVGSSETMPEFLNQAQQVGIINEDYKYIIGNLDFHSFDLEEYKYSEANI 266
               |.|.|.:: .|.:::.|.:....|:|:|.:..:.::|..::..|        ||  .|:..|
  Rat   214 TEELNRYRDTL-RRAILLLSPQGAHSFINEAVETNLASKDSHWVFVN--------EE--ISDPEI 267

  Fly   267 TGLRLFSPEKMAVKELLMKLGYPTDQDE---FRNGS------CP--------ITVEMALTYDAVQ 314
            ..|...:..:|.|...:    :|:.:|.   .||..      |.        :.:.....||:|.
  Rat   268 LDLVHSALGRMTVVRQI----FPSAKDNQKCMRNNHRISSLLCDPQEGYLQMLQISNLYLYDSVL 328

  Fly   315 L----FAQTLKNLPFKPMPQ-NCSQRTESVRDDGSSFKNYMRTLRLTDRLLTGPIYFEGNVRKGY 374
            :    |.:.|::..:..|.. ||.:::....:.|.|..:.::...:|.  |||.:.|..:....|
  Rat   329 MLANAFHRKLEDRKWHSMASLNCIRKSTKPWNGGRSMLDTIKKGHITG--LTGVMEFREDSSNPY 391

  Fly   375 -HLDVI-----ELQPSGIVKVGTWDEDR------QYRP--QRLAPTTAQFDSVDNSLANKTFIIL 425
             ..:::     |.....:.|:.|||.::      |.||  .||...|.:               :
  Rat   392 VQFEILGTTYSETFGKDMRKLATWDSEKGLNGSLQERPMGSRLQGLTLK---------------V 441

  Fly   426 LSVPNKPYAQLVETYKQLEGNSQYEGYGVDLIKELADKLGFNFTFVNGGND-YGS--YNKSTNES 487
            ::|..:|:..:.|..  |....:|:|:.:|::..||..|||.:......:. ||.  :|.|.|
  Rat   442 VTVLEEPFVMVAENI--LGQPKRYKGFSIDVLDALAKALGFKYEIYQAPDGRYGHQLHNTSWN-- 502

  Fly   488 TGMLREIMTGRADLAITDLTITSEREQALDFTIPFMNLGIAILYLKPQKATPELFTFMDPFSEEV 552
             ||:.|:::.||||||:.:|||.|||..:||:..:|:..:.||..||::.. .:|:...||...|
  Rat   503 -GMIGELISKRADLAISAITITPERESVVDFSKRYMDYSVGILIKKPEEKI-SIFSLFAPFDFAV 565

  Fly   553 WWFLGFSFLGVSLSFFILGRLS---PSEWDNPYPCIEEPEELENQFTLGNSIWFTTGALLQQGSE 614
            |..:..:...|.:..|:|.|:.   ......|.|....        ||.::||...||.:|||.|
  Rat   566 WACIAAAIPVVGVLIFVLNRIQAVRSQSATQPRPSASA--------TLHSAIWIVYGAFVQQGGE 622

  Fly   615 IGPKALSTRTVASFWWFFTLIVVSSYTANLAAFLTIEKPQSLINSVDDLADNKDGVVYGAKKTGS 679
            ....:::.|.|...||.|||||.||||||||||||:.:..|.:.:..||:...: :.||..:..:
  Rat   623 SSVNSVAMRIVMGSWWLFTLIVCSSYTANLAAFLTVSRMDSPVRTFQDLSKQLE-MSYGTVRDSA 686

  Fly   680 TRNFFMTSA------EERYKKMNKFMSEN--PQYLTEDNMEGVNRVKTNTHYAFLMESTSIEYN- 735
            ...:|....      :..:.::.:.:|:|  ......:..||:.:.|.. :||||.:...:||.
  Rat   687 VYEYFRAKGTNPLEQDSTFAELWRTISKNGGADNCVSNPSEGIRKAKKG-NYAFLWDVAVVEYAA 750

  Fly   736 -TKRECNLKKIGDALDEKGYGIAMRKDWPHRGKFNNALLELQEQGVLEKMKNKWWNEVGTGICAT 799
             |..:|::..||:::..||||||::...|:|..|:..:||||:.|.|:.:|.|||...|.....:
  Rat   751 LTDDDCSVTVIGNSISSKGYGIALQHGSPYRDLFSQRILELQDTGDLDVLKQKWWPHTGRCDLTS 815

  Fly   800 KEDA-PDATPLDMNNLEGVFFVLLVGSCCALLYGIISWVLFVMKKAHHYRVPLRD 853
            ...| .|...|.:::..|||.:|.:|...|.|...:.  |:......|...|..|
  Rat   816 HSSAQTDGKSLKLHSFAGVFCILAIGLLLACLVAALE--LWWNSNRCHQETPKED 868

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIE	NP_001036733.1	PBP1_iGluR_Kainate	42..396	CDD:107377	82/413 (20%)
		ANF_receptor	51..382	CDD:279440	76/390 (19%)
		PBP2_iGluR_Kainate	419..790	CDD:270432	120/386 (31%)
		Lig_chan	551..824	CDD:278489	87/286 (30%)
Grid1	NP_077354.1	Interaction with CBLN1. /evidence=ECO:0000250\|UniProtKB:Q61627	21..436		88/433 (20%)
		PBP1_iGluR_delta_1	25..423	CDD:107387	83/419 (20%)
		ANF_receptor	41..400	CDD:279440	74/380 (19%)
		PBP2_iGluR_delta_1	436..806	CDD:270448	121/400 (30%)
		Lig_chan	564..841	CDD:278489	87/286 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	931..960
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910