Protein Alignment GluRIIE and grin1

DIOPT Version :10

• Sequence 1: NP_001036733.1
• Gene: GluRIIE / 318623
• FlyBaseID: FBgn0051201
• Length: 897
• Species: Drosophila melanogaster
• Sequence 2: XP_012825220.1
• Gene: grin1 / 780048
• XenbaseID: XB-GENE-494200
• Length: 941
• Species: Xenopus tropicalis
• Alignment Length: 982
• Identity: 231/982 - (23%)
• Similarity: 396/982 - (40%)
• Gaps: 227/982 - (23%)

  Fly    39 VPIG-LLTDQNTEQMNIVFDHAIDVANQEVGT-----SLTSLKEEVNYGDAYQSYGKLCR-MLET 96
            |.|| :|:.:..||   :|..|::.||:..||     :.||:....|   |.|....:|. ::.:
 Frog    27 VNIGAVLSTKKHEQ---IFREAVNQANKRHGTWKIQLNATSVTHRPN---AIQMALSVCEDLISS 85

  Fly    97 GIAGVF-----GPSSRHTAVHLMSICDAMDIP--------HIYSYMSENAEGFNLHPHPADLAKA 148
            .:..:.     .|:...|...:........||        .|||..|.:.......|..:..|..
 Frog    86 QVYAILVSHPPAPTDHLTPTPISYTAGFYRIPVIGLTTRMSIYSDKSIHLSFLRTVPPYSHQALV 150

  Fly   149 LYSLITEFNWTRFIFLY-ESAEYLNILNELTTMLGKSGTV--------ITVLRYDMQLNGNYKQV 204
            .:.::..|||...|.:. :..|......:|.|:|.:..:.        :..|.||.:......:|
 Frog   151 WFEMMRLFNWNHVILIVSDDHEGRAAQKKLETLLEEKESKSKKRNYENLDQLSYDNKRGPKADKV 215

  Fly   205 LR------------RVRKSVDNRIVVVGSSE-TMPEFLNQAQQVGIINEDYKYIIGNLDFHSFDL 256
            |:            ...|.::.|::::.:|| ........|..:.:....|.:::|..:.....|
 Frog   216 LQFEPGTKNLTALLLEAKELEARVIILSASEDDATAVYKSAAMLDMTGAGYVWLVGEREISGSAL 280

  Fly   257 EEYKYSEANITGLRLFSPEKMAVKELLMKLGYPTDQDEFRNGSCPITVEMALTYDAVQLFAQTLK 321
               :|:...|.||:|.:.                     :|.|..|:       |||.:.||.:.
 Frog   281 ---RYAPDGIIGLQLING---------------------KNESAHIS-------DAVAVAAQAIH 314

  Fly   322 NL----PFKPMPQNCSQRTESVRDDGSSFKNYMRTLRLTDRLLTGPIYF-EGNVRKGYHLDVIEL 381
            .|    .....|:.|...| ::...|..||..:.:.:..|. :||.|.| |...||..:..::.|
 Frog   315 ELFEMENITDPPRGCVGNT-NIWKTGPLFKRVLMSSKYPDG-VTGRIEFNEDGDRKFANYSIMNL 377

  Fly   382 QPSGIVKVG--------------TWDEDRQYRPQRLAPTTAQFDSVDNSLANKTFIILLSVPNKP 432
            |...:|:||              .|......|||....:|.              :.::::..:|
 Frog   378 QNRKLVQVGIFNGSHVIQNDRKIIWPGGETERPQGYQMSTR--------------LKIVTIHQEP 428

  Fly   433 YAQLVET----------------YKQLEGNSQYE-------------GYGVDLIKELADKLGFNF 468
            :..:..|                .|::..|...|             |:.:||:.:||.::  ||
 Frog   429 FVYVKPTMTDGTCREEYTINGDPIKKVICNGPNETIPGRPTVPQCCYGFCIDLLIKLAREM--NF 491

  Fly   469 TF----VNGGNDYGSY----NKSTNESTGMLREIMTGRADLAITDLTITSEREQALDFTIPFMNL 525
            |:    |..|. :|:.    |.:..|..||:.|:::|:||:.:..|||.:||.|.::|:.||...
 Frog   492 TYEVHLVADGK-FGTQERVNNSNKKEWNGMMGELLSGQADMIVAPLTINNERAQYIEFSKPFKYQ 555

  Fly   526 GIAILYLKPQKATPELFTFMDPFSEEVWWFLGFSFLGVSLSFFILGRLSP-------SEWDNPYP 583
            |:.|| :|.:.....|.:||.||...:|..:|.|...|::..::|.|.||       ||
 Frog   556 GLTIL-VKKEIPRSTLDSFMQPFQSTLWLLVGLSVHVVAVMLYLLDRFSPFGRFKVNSE------ 613

  Fly   584 CIEEPEELENQFTLGNSIWFTTGALLQQG-SEIGPKALSTRTVASFWWFFTLIVVSSYTANLAAF 647
                 ||.|:..||.:::||:.|.||..| .|..|::.|.|.:...|..|.:|:|:|||||||||
 Frog   614 -----EEEEDALTLSSAMWFSWGVLLNSGIGEGAPRSFSARILGMVWAGFAMIIVASYTANLAAF 673

  Fly   648 LTIEKPQSLINSVDD--LADNKDGVVYGAKKTGSTRNFFMTSAE--ERYKKMNKFMSENPQYLTE 708
            |.:::|:..|..::|  |.:..|..:|...|..|...:|....|  ..|:.|.|       :..|
 Frog   674 LVLDRPEERITGINDPRLRNPSDKFIYATVKQSSVDIYFRRQVELSTMYRHMEK-------HNYE 731

  Fly   709 DNMEGVNRVKTNTHYAFLMESTSIEYNTKRECNLKKIGDALDEKGYGIAMRKDWPHRGKFNNALL 773
            ...|.:..|:.|..:||:.:|..:|:...::|:|...|:.....|:||.||||.|.:...:..:|
 Frog   732 SAAEAIQAVRDNKLHAFIWDSAVLEFEASQKCDLVTTGELFFRSGFGIGMRKDSPWKQNVSLNIL 796

  Fly   774 ELQEQGVLEKMKNKW--WNEVGTGICATKEDAPDATPLDMNNLEGVFFVLLVGSCCALLYGIISW 836
            :..|.|.:|::...|  :.|     |.::.:|| || |...|:.|||.::..|    ::.||...
 Frog   797 KSHENGFMEELDKTWVRYQE-----CDSRSNAP-AT-LTFENMAGVFMLVAGG----IVAGIFLI 850

  Fly   837 VLFVMKKAHHYRVPLRDALKEEFQFVIDFNNYVR-----------------------VLKNSASI 878
            .:.:..|.|      :||.:::.|......|..|                       :....||.
 Frog   851 FIEIAYKRH------KDARRKQMQLAFAAVNVWRKNLQDRKSGRAEPDPKKKASFRSITSTLASS 909

  Fly   879 YSRSRQS 885
            :.|.|.|
 Frog   910 FKRRRSS 916

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIE	NP_001036733.1	PBP1_iGluR_Kainate	40..402	CDD:380605	84/422 (20%)
		PBP2_iGluR_Kainate	419..790	CDD:270432	118/421 (28%)
		Lig_chan	551..824	CDD:459656	87/286 (30%)
grin1	XP_012825220.1	PBP1_iGluR_NMDA_NR1	25..404	CDD:380602	83/415 (20%)
		PBP2_iGluR_NMDA_Nr1	416..818	CDD:270437	120/442 (27%)
		CaM_bdg_C0	854..882	CDD:402271	7/33 (21%)