DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIE and grik5-like.1

DIOPT Version :9

Sequence 1:	NP_001036733.1	Gene:	GluRIIE / 318623	FlyBaseID:	FBgn0051201	Length:	897	Species:	Drosophila melanogaster
Sequence 2:	NP_001072565.1	Gene:	grik5-like.1 / 780020	XenbaseID:	XB-GENE-5860197	Length:	479	Species:	Xenopus tropicalis

Alignment Length:	441	Identity:	148/441 - (33%)
Similarity:	229/441 - (51%)	Gaps:	29/441 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   423 IILLSVPNKPYAQLVETYKQLEGNSQYEGYGVDLIKELADKLGFNFTF--VNGGNDYGSYNKSTN 485
            :.:.::..:|::...|        |..||:.:||:.|||..||||:|.  |..|. ||:.::..|
Frog    43 LTVTTIMEQPFSMKTE--------SGMEGFCIDLLSELAQSLGFNYTIKEVKDGR-YGAKDQDGN 98

  Fly   486 ESTGMLREIMTGRADLAITDLTITSEREQALDFTIPFMNLGIAILYLKPQ-KATPELFTFMDPFS 549
            .: ||:.|::...||||:..||||..||:.|.||.|||..||:||..|.. .....||.|:.|||
Frog    99 WN-GMVGEVLRKEADLAVAPLTITGARERELAFTKPFMQTGISILLRKDDVSENSYLFGFLTPFS 162

  Fly   550 EEVWWFLGFSFLGVSLSFFILGRLSPSEWDNPYPCIEEPEELENQFTLGNSIWFTTGALLQQGSE 614
            :|.|..:..:::..||..|::|||||.||       .|....:|.|...||:||..||...||:|
Frog   163 KETWIGILVAYVVTSLCLFLVGRLSPCEW-------TELSTEQNNFNFLNSLWFGVGAFTLQGAE 220

  Fly   615 IGPKALSTRTVASFWWFFTLIVVSSYTANLAAFLTIEKPQSL-INSVDDLADNKDGVVYGAKKTG 678
            ..||::|.|.:|..||.|::::|::|.|:.||||..:..|:. |.:.:||. |:..:.:|...:.
Frog   221 PHPKSVSARIIAVIWWIFSIVLVAAYIASFAAFLNSDSMQTTNIQTFEDLV-NQRTLEFGTINSS 284

  Fly   679 STRNFFMTSAEERYKKMNKFMSE-NPQYLTEDNMEGVNRVKTNTHYAFLMESTSIEYNTKRECNL 742
            ||..||..|....|:.:.::|.: ..:.|.:...|||.||| .::||||.||...:....:.|:|
Frog   285 STFQFFKNSKNPTYRMIYEYMDKRKDELLVKSFAEGVRRVK-ESNYAFLGESVMQDIMVAKHCDL 348

  Fly   743 KKIGDALDEKGYGIAMRKDWPHRGKFNNALLELQEQGVLEKMKNKWWNEVGTGICATKEDAPDAT 807
            .:....:..:|||||...|.|.....:.|:||..|.|.:|.::.|||:..    |..|..| ...
Frog   349 VRAPQIIAGRGYGIAASLDSPLIKPLSVAILEQTESGNIEYLRKKWWDNT----CNMKRSA-GWN 408

  Fly   808 PLDMNNLEGVFFVLLVGSCCALLYGIISWVLFVMKKAHHYRVPLRDALKEE 858
            |:..:.|.|:|.:|.:|....::..::..||.....|...:.....|..||
Frog   409 PVQPHTLGGIFLILGIGLALGVIAALVELVLKARNNADQQKKSCCSAFSEE 459

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIE	NP_001036733.1	PBP1_iGluR_Kainate	42..396	CDD:107377
		ANF_receptor	51..382	CDD:279440
		PBP2_iGluR_Kainate	419..790	CDD:270432	132/371 (36%)
		Lig_chan	551..824	CDD:278489	91/274 (33%)
grik5-like.1	NP_001072565.1	PBP2_iGluR_non_NMDA_like	41..396	CDD:270403	132/371 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910