DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIE and grin2ab

DIOPT Version :9

Sequence 1:	NP_001036733.1	Gene:	GluRIIE / 318623	FlyBaseID:	FBgn0051201	Length:	897	Species:	Drosophila melanogaster
Sequence 2:	XP_009304490.1	Gene:	grin2ab / 570493	ZFINID:	ZDB-GENE-070424-223	Length:	1445	Species:	Danio rerio

Alignment Length:	984	Identity:	214/984 - (21%)
Similarity:	411/984 - (41%)	Gaps:	214/984 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 VILWSLFSIHISVNWAQYENFGGYDNYQSLESVPIGLLTDQNTEQMNIVFDHAIDVANQEVGTSL 71
            ::||:|              .||....:...|:.|.::..|..    .|.:.|:..| :.:|..|
Zfish     9 MVLWAL--------------LGGSQAAEKPPSLSIAVILGQTP----TVSESALRPA-RGIGAPL 54

  Fly    72 --TSLKEEVNYGDAYQSYGKLCRMLET----GIAGVFGPSSRHTAVHLM----SICDAMDIPHIY 126
              |.|..:||..|.......||.::..    |:  |:|..:...||..|    |...:|.|..|:
Zfish    55 DVTVLSIQVNQTDPGSMLTHLCELMSRQRLHGL--VYGDGTDQEAVAQMLDFVSSQTSMPILGIH 117

  Fly   127 S----YMSENAEGFNLHPHPADL---AKALYSLITEFNWTRFIFLYESAEYLNILNELTTMLGKS 184
            .    .|:|.....:.....|.|   |..:.:::.|::|  .:|...:.::......:.|:.
Zfish   118 GGSAMTMAEKDSSSSFFQFGASLQQEALLMLAIMEEYDW--HVFSVVTTKFPGFQEFIATVR--- 177

  Fly   185 GTVITV----LRYDMQ----LNG------NYKQVLRRVRKSVDNRIVVVGSSETMPEFLNQAQQV 235
               :||    :|:|:|    |:|      .....|:|::..|   |::..|.:.....:.:|:.:
Zfish   178 ---VTVDHSFVRWDLQSVVTLDGVGEPEDRAHVQLKRIQSPV---ILLYCSKDEAALVMEEARSL 236

  Fly   236 GIINEDYKYIIGNLDFHSFDLEEYKYSEANITGLRLFSPEKMAVKELLMKLGYPTDQDEFRNGSC 300
            |:....:.:|:.:|                .||.....||  |....::.:.|    ||:   ..
Zfish   237 GLTGAGFVWIVPSL----------------TTGNLEHIPE--AFPAGMISVTY----DEW---DY 276

  Fly   301 PITVEMALTYDAVQLFAQTLKNLPFKP---MPQ---NCSQRTESVRDDGSSFKNYMRTLRLTDRL 359
            |:...:   .|||.:.:.....: |:.   :|.   :|..::|......|:.:.||..:.|
Zfish   277 PLETRL---QDAVGIISSAAAAM-FREEGRIPDGTASCYGQSEKPEVPPSALRRYMMGVNL---- 333

  Fly   360 LTGPIYFEGNVRKGYHLDVIELQPSGIV----------KVGTWDEDRQYRPQRLAPTTAQFDSVD 414
                    |.....:..|..::.|..:|          |:|.| |:...|.:  .|...:::|..
Zfish   334 --------GGKDHSFMDDGYQVNPKLVVIVLNTEREWEKMGRW-ENHSLRLK--FPVWPRYNSFG 387

  Fly   415 NSLANKTFIILLSVPNKPYA--------------QLVETYKQLEGNS---QY-----EGYGVDLI 457
            :..|::..:.::::..:|:.              ..|...|.::.|:   .|     :|:.:|::
Zfish   388 DMDADENHLSIVTLEERPFVIVDDVDILTGTCMRNSVPCRKHIKDNTTEGSYVKKCCKGFCIDIL 452

  Fly   458 KELADKLGFNFTFVNGGNDYGSYNKSTNES-TGMLREIMTGRADLAITDLTITSEREQALDFTIP 521
            |::|..:.|.:......|  |.:.|..|.. .||:.|::..:|.:|:..|||..||.:|:||::|
Zfish   453 KKIARNVKFTYDLYLVTN--GKHGKKINNVWNGMVGEVVYKKAVMAVGSLTINEERSEAIDFSVP 515

  Fly   522 FMNLGIAILYLKPQKATPELFTFMDPFSEEVWWFLGFSFLGV-SLSFFILGRLSPSEWDNPYPCI 585
            |:..||::: :.....|.....|::|||..||..:....|.| :::.|:...:||..::......
Zfish   516 FVETGISVM-VSRSNGTVSPSAFLEPFSASVWVMMFVMLLIVTAIAVFLFEFISPLGFNRNLAQG 579

  Fly   586 EEPEELENQFTLGNSIWFTTGALLQQGSEI-GPKALSTRTVASFWWFFTLIVVSSYTANLAAFLT 649
            ::|.  ...||:|.::|...|.:......: .|:..:::.:.|.|.||.:|.::|||||||||:.
Zfish   580 KDPH--GPSFTIGKAVWLLWGLVFNNSVPVQNPRGTTSKFIVSVWAFFAVIFLASYTANLAAFMI 642

  Fly   650 IEKPQSLINSVDDLADNKDGVVY--------GAKKTGST-RNFFMTSAEERYKKMNKFMSENPQY 705
            .|:   .::.|..|:|.|....|        |....||| ||.     .:.|..|:::|   .:|
Zfish   643 QEE---FVDQVTGLSDRKFQSPYSYSPPFRFGTVPNGSTERNI-----RKNYPAMHQYM---VKY 696

  Fly   706 LTEDNMEGVNRVKTNTHYAFLMESTSIEYNTKRE--CNLKKIGDA--LDEKGYGIAMRKDWPHRG 766
            .....::.:..:||....||:.::..:.|...|:  |.|..||..  ....||||||:|....:.
Zfish   697 HQTGVVDALVSLKTGKLDAFIYDAAVLNYMAGRDDGCKLVTIGSGYIFATTGYGIAMQKGSYWKR 761

  Fly   767 KFNNALLELQEQGVLEKMKNKWWNEVGTGICATKEDAPDATPLDMNNLEGVFFVLLVGSCCALL- 830
            ..:.|:|.:...|.:|:::.:|.    ||||..:::...::.||::|:.|||::|......:|:
Zfish   762 LVDLAILGIIGDGEMEELEAQWL----TGICHNEKNEVMSSQLDVDNMAGVFYMLAAAMALSLIT 822

  Fly   831 ---------------YGIIS---WVLFVMKKA-----HHYRVPLRDALKEEFQFVIDFN---NYV 869
                           .|:.|   .:||.:.:.     |...:.|:.|.:      :||:   |.:
Zfish   823 FVWEHLFYWRLRYCFTGLCSGRPGILFTISRGIWSCIHGVHIELKKAPE------LDFSPQANML 881

  Fly   870 RVLKNSASI 878
            .:||::..|
Zfish   882 HLLKSAKEI 890

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIE	NP_001036733.1	PBP1_iGluR_Kainate	42..396	CDD:107377	76/400 (19%)
		ANF_receptor	51..382	CDD:279440	69/367 (19%)
		PBP2_iGluR_Kainate	419..790	CDD:270432	102/408 (25%)
		Lig_chan	551..824	CDD:278489	77/287 (27%)
grin2ab	XP_009304490.1	PBP1_iGluR_NMDA_NR2	25..382	CDD:107373	80/418 (19%)
		ANF_receptor	48..358	CDD:279440	68/363 (19%)
		PBP2_iGluR_NMDA_Nr2	393..790	CDD:270436	106/416 (25%)
		Lig_chan	544..816	CDD:278489	77/288 (27%)
		NMDAR2_C	827..1445	CDD:287527	13/70 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591277
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.840