DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIE and grin3ba

DIOPT Version :9

Sequence 1:	NP_001036733.1	Gene:	GluRIIE / 318623	FlyBaseID:	FBgn0051201	Length:	897	Species:	Drosophila melanogaster
Sequence 2:	XP_021323058.1	Gene:	grin3ba / 566411	ZFINID:	ZDB-GENE-070912-354	Length:	1118	Species:	Danio rerio

Alignment Length:	884	Identity:	194/884 - (21%)
Similarity:	346/884 - (39%)	Gaps:	163/884 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 SLTSLKEEVNYGDAYQSYGKLCR-MLETGIAGVFG-PSSRHTAVHLMSICDAMDIPHIYSYMSEN 132
            ||..|..|...||....:..:|: ::..|::.|.. |.|....:.:..:...::||.|  .:.|.
Zfish    82 SLEVLSREPLNGDPESMFRCVCQDIVVQGVSAVLAFPQSHEELIQVEFMSSFLEIPFI--SIIEQ 144

  Fly   133 AE------GFNLH-----PHPADLAKALYSLITEFNWT-RFIFLYESAEYLNILNELTTM--LGK 183
            .|      .|:|.     | |:.|:..|.:::....|. ....:........:|.||...  ||.
Zfish   145 GEPLKTQNRFHLQMMTRMP-PSGLSDLLLAVLLRGGWQGGAATVCPGGGNTGMLEELQQRGHLGL 208

  Fly   184 SGT------VITVLRYDMQLNGN-----YKQVLRRVRKSVDNRIVVVGSS-ETMPEFLNQAQQVG 236
            .|.      .:.:.|.:..::.:     ..|:|.|...:..:.:|:.||. |.....|:.|.|:.
Zfish   209 DGAHWHLWETLNLSRLEENISEDKVMELLSQLLSRTPSAPASSVVLFGSDPECTATVLHCAHQLS 273

  Fly   237 IINEDYKYIIG---NLD-FHSF--DLEEYKYSEANITGLRLFSPEKMAVKELLMKLGYPTDQDEF 295
            .......:|:|   :|| .||.  .|....|.|.|...|..:      :::.|..:|...
Zfish   274 GTLPPMHWIMGYPLSLDSLHSIGSPLGLMAYGEVNRKPLNFY------IRDTLQLIGRAV----- 327

  Fly   296 RNGSCPITVEMALTYDAVQLFAQTLKN-LPFKPMPQNCSQRTESVRDDGSSFKNYMRTLRLTDRL 359
             ..:..:..::||..:.|..|.:..|: ||                ..|.....::.....|.
Zfish   328 -YAATMVRPDLALIQNMVNCFDKPNKHELP----------------SSGQYLARFLSNTSFTG-- 373

  Fly   360 LTGPIYFEGN-----VRKGYHLDVIELQPSG---IVKVGTWDEDR-QYRPQRLAPTTAQFDSVDN 415
            ||||:..|.:     ..:.:|:..::..|.|   .|.|.:|...| :...|.|.|...|....|.
Zfish   374 LTGPVRVERSFSRVLTSQRFHIWSLQRDPLGQPSWVTVASWQSGRLELEEQGLWPGVTQHQREDG 438

  Fly   416 -----------------------SLANKTFIILLSVPNK---PYAQLV------------ETYKQ 442
                                   :|....|:....|..:   |..||.            :.:::
Zfish   439 PGIRLGGRWQAGLPVAGSRLRVVTLVEHPFVFTREVDEEGQCPAGQLCLDPQTNNSEVLNQLFRE 503

  Fly   443 LEGNSQYE----------GYGVDLIKELADKLGFNF-TFVNGGNDYGSYNKSTNESTGMLREIMT 496
            ||..:...          ||.:||:::||:.:.|.| .::.|...||::  .....:|::.::::
Zfish   504 LEQTNSSSLPTDMRKCCYGYCIDLLEKLAEDMHFEFDLYIVGDGKYGAW--KGGRWSGLVGDLLS 566

  Fly   497 GRADLAITDLTITSEREQALDFTIPFMNLGIAILYLKPQKATPELFTFMDPFSEEVWWFLG-FSF 560
            |.||:|:|..:|.|.|.:.:|||.||.:..:.||......|.| :..||.|....:|  :| |..
Zfish   567 GVADMAVTSFSINSARSRVIDFTSPFFSTSLGILVRSKDTAAP-IGAFMWPLHWSMW--VGIFVA 628

  Fly   561 LGVSLSFFILGRLSPSEWDNPYPCIEEPEELENQFTLGNSIWFTTGALLQQGSEIG---PKALST 622
            |.::..|..|     .||::|:............|:..:::......|.  |..:.   ||..:.
Zfish   629 LHITALFITL-----YEWNSPFGMTPHGRNRIRVFSYSSALNLCYAILF--GRTVASKTPKCWTG 686

  Fly   623 RTVASFWWFFTLIVVSSYTANLAAFLTIEKPQSLINSVDD--LADNKDGVVYGAKKTGSTRNFFM 685
            |.:.:.|..|.|:|:|||||||||.:..||....::.:.|  |.....|..:|..:..|..::..
Zfish   687 RFLMNLWAIFCLLVLSSYTANLAAVMVGEKTFEEVSGIHDVKLHHPSLGFRFGTVRESSAEDYVK 751

  Fly   686 TSAEERYKKMNKFMSENPQYLTEDNMEGVNRVKTNTHY--AFLMESTSIEYNTK--RECNLKKIG 746
            .|..|.::.|.:|....    |.|   ||:.:||:...  ||:|:...::|...  .:|.|..:|
Zfish   752 KSFPEMHEYMRRFNKPT----TPD---GVSTLKTDPPQLDAFIMDKALLDYEVSIDADCKLLTVG 809

  Fly   747 DALDEKGYGIAMRKDWPHRGKFNNALLELQEQGVLEKMKNKWWNEV--GTGICATKEDAPDATPL 809
            .....:||||.:.::.|.....:..:...:..|.::.:.:||:..|  |..:.|..|    ...:
Zfish   810 KPFAIEGYGIGLPQNSPLTRNVSEYVSRYKSDGYMDMLHDKWYKVVPCGKRVFAVTE----TLQM 870

  Fly   810 DMNNLEGVFFVLLVGSCCAL--LYGIISWVLFVMKKAHH 846
            .:.:..|:|.:|.||...||  |.|..::..|::....|
Zfish   871 GIQHFSGLFVLLCVGVAGALLTLLGEHAFFRFILPHLRH 909

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIE	NP_001036733.1	PBP1_iGluR_Kainate	42..396	CDD:107377	73/368 (20%)
		ANF_receptor	51..382	CDD:279440	68/351 (19%)
		PBP2_iGluR_Kainate	419..790	CDD:270432	99/406 (24%)
		Lig_chan	551..824	CDD:278489	67/284 (24%)
grin3ba	XP_021323058.1	Periplasmic_Binding_Protein_Type_1	26..428	CDD:324556	76/378 (20%)
grin3ba	XP_021323058.1	PBP2_iGluR_NMDA_Nr3	457..852	CDD:270438	99/413 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591314
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.740