DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIE and grik1b

DIOPT Version :9

Sequence 1:	NP_001036733.1	Gene:	GluRIIE / 318623	FlyBaseID:	FBgn0051201	Length:	897	Species:	Drosophila melanogaster
Sequence 2:	XP_690040.5	Gene:	grik1b / 561540	ZFINID:	ZDB-GENE-070821-1	Length:	906	Species:	Danio rerio

Alignment Length:	881	Identity:	312/881 - (35%)
Similarity:	471/881 - (53%)	Gaps:	101/881 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 FVILWSLFSIHISVNWAQYENFGGYDNYQSLESVPIGLLTDQNTEQMNIVFDHAIDVANQE---- 66
            |::|..:..:.:|..  |....||.  :::||:.||.:        ..:.|..|:...|:.
Zfish    47 FILLCLMAEVGLSAQ--QVLRIGGI--FETLENEPISV--------EELAFKFAVTNINRNRTLM 99

  Fly    67 VGTSLTSLKEEVNYGDAYQSYGKLCRMLETGIAGVFGPSSRHTAVHLMSICDAMDIPHIYSYMS- 130
            ..|:||...:.:|..|::::..:.|..|..|:|.|||||...:...:.|||:|:::|||.:...
Zfish   100 PNTTLTYDIQRINLFDSFEASRRACDQLALGVAAVFGPSHSSSVSAVQSICNALEVPHIQTRWKH 164

  Fly   131 ---ENAEGF--NLHPHPADLAKALYSLITEFNWTRFIFLYESAEYLNILNELTTMLGKSGTVITV 190
               :|.:.|  ||:|..|.:::|:..::..:.|.....:||.|..|..|.||         :...
Zfish   165 PSVDNKDSFYINLYPDYASISRAVLDIVQFYKWKAVTVVYEDATGLIRLQEL---------IKAP 220

  Fly   191 LRYDMQL--------NGNYKQVLRRVRKSVDNRIVVVGSSETMPEFLNQAQQVGIINEDYKYIIG 247
            .||.:::        :.:.:.:|:.::|..:..::...|.:|..:.|.|...:|::.|.|.:...
Zfish   221 SRYSIKIKIRQLPTGSKDARPLLKEMKKGKEFCVIFDCSYQTAADVLKQLLSMGMMTEYYHFFFT 285

  Fly   248 NLDFHSFDLEEYKYSEANITGLRLFSPEKMAVKELLMKLGY------PTDQDEFRNGSCPITVEM 306
            .||.:|.|||.::||..|:||.||.:.:...|..::.|...      |..:...::|.  :|.|.
Zfish   286 TLDLYSLDLEPFRYSGVNMTGFRLLNIDNPQVASVVEKWSMERLQAPPKPETGLQDGM--MTTEA 348

  Fly   307 ALTYDAVQLFAQTLKNLPFKPMPQNCSQRTESVRD--------DGSSFKNYMRTLRLTDRLLTGP 363
            ||.||||.:.|..         .|..||.|.|...        .||.|.:..:..:...  |||.
Zfish   349 ALMYDAVYMVAAA---------SQRASQITVSSLQCHRHKPWRFGSRFISMFKEAQWNG--LTGQ 402

  Fly   364 IYFE--GNVRKGYHLDVIELQPSGI-------------VKVGTWDEDRQYRPQRLAPTTAQFD-- 411
            |...  ..:||.:.||:|.|:..|:             .|:|.|:.:     ..|..|.:..|
Zfish   403 IIINKTDGLRKDFDLDIISLKEDGLEKPLESGRFNKVWKKIGVWNSN-----TGLNLTDSNKDKN 462

  Fly   412 -SVDNSLANKTFIILLSVPNKPYAQLVETYKQLEGNSQYEGYGVDLIKELADKLGFNF--TFVNG 473
             :|.:|:||:|.|:...:.| ||....::.|.|.||.::|||.:||:|||::.|||::  ..|..
Zfish   463 TNVTDSMANRTLIVTTILEN-PYVMYKKSDKPLYGNDRFEGYCLDLLKELSNILGFSYEVKLVTD 526

  Fly   474 GNDYGSYNKSTNESTGMLREIMTGRADLAITDLTITSEREQALDFTIPFMNLGIAILYLKPQKAT 538
            |. ||:.| ...|..||:||::...||||:..||||..||:.:||:.|||.|||:|||.||....
Zfish   527 GK-YGAQN-DKGEWNGMVRELIDHVADLAVAPLTITYVREKVIDFSKPFMTLGISILYHKPNGTN 589

  Fly   539 PELFTFMDPFSEEVWWFLGFSFLGVSLSFFILGRLSPSEWDNPYPCIEEPEELENQFTLGNSIWF 603
            |.:|:|::|.|.::|.::..:.||||...|::.|.:|.||.||:||..:.:.:||.|||.||:||
Zfish   590 PGVFSFLNPLSPDIWMYVLLACLGVSCVLFVIARFTPYEWYNPHPCNPDSDVVENNFTLINSVWF 654

  Fly   604 TTGALLQQGSEIGPKALSTRTVASFWWFFTLIVVSSYTANLAAFLTIEKPQSLINSVDDLADNKD 668
            ..|||:|||||:.|||||||.|...|||||||::||||||||||||:|:..|.|:|.|||| .:.
Zfish   655 GVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMDSPIDSADDLA-KQT 718

  Fly   669 GVVYGAKKTGSTRNFFMTSAEERYKKMNKFMSENPQ-YLTEDNMEGVNRVKTNTHYAFLMESTSI 732
            .:.|||.:.|||..||..|....|:||..|||.... .|.::|.||:.||.| |.||.|||||||
Zfish   719 KIEYGAVRDGSTMTFFKKSKISTYEKMWAFMSSRKNTALVKNNREGIQRVLT-TDYALLMESTSI 782

  Fly   733 EYNTKRECNLKKIGDALDEKGYGIAMRKDWPHRGKFNNALLELQEQGVLEKMKNKWWNEVGTGIC 797
            ||.::|.|||.:||..:|.||||:......|:|.|...|:|:|||:|.|..||.|||.  |.|
Zfish   783 EYISQRNCNLTQIGGLIDSKGYGVGTPIGSPYRDKVTIAILQLQEEGKLHMMKEKWWR--GNG-- 843

  Fly   798 ATKEDAPDATPLDMNNLEGVFFVLLVGSCCALLYGI 833
            ..:||:.:|:.|.:.|:.|:|.||..|...::...|
Zfish   844 CPEEDSKEASALGVENIGGIFIVLAAGLVLSVFVAI 879

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIE	NP_001036733.1	PBP1_iGluR_Kainate	42..396	CDD:107377	98/400 (25%)
		ANF_receptor	51..382	CDD:279440	93/364 (26%)
		PBP2_iGluR_Kainate	419..790	CDD:270432	184/373 (49%)
		Lig_chan	551..824	CDD:278489	137/273 (50%)
grik1b	XP_690040.5	Periplasmic_Binding_Protein_Type_1	62..455	CDD:299141	106/429 (25%)
		ANF_receptor	80..423	CDD:279440	93/372 (25%)
		Periplasmic_Binding_Protein_Type_2	471..840	CDD:304360	184/373 (49%)
		Lig_chan	602..871	CDD:278489	137/274 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591291
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	1	1.010	-	-		D60688at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.760