Protein Alignment GluRIIE and grin2bb

DIOPT Version :10

• Sequence 1: NP_001036733.1
• Gene: GluRIIE / 318623
• FlyBaseID: FBgn0051201
• Length: 897
• Species: Drosophila melanogaster
• Sequence 2: NP_001121809.1
• Gene: grin2bb / 559976
• ZFINID: ZDB-GENE-061207-27
• Length: 1770
• Species: Danio rerio
• Alignment Length: 984
• Identity: 224/984 - (22%)
• Similarity: 402/984 - (40%)
• Gaps: 207/984 - (21%)

  Fly    28 GGYDNYQSLES---------VPIGLLTDQNTEQMNIVFDHAIDVANQEVG-TSLTSLKE------ 76
            ||. |.||:.|         .|:|       ..|:..|...:.:|...|| :|..||.|
Zfish    76 GGM-NSQSIISPPHYPPPGVSPVG-------PPMSPKFAQGLSIAVILVGNSSEVSLSEGLEKED 132

  Fly    77 -------------EVNYGDAYQSYGKLCRMLE----TGIAGVFGPSSRHTAV-HLMSICDAM-DI 122
                         .:|..|......::|.::.    .|:  |||..:...|: .::....|. .|
Zfish   133 FLHVPLPPKVELVTMNETDPKSIINRICALMSRNWLQGV--VFGDDTDQEAIAQILDFISAQTHI 195

  Fly   123 P---------HIYSYMSENAEGFNLHPHPADLAKALYSLITEFNWTRFIFLYESAEY---LNILN 175
            |         .|.:...:::..|...|.....|..:.:::.|::|  :||...:..|   .:.:|
Zfish   196 PILGIRGGSSMIMAAKDDHSMFFQFGPSIEQQASVMLNIMEEYDW--YIFSIVTTYYPGHQDFVN 258

  Fly   176 ELTTMLGKS---GTVITVLRYDMQLNGNYKQVLRRVRKSVDNRIVVVGSSETMPEFLNQAQQVGI 237
            .:.:.:..|   ..:..||..||.::....::..:::|.....|::..:.|........|..||:
Zfish   259 RIRSTVDNSFVGWELEEVLLLDMSVDDGDSKIQNQMKKLQSPVILLYCTKEEATTIFEVAHSVGL 323

  Fly   238 INEDYKYIIGNLDFHSFDLEEYKYSEANI--TGLRLFSPEKMAVKELLMKLGYPTDQDEFRNGSC 300
            ....|.:|:.:|.....|      :..|:  ||              |:.:.|    ||:..|
Zfish   324 TGYGYTWIVPSLVAGDTD------NVPNVFPTG--------------LISVSY----DEWDYG-- 362

  Fly   301 PITVEMALTYDAVQLFAQTLKNL-----PFKPMPQNCSQRTESVRDDGSSFKNYMRTLRLTDRLL 360
               :| |...|||.:.|.....:     |...:...|....:.   .||...|....||.   |:
Zfish   363 ---LE-ARVRDAVAIIAMATSTMMLDRGPHTLLKSGCHGAPDK---KGSKSGNPNEVLRY---LM 417

  Fly   361 TGPIYFEGNVRKGYHLDVIELQPSGIV----------KVGTWDEDRQYRPQRLAPTTAQFDSVDN 415
            .  :.|||. ...:..|..::.|..::          :||.|:.........:.|....:...:.
Zfish   418 N--VTFEGR-NLSFSEDGFQMHPKLVIILLNKERQYERVGKWENGSLAMKYHVWPRFELYSDAEE 479

  Fly   416 ---------SLANKTFIIL-----LS-------VPNKPYAQLVETYKQLEGNSQY------EGYG 453
                     :|....|:|:     ||       ||.:...:|    :.|.|:|..      :|:.
Zfish   480 REDDHLSIVTLEEAPFVIVEDVDPLSGTCMRNTVPCRKQLKL----QNLTGDSGIYIKRCCKGFC 540

  Fly   454 VDLIKELADKLGFNFTFVNGGNDYGSYNKSTNES-TGMLREIMTGRADLAITDLTITSEREQALD 517
            :|::|::|..:.|.:......|  |.:.|..|.: .||:.|::...|.:|:..|||..||.:.:|
Zfish   541 IDILKKIAKSVKFTYDLYLVTN--GKHGKKINGTWNGMVGEVVLKNAHMAVGSLTINEERSEVID 603

  Fly   518 FTIPFMNLGIAILYLKPQKATPELFTFMDPFSEEVWWFLGFSFLGVS-LSFFILGRLSPSEWDNP 581
            |::||:..||::: :.....|.....|::|||.:||..:....|.|| ::.|:....||..::.
Zfish   604 FSVPFIETGISVM-VSRSNGTVSPSAFLEPFSADVWVMMFVMLLIVSAVAVFVFEYFSPVGYNR- 666

  Fly   582 YPCIEEPEELEN-QFTLGNSIWFTTGALLQQGSEI-GPKALSTRTVASFWWFFTLIVVSSYTANL 644
              |:.:..|... .||:|.:||...|.:......: .||..:::.:.|.|.||.:|.::||||||
Zfish   667 --CLADGREPGGPSFTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANL 729

  Fly   645 AAFLTIEKPQSLINSVDDLADNK--------DGVVYGAKKTGST-RNFFMTSAEERYKKMNKFMS 700
            |||:..|:   .::.|..|:|.|        ....:|....||| ||.     ...||:|:.:|:
Zfish   730 AAFMIQEE---YVDQVTGLSDKKFQHPNDFSPPFRFGTVPNGSTERNI-----RNNYKEMHSYMT 786

  Fly   701 ENPQYLTEDNMEGVNRVKTNTHYAFLMESTSIEYNTKRE--CNLKKIGDA--LDEKGYGIAMRKD 761
            ...|   ::..|.::.:|:....||:.::..:.|...|:  |.|..||..  ....|||||::||
Zfish   787 SFHQ---KNVNEALHSLKSGKLDAFIYDAAVLNYMAGRDEGCKLVTIGSGYIFATTGYGIAIQKD 848

  Fly   762 WPHRGKFNNALLELQEQGVLEKMKNKWWNEVGTGICATKEDAPDATPLDMNNLEGVFFVLLVGSC 826
            ...:...:.|:|:|...|.:|:::..|.    ||||..:::...::.||::|:.|||::|  |:.
Zfish   849 SGWKRAVDLAILQLFGDGEMEELEALWL----TGICHNEKNEVMSSQLDVDNMAGVFYML--GAA 907

  Fly   827 CALLYGIISWVLFVMKKAHHYRVPLRDAL------KEEFQFVIDFNNY-----VRVLKNSASIYS 880
            .||     |.:.|:.:  |.:...||...      |....|.|....|     |::.:|.:::.|
Zfish   908 MAL-----SLITFIAE--HLFYWQLRFCFMGVCSGKPGMTFSISRGIYSCIHGVQIEENKSALNS 965

  Fly   881 RSRQSSMSV 889
            .|....|::
Zfish   966 PSATMKMNM 974

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIE	NP_001036733.1	PBP1_iGluR_Kainate	40..402	CDD:380605	77/419 (18%)
		PBP2_iGluR_Kainate	419..790	CDD:270432	111/405 (27%)
		Lig_chan	551..824	CDD:459656	82/288 (28%)
grin2bb	NP_001121809.1	PBP1_iGluR_NMDA_NR2	107..465	CDD:380601	73/400 (18%)
		PBP2_iGluR_NMDA_Nr2	482..882	CDD:270436	116/424 (27%)
		NMDAR2_C	919..1770	CDD:463148	12/56 (21%)