Protein Alignment GluRIIE and grik4

DIOPT Version :10

• Sequence 1: NP_001036733.1
• Gene: GluRIIE / 318623
• FlyBaseID: FBgn0051201
• Length: 897
• Species: Drosophila melanogaster
• Sequence 2: XP_021322088.1
• Gene: grik4 / 556582
• ZFINID: ZDB-GENE-070821-5
• Length: 965
• Species: Danio rerio
• Alignment Length: 840
• Identity: 278/840 - (33%)
• Similarity: 439/840 - (52%)
• Gaps: 69/840 - (8%)

  Fly    59 AIDVANQEVGTSLTSLKE----EVNYGDAYQSYGKLCRMLETGIAGVFGPSSRHTAVHLMS-ICD 118
            |.|..|:....|.|...|    |:.....|::...:|:::..|:..|.|||:...:..::| ||.
Zfish    48 AKDSINRSSNRSTTGKLEVDIFELLRDSEYETGETMCQIMSKGVVAVLGPSASPASNSIISNICG 112

  Fly   119 AMDIPH-------IYSYMSENAEGFNLHPHPADLAKALYSLITEFNWTRFIFLYESAEYLNILNE 176
            ..::|:       |...........:|.|...|::.|:..|:|.||.:....:...|:.|..|..
Zfish   113 EKEVPYVKVAPEDILKVQFPRFTTLDLRPTNTDISMAVAGLLTFFNSSTSCLICAQADCLLNLEV 177

  Fly   177 LTTMLGKSGTVITVLRYDMQLNGNYKQVLRRVRKSVDNRIVVVGSSETMPEFLNQAQQVGIINED 241
            |......|...::|...|...:..  .:|:.:|......|:|..::......|.:|.::|:::..
Zfish   178 LLRQFLISKETLSVRMLDDSQDPT--PLLKEIRDDKTATIIVDANATMSHVILERASELGMLSVY 240

  Fly   242 YKYIIGNLDFHSFDLEEYKYSEANITGLRLFSPEKMAVKELLMKL--GYPTDQDEFRNGSCPITV 304
            |.||:.:|:|....|::......||.|..:|:......::.::.|  .:..:.|.......|::
Zfish   241 YTYILTSLEFSLLRLDDLADQRVNIVGFSVFNRTHPFFQDFVLSLNRSWQENCDHAPFAGTPLS- 304

  Fly   305 EMALTYDAVQLFAQTLKNLPFKPMPQNCSQ---------RTESVRDDGSSFKNYMRTLRLTDRLL 360
             .||.:|||......::.|       |.||         ::..:.:.|:|..||:|.:.|..  |
Zfish   305 -SALLFDAVHTVVAAVQEL-------NRSQNVGATQLSCKSSKIWEHGTSLMNYLRMVELEG--L 359

  Fly   361 TGPIYFEG-NVRKGYHLDVIELQPSGIVKVGTWDEDRQYRPQRLAPTTAQFDSVDNSLANKTFII 424
            ||.|.|.. ..|..|.|.:::....|:.::|.|..::....:|..|:.    :|.::|.|.|..|
Zfish   360 TGHIEFNSKGQRSNYALRIMQNSRDGLRQIGQWHSEQGLSMERKLPSL----NVTDTLFNTTLTI 420

  Fly   425 LLSVPNKPYAQLVETYKQLEGNSQYEGYGVDLIKELADKLGFNFTF---------VNGGNDYGSY 480
            ...:.| ||..|...:::||||.:|||:.||::|||||.|.|.:..         |.|.|  |::
Zfish   421 TTILEN-PYVMLRANHQELEGNDRYEGFCVDMLKELADILKFKYRIRLVGDGVYGVPGAN--GTW 482

  Fly   481 NKSTNESTGMLREIMTGRADLAITDLTITSEREQALDFTIPFMNLGIAILYLKPQKATPELFTFM 545
                   |||:.|:::.:||||:..||||:|||:.:||:.|||.|||:|:|.......|..|:|:
Zfish   483 -------TGMVGELISRKADLAVAALTITAEREKVIDFSKPFMTLGISIMYRVHIGRRPGYFSFL 540

  Fly   546 DPFSEEVWWFLGFSFLGVSLSFFILGRLSPSEWDNPYPCIE-EPEELENQFTLGNSIWFTTGALL 609
            ||||..||.|:..::|.||...|::.||:|.||.||:||:: ....|.||::||||.||..|..:
Zfish   541 DPFSPGVWLFMLLAYLAVSCVLFLVARLTPYEWYNPHPCLKGRCSLLINQYSLGNSFWFPVGGFM 605

  Fly   610 QQGSEIGPKALSTRTVASFWWFFTLIVVSSYTANLAAFLTIEKPQSLINSVDDLADNKDGVVYGA 674
            ||||.|.|:|||||.|:..||.||||::||||||||||||:::.:..|.||||||| :..:.||.
Zfish   606 QQGSTIAPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMEVPIESVDDLAD-QTAIEYGT 669

  Fly   675 KKTGSTRNFFMTSAEERYKKMNKFM-SENPQYLTEDNMEGVNRVKTNTHYAFLMESTSIEYNTKR 738
            ...|||..||..|..:.|::|..|| |:.|....:...||:.|| .|::||:|:|||..||..:|
Zfish   670 MHGGSTMTFFQNSRYQTYQRMWNFMYSKQPSVFVKSTEEGIARV-LNSNYAYLLESTMNEYYRQR 733

  Fly   739 ECNLKKIGDALDEKGYGIAMRKDWPHRGKFNNALLELQEQGVLEKMKNKWWNEVGTGICATKEDA 803
            .|||.:||..||.|||||.|.....:|.:|:.|:|.|||:..||.:|.|||:   .|.|..:||
Zfish   734 NCNLTQIGGLLDTKGYGIGMPLGSVYRDEFDLAILRLQEENRLEILKRKWWD---GGKCPKEED- 794

  Fly   804 PDATPLDMNNLEGVFFVLLVGSCCALLYGIISWVLFVMKKAHHYRVPLRDALKEEFQFVI 863
            ..|..|.|.|:.|:|.||:.|...|:...::.:| ::::......:.:.:.:..|.|.::
Zfish   795 HRAKGLGMENIGGIFVVLVCGLLVAIFMAVLEFV-WMLRHTPGTELSVCEEMLRELQGIV 853

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIE	NP_001036733.1	PBP1_iGluR_Kainate	40..402	CDD:380605	80/366 (22%)
		PBP2_iGluR_Kainate	419..790	CDD:270432	176/381 (46%)
		Lig_chan	551..824	CDD:459656	130/274 (47%)
grik4	XP_021322088.1	Periplasmic_Binding_Protein_type1	24..401	CDD:471960	80/365 (22%)
		PBP2_iGluR_kainate_KA1	425..785	CDD:270442	173/371 (47%)