DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIE and grik2

DIOPT Version :9

Sequence 1:	NP_001036733.1	Gene:	GluRIIE / 318623	FlyBaseID:	FBgn0051201	Length:	897	Species:	Drosophila melanogaster
Sequence 2:	XP_021322472.1	Gene:	grik2 / 556013	ZFINID:	ZDB-GENE-080414-1	Length:	908	Species:	Danio rerio

Alignment Length:	837	Identity:	308/837 - (36%)
Similarity:	464/837 - (55%)	Gaps:	83/837 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 FGGYDNYQSLESVPIGLLTDQNTEQMNIVFDHAIDVANQE----VGTSLTSLKEEVNYGDAYQSY 87
            |||.  ::|:||.|.|      .|:  :.|..|::..|:.    ..|:||...:.:|..|::::.
Zfish    38 FGGI--FESIESGPSG------AEE--LAFKFALNTINRNRTLLPNTTLTYDIQRINIHDSFEAS 92

  Fly    88 GKLCRMLETGIAGVFGPSSRHTAVHLMSICDAMDIPHIYS----YMSENAEGF--NLHPHPADLA 146
            .|.|..|..|:|.:||||...:|..:.|||:|:.:|||.:    .:|:|.:.|  ||:|..:.|:
Zfish    93 RKACDQLSLGVAAIFGPSHSSSANAVQSICNALGVPHIQTKWKHQVSDNRDSFYVNLYPDFSSLS 157

  Fly   147 KALYSLITEFNWTRFIFLYESAEYLNILNELTTMLGKSGTVITVLRYDMQL--------NGNYKQ 203
            :|:..|:..|.|.....:|:.:..|..|.||         :....||:::|        ..:.|.
Zfish   158 RAILDLVHFFKWKTVTVVYDDSTGLIRLQEL---------IKAPSRYNIRLKIRQLPADTKDAKP 213

  Fly   204 VLRRVRKSVDNRIVVVGSSETMPEFLNQAQQVGIINEDYKYIIGNLDFHSFDLEEYKYSEANITG 268
            :|:.:::..:..::.....|.....|.||..:|::.|.|.||...||..:.|:|.|:||..|:||
Zfish   214 LLKEMKRGKEFHVIFDCGHEMAAGILKQALAMGMMTEYYHYIFTTLDLFALDVEPYRYSGVNMTG 278

  Fly   269 LRLFSPEKMAVKELLMK-----LGYPTDQDE-FRNGSCPITVEMALTYDAVQLFAQTLKNLPFKP 327
            .|:.:.|...|..::.|     |..|...|. ..:|.  :|.:.||.||||.:.|..::.
Zfish   279 FRILNTENSQVSSIIEKWSMERLQAPPKPDSGLLDGF--MTTDAALMYDAVHVVAVAVQQ----- 336

  Fly   328 MPQNCSQRTESVRDDGSSFKNYMRTLRLTDRL--LTGPIYFE--GNVRKGYHLDVIELQPSGIVK 388
            .||......:..|.....|.|...||......  |||.|.|.  ..:|..:.||||.|:..|:.|
Zfish   337 SPQITVSSLQCNRHKPWRFGNRFMTLIKEAHWDGLTGRINFNRTNGLRTDFDLDVISLKEEGLEK 401

  Fly   389 VGTWD--------EDRQYRPQRLAPTTAQFDSVDNSLANKTFIILLSVPNKPYAQLVETYKQLEG 445
            :||||        |:::.:       ||   :|.:||:|:: :::.::..:||....::.|.|.|
Zfish   402 IGTWDPASGLNMTENQKGK-------TA---NVTDSLSNRS-LVVSTILEEPYVMFKKSDKPLYG 455

  Fly   446 NSQYEGYGVDLIKELADKLGFNF--TFVNGGNDYGSYNKSTNESTGMLREIMTGRADLAITDLTI 508
            |.::|||.|||::|||..|||.:  ..|..|. ||:.::|:.:..||:||:|..:||||:..|.|
Zfish   456 NDRFEGYCVDLLRELAAILGFGYELRLVEDGR-YGAQDESSGQWNGMVRELMDHKADLAVAPLAI 519

  Fly   509 TSEREQALDFTIPFMNLGIAILYLKPQKATPELFTFMDPFSEEVWWFLGFSFLGVSLSFFILGRL 573
            |..||:.:||:.|||.|||:|||.||....|.:|:|::|.|.::|.::..::||||...|::.|.
Zfish   520 TYVREKVIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARF 584

  Fly   574 SPSEWDNPYPCIEEPEELENQFTLGNSIWFTTGALLQQGSEIGPKALSTRTVASFWWFFTLIVVS 638
            ||.||.||:||..:.:.:||.|||.||.||..|||:|||||:.|||||||.|...|||||||::|
Zfish   585 SPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIIS 649

  Fly   639 SYTANLAAFLTIEKPQSLINSVDDLADNKDGVVYGAKKTGSTRNFFMTSAEERYKKMNKFM-SEN 702
            |||||||||||:|:.:|.|:|.|||| .:..:.||..:.|||..||..:....|.||.:|| |..
Zfish   650 SYTANLAAFLTVERMESPIDSADDLA-KQTKIEYGVVEDGSTMTFFKKTKISTYDKMWEFMSSRR 713

  Fly   703 PQYLTEDNMEGVNRVKTNTHYAFLMESTSIEYNTKRECNLKKIGDALDEKGYGIAMRKDWPHRGK 767
            ...:.:...||:.||.| :.||||||||:||:.|:|.|||.:||..:|.|.||:......|:|.|
Zfish   714 HSVMVKSIEEGIERVLT-SDYAFLMESTTIEFVTQRNCNLTQIGGLIDSKAYGVGTPMGSPYRDK 777

  Fly   768 FNNALLELQEQGVLEKMKNKWWNEVGTGICATKEDAPDATPLDMNNLEGVFFVLLVG 824
            ...|:|:|||:|.|..||.|||.  |.|  ..:|:..:|:.|.:.|:.|:|.||..|
Zfish   778 ITIAILQLQEEGKLHMMKEKWWR--GNG--CPEEENKEASALGVQNIGGIFIVLAAG 830

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIE	NP_001036733.1	PBP1_iGluR_Kainate	42..396	CDD:107377	108/389 (28%)
		ANF_receptor	51..382	CDD:279440	98/358 (27%)
		PBP2_iGluR_Kainate	419..790	CDD:270432	176/373 (47%)
		Lig_chan	551..824	CDD:278489	131/273 (48%)
grik2	XP_021322472.1	PBP1_iGluR_Kainate	37..414	CDD:380605	114/401 (28%)
grik2	XP_021322472.1	Periplasmic_Binding_Protein_Type_2	430..800	CDD:419667	176/373 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591325
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	1	1.010	-	-		D60688at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.760