Protein Alignment GluRIIE and Gria3

DIOPT Version :10

• Sequence 1: NP_001036733.1
• Gene: GluRIIE / 318623
• FlyBaseID: FBgn0051201
• Length: 897
• Species: Drosophila melanogaster
• Sequence 2: NP_058582.4
• Gene: Gria3 / 53623
• MGIID: 95810
• Length: 888
• Species: Mus musculus
• Alignment Length: 874
• Identity: 293/874 - (33%)
• Similarity: 459/874 - (52%)
• Gaps: 87/874 - (9%)

  Fly     6 FVILWSLFSIHISVNWAQYENFGGYDNYQSLESVPIGLLTDQNTEQMNIVFDHAIDV--ANQEVG 68
            |::|..|...|           ||:.|     ::.||.|..:||.|.:..|..|:.:  .||...
Mouse    11 FLVLGLLGHSH-----------GGFPN-----TISIGGLFMRNTVQEHSAFRFAVQLYNTNQNTT 59

  Fly    69 TSLTSLKEEVNYGDAYQSY---GKLCRMLETGIAGVFGPSSRHTAVHLMSICDAMDIPHIY-SYM 129
            .....|...|::.|:..|:   ...|.....|:..:||...:.:...|.|.|.|:....:. |:.
Mouse    60 EKPFHLNYHVDHLDSSNSFSVTNAFCSQFSRGVYAIFGFYDQMSMNTLTSFCGALHTSFVTPSFP 124

  Fly   130 SENAEGFNLHPHPADLAKALYSLITEFNWTRFIFLYESAEYLNILNELTTMLGKSGTVITVLRYD 194
            ::....|.:...|| |..|:.||:..:.|.:|::||::....:||..:.....::...:|.
Mouse   125 TDADVQFVIQMRPA-LKGAILSLLGYYKWEKFVYLYDTERGFSILQAIMEAAVQNNWQVTA---- 184

  Fly   195 MQLNGNYK--QVLRRVRKSVD----NRIVVVGSSETMPEFLNQAQQVGIINEDYKYIIGNLDFHS 253
             :..||.|  |..||:.:.:|    .|.::....|.:...|.|...:|..:..|.|::.||.|..
Mouse   185 -RSVGNIKDIQEFRRIIEEMDRRQEKRYLIDCEVERINTILEQVVILGKHSRGYHYMLANLGFTD 248

  Fly   254 FDLEEYKYSEANITGLRLFSPEKMAVKELLMKLGYPTDQDEFRNG-SCPITVEMALTYDAVQLFA 317
            ..||...:..|||||.::.:.|...|::.:.: ....|:.||... :.|:....|||:||:.:.|
Mouse   249 IVLERVMHGGANITGFQIVNNENPMVQQFIQR-WVRLDEREFPEAKNAPLKYTSALTHDAILVIA 312

  Fly   318 QTLKNLPFKPMPQNCSQRTESVR--DDGSSFKN----------YMRTLRLTD-RLLTGPIYFEGN 369
            :..:.|.        .||.:..|  ..|....|          ..|.|::.. :.:||.|.|:..
Mouse   313 EAFRYLR--------RQRVDVSRRGSAGDCLANPAVPWSQGIDIERALKMVQVQGMTGNIQFDTY 369

  Fly   370 VRK-GYHLDVIELQPSGIVKVGTWDEDRQYRPQRLAPTTAQFDSVDNSLANKTFIILLSVPNKPY 433
            .|: .|.:||.|::.||..|.|.|:|   |  :|..|.:.|..|.|:|.:....|::.::...||
Mouse   370 GRRTNYTIDVYEMKVSGSRKAGYWNE---Y--ERFVPFSDQQISNDSSSSENRTIVVTTILESPY 429

  Fly   434 AQLVETYKQLEGNSQYEGYGVDLIKELAD--KLGFNFTFVNGGNDYGSYNKSTNESTGMLREIMT 496
            ....:.::|||||.:||||.|||..|:|.  ::.:..:.|..|. ||:.:..|....||:.|::.
Mouse   430 VMYKKNHEQLEGNERYEGYCVDLAYEIAKHVRIKYKLSIVGDGK-YGARDPETKIWNGMVGELVY 493

  Fly   497 GRADLAITDLTITSEREQALDFTIPFMNLGIAILYLKPQKATPELFTFMDPFSEEVWWFLGFSFL 561
            ||||:|:..||||..||:.:||:.|||:|||:|:..||||:.|.:|:|:||.:.|:|..:.|:::
Mouse   494 GRADIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYI 558

  Fly   562 GVSLSFFILGRLSPSEW---DNPYPCIEEPEELE------NQFTLGNSIWFTTGALLQQGSEIGP 617
            |||:..|::.|.||.||   ||.    |||.:.:      |:|.:.||:||:.||.:|||.:|.|
Mouse   559 GVSVVLFLVSRFSPYEWHLEDNN----EEPRDPQSPPDPPNEFGIFNSLWFSLGAFMQQGCDISP 619

  Fly   618 KALSTRTVASFWWFFTLIVVSSYTANLAAFLTIEKPQSLINSVDDLADNKDGVVYGAKKTGSTRN 682
            ::||.|.|...|||||||::||||||||||||:|:..|.|.|.:|||...: :.||...:|||:.
Mouse   620 RSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTE-IAYGTLDSGSTKE 683

  Fly   683 FFMTSAEERYKKMNKFM-SENPQYLTEDNMEGVNRV-KTNTHYAFLMESTSIEYNTKRE-CNLKK 744
            ||..|....|:||..:| |..|...|:...:||.|| |:...:|||:|||..||..:|: |:..|
Mouse   684 FFRRSKIAVYEKMWSYMKSAEPSVFTKTTADGVARVRKSKGKFAFLLESTMNEYIEQRKPCDTMK 748

  Fly   745 IGDALDEKGYGIAMRKDWPHRGKFNNALLELQEQGVLEKMKNKWWNEVGTGICATKED-APDAT- 807
            :|..||.||||:|..|....|...|.|:|:|.|||:|:|:|||||.:.|.  |..|:. :.|.|
Mouse   749 VGGNLDSKGYGVATPKGSALRTPVNLAVLKLSEQGILDKLKNKWWYDKGE--CGAKDSGSKDKTS 811

  Fly   808 PLDMNNLEGVFFVLLVGSCCALLYGIISW 836
            .|.::|:.|||::|:.|...|::..:|.:
Mouse   812 ALSLSNVAGVFYILVGGLGLAMMVALIEF 840

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIE	NP_001036733.1	PBP1_iGluR_Kainate	40..402	CDD:380605	97/388 (25%)
		PBP2_iGluR_Kainate	419..790	CDD:270432	168/384 (44%)
		Lig_chan	551..824	CDD:459656	126/286 (44%)
Gria3	NP_058582.4	PBP1_iGluR_AMPA_GluR3	29..403	CDD:380610	99/393 (25%)
		PBP2_iGluR_AMPA	416..799	CDD:270433	170/390 (44%)