DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GluRIIE and grin2da

DIOPT Version :9

Sequence 1:	NP_001036733.1	Gene:	GluRIIE / 318623	FlyBaseID:	FBgn0051201	Length:	897	Species:	Drosophila melanogaster
Sequence 2:	XP_009292354.1	Gene:	grin2da / 449864	ZFINID:	ZDB-GENE-041008-124	Length:	1916	Species:	Danio rerio

Alignment Length:	788	Identity:	188/788 - (23%)
Similarity:	318/788 - (40%)	Gaps:	183/788 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   147 KALYSLITEFNWTRFIFLYESAEYLNILNELTTMLGKSGTVITVLRYDMQLNGNYKQVLRRVRKS 211
            :.::.::.||:||.|                        :|:|...:      .|:..|..|...
Zfish   204 EVIFEVLEEFDWTAF------------------------SVVTTRHH------GYEDFLAMVEGM 238

  Fly   212 VDNRIVVVGSSETMPEFLNQAQQVG------IINEDYKYIIGNLDFHSFDLEEYKYSEANITGLR 270
            :|...  :|........||.....|      ::.|:...:  .|.:.|.:..|..:..|..:|..
Zfish   239 IDGSF--IGWERKSVVMLNLTDDPGGARTRRLLKENEAQV--RLLYCSQEEAEQIFKAAWASGQA 299

  Fly   271 LFSPEKMAVKELLMKLGY-----------PTD-QDEFRNGSCP-ITVEMALTYDAVQLFAQTLKN 322
            ..|....||...|..||.           |.. :||.|..... ::|   ||:.|:.|
Zfish   300 TPSHMWFAVGPGLSGLGLEGLPKALFAVRPQGWRDEPRRRIAKGVSV---LTHGAMAL------- 354

  Fly   323 LPFKPMPQNCSQRTESVRDDGSSFK-NYMRTLRLTDRLLTGPIYFEGNV----------RKGY-- 374
                        |.|.....|:||. |.|.....|.| :.|.|.|..|:          ..||
Zfish   355 ------------RREYGGARGTSFAGNCMMDGNQTQR-VPGRIRFFSNITLSGRDYSFNNDGYLA 406

  Fly   375 --HLDVIELQPS-GIVKVGTWDED---RQYRP-QRLAPTTAQFDSVDN----SLANKTFIILL-- 426
              .||||..... |..:||.|:..   .:|.| .|..|.....|...:    :|..:.|:|:.
Zfish   407 NPLLDVISYTAGRGWEEVGWWENGVLRLRYPPWSRYGPFLKPLDDSQHLRVVTLEERPFVIVEPA 471

  Fly   427 ----------SVP------NKPYAQLVETYKQLEGNSQYEGYGVDLIKELADKLGFNFTFV---- 471
                      |||      |....:.:::.|..     .:|:.:|::|.||..:||.:...
Zfish   472 DPGTGSCIRDSVPCRLPLNNSMVVEGIQSMKHC-----CKGFCIDVLKRLAKIVGFTYDLYLVTN 531

  Fly   472 --NGGNDYGSYNKSTNESTGMLREIMTGRADLAITDLTITSEREQALDFTIPFMNLGIAILYLKP 534
              :|.|..|.:|       ||:.|:::.|||:||..|||..||.:.::|::||:..||::: :..
Zfish   532 GRHGKNIDGQWN-------GMVGEVVSKRADMAIGSLTINEERSEVVEFSVPFVETGISVM-VSR 588

  Fly   535 QKATPELFTFMDPFSEEVWWFLGFSFLG-VSLSFFILGRLSPSEWDNPYPCIEEPEELE------ 592
            ...|.....|::|:|..||..:....|. |:::.||....||..::         ..|:
Zfish   589 SNGTVSPSAFLEPYSPAVWVMMFVMCLSVVAVTVFIFEFFSPVGYN---------RSLQSGKTAG 644

  Fly   593 -NQFTLGNSIWFTTGALLQQGSEI-GPKALSTRTVASFWWFFTLIVVSSYTANLAAFLTIEKPQS 655
             ::||:|.|||.....:......: .|:..:::.:...|.||.:|.::|||||||||:..|:
Zfish   645 GSKFTIGKSIWLLWALVFNNSVPVENPRGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEE--- 706

  Fly   656 LINSVDDLADNK--------DGVVYGAKKTGSTRNFFMTSAEERYKKMNKFMSENPQYLTEDNME 712
            .|::|..|:|.|        ..:.:|....|||..    :....|..|:::|..|.|...||.:|
Zfish   707 YIDTVSGLSDKKFQHPTEQYPPLRFGTVPNGSTEE----NIRSNYPNMHQYMVRNNQRGVEDAIE 767

  Fly   713 GVNRVKTNTHYAFLMESTSIEYNTKRE--CNLKKIGD--ALDEKGYGIAMRKDWPHRGKFNNALL 773
               .:||....||:.::..:.|..:::  |.:..||.  .....|||:|:.|:...:...:.|||
Zfish   768 ---NLKTGKLDAFIYDAAVLNYMARKDEGCKVMTIGSGKVFATTGYGVALHKNSRWKRPLDLALL 829

  Fly   774 ELQEQGVLEKMKNKWWNEVGTGICATKEDAPDATPLDMNNLEGVFFVLLVGSCCALLYGIISWVL 838
            :|.....::.::..|.    :|||...:....::.||::|:.|||::|||....:||  :.:|..
Zfish   830 QLVGDDEIDMLERLWL----SGICHNDKIEVMSSKLDIDNMAGVFYMLLVAMGLSLL--VFAWEH 888

  Fly   839 FVMKKAHH 846
            .|..|..|
Zfish   889 LVYWKLRH 896

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIE	NP_001036733.1	PBP1_iGluR_Kainate	42..396	CDD:107377	59/286 (21%)
		ANF_receptor	51..382	CDD:279440	55/268 (21%)
		PBP2_iGluR_Kainate	419..790	CDD:270432	105/415 (25%)
		Lig_chan	551..824	CDD:278489	76/293 (26%)
grin2da	XP_009292354.1	PBP1_iGluR_NMDA_NR2	42..441	CDD:107373	61/293 (21%)
		PBP2_iGluR_NMDA_Nr2	452..851	CDD:270436	109/434 (25%)
		HisJ	<507..>590	CDD:223904	29/90 (32%)
		Lig_chan	605..877	CDD:278489	77/294 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591297
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.740