DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GluRIIE and grid2

DIOPT Version :9

Sequence 1:	NP_001036733.1	Gene:	GluRIIE / 318623	FlyBaseID:	FBgn0051201	Length:	897	Species:	Drosophila melanogaster
Sequence 2:	NP_001004123.1	Gene:	grid2 / 448841	ZFINID:	ZDB-GENE-040913-1	Length:	1009	Species:	Danio rerio

Alignment Length:	954	Identity:	243/954 - (25%)
Similarity:	431/954 - (45%)	Gaps:	160/954 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 YQSLESVP--------IGLLTDQNTEQMNIVFDHAI---DVANQEVGT-SLTSLKEEVNYGDAYQ 85
            :.|||..|        ||.:.|::.::.:.||..|:   ::.|:.:.| .:|...|.|:..:.:|
Zfish    13 FWSLEWEPVLPDSIIHIGAIFDESAKKDDEVFRMAVADLNLNNEILETEKITVSVEFVDGNNPFQ 77

  Fly    86 SYGKLCRMLETGIAGVFGPSSRHTAVHLMSICDAMDIPHIYSYMS--------------ENAEGF 136
            :..:.|.::..||..:.......:|..|.|:.|||.|||::...:              ...:.:
Zfish    78 AVQEACELMNRGILALVSSIGCMSAGSLQSLADAMHIPHLFIQRAPAGTPRSSCPPTTRAQPDDY 142

  Fly   137 NLHPH-PADLAKALYSLITEFNWTRFIFLYESAEYLNILNELTTMLGKSGTVITVLRYD----MQ 196
            .|... |..|...::.::.|:.|.:||..|::...:..:........:.|..:::.:.:    |.
Zfish   143 TLFVRPPVYLNDVIFQVVMEYTWQKFIIFYDTDYDIRGIENFLDQTSQQGMDVSLQKVESNINMM 207

  Fly   197 LNGNYK----QVLRRVRKSVDNRIVVVGSSETMPEFLNQAQQVGIINEDYKYIIGNLDFHSFDLE 257
            :.|.::    :.|.|.|.:: .|.|:..|..|...|:.:..:..::..|.::||.|.:....|::
Zfish   208 ITGMFRTMRVEELHRYRDTL-RRAVLFMSPATAKAFITEVVETNLVAFDCQWIIINEEISDMDVQ 271

  Fly   258 EYKYSEANITGLRLFSPEKMAVKELLMKLGYPTDQDEFRNGS------C----PITVEMALT--- 309
            |          |.:.|..::.:......|...|.|...||..      |    |....:.:|
Zfish   272 E----------LVMKSIGRLTLVRQTFPLPQNTSQRCVRNNHRINTSLCDPKDPKAQMLEITNRY 326

  Fly   310 -YDAVQLFAQT----LKNLPFKPMPQ-NCSQRTESVRDDGSSFKNYMRTLRLTDRLLTGPIYFEG 368
             ||.|.|.|.|    |::..:..|.. :|.::.......|.|....::...::.  ||..:.|..
Zfish   327 IYDTVLLLANTFHRKLEDRKWHSMASLSCIRKGSKPWQGGKSMLETVKKGGVSG--LTSLLEFND 389

  Fly   369 N-VRKGYHLDVI-----ELQPSGIVKVGTWDEDRQYRPQRLAPTTAQFDSVDNSLANKTFIILLS 427
            | .....|.:::     |.:..|:.::.|||      |......|.....::|::.. ..:.:::
Zfish   390 NGSNPNIHFEILGTNYGEDRGRGVSRLATWD------PIHGLNGTLTDRKLENNMRG-VVLRVVT 447

  Fly   428 VPNKPYAQLVETYKQLEGNSQYEGYGVDLIKELADKLGFNF-TFVNGGNDYGSYNKSTNESTGML 491
            |..:|:..:.|..  |....:|:|:.:|::..||:.|||.: .:|...:.||| .::.....|::
Zfish   448 VLEEPFVMVSENV--LGKPKKYQGFSIDVLDALANYLGFKYEIYVAPDHKYGS-QQADGTWNGLI 509

  Fly   492 REIMTGRADLAITDLTITSEREQALDFTIPFMNLGIAILYLKPQKATPELFTFMDPFSEEVWWFL 556
            .|::..|||:.::.||||.|||..:|||..:|:..:.:|..|.:: |.::|..:.||...:|..:
Zfish   510 GELVFKRADVGLSALTITPERESVVDFTTRYMDYSVGVLLRKAER-TVDMFACLAPFDLSLWACI 573

  Fly   557 GFSFLGVSLSFFILGRLSPSEWDNPYPCIEEPEELENQFTLGNSIWFTTGALLQQGSEIGPKALS 621
            ..:.|.|....::|      .|.|| |.:  |....:..||.||:||..|:.:|||.|:....|:
Zfish   574 AGTVLLVGTLVYLL------NWLNP-PRL--PMGSVSSTTLYNSMWFVYGSFVQQGGEVPYTTLA 629

  Fly   622 TRTVASFWWFFTLIVVSSYTANLAAFLTIEKPQSLINSVDDLADNKDGVVYGAKKTGSTRNFFMT 686
            ||.:...||.|.|||:|||||||||||||.:.::.|.|:.|||...| :.||.         .:.
Zfish   630 TRMMMGVWWLFALIVISSYTANLAAFLTISRIENSIQSLQDLAKQTD-LPYGT---------VLD 684

  Fly   687 SA---EERYKKMNKFMSENPQYL---------------TEDNMEGVNRVKTNTHYAFLMESTSIE 733
            ||   :.|.|.||.| ..:|.|.               .|::.||:.:||.. .:||:.::..:|
Zfish   685 SAVYDQVRSKGMNPF-ERDPMYSQMWRMINRTGGAENNVEESKEGIRKVKYG-RFAFVWDAAVLE 747

  Fly   734 Y--NTKRECNLKKIGDALDEKGYGIAMRKDWPHRGKFNNALLELQEQGVLEKMKNKWW------- 789
            |  ....:|:|..:.:.:.::|||:||:...|:|..|:..:||||:.|.::.:|.|||
Zfish   748 YVAINDEDCSLYTVSNNVADRGYGMAMQHGSPYRDIFSQRILELQQNGDMDILKLKWWPRDSPCD 812

  Fly   790 --NEVGTGICATKEDAPDATPLDMNNLEGVFFVLLVG---SCCALLYGIISWVLFVMKKAHHYRV 849
              :.|||        ....:.||:::..||||||..|   ||  |:..:.:|  :..:|..  ||
Zfish   813 LYSPVGT--------RKSGSALDIHSFAGVFFVLAAGVVLSC--LIATVETW--WTRRKGS--RV 863

  Fly   850 PLRDALKEEFQFVIDFNN-YVRVLKNSASIYSRSRQSSMSVASV 892
            |.::..||     ||..: :.||  ||......|.....|.:|:
Zfish   864 PSKEDDKE-----IDLEHLHHRV--NSLCTEDESPHKQFSTSSI 900

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIE	NP_001036733.1	PBP1_iGluR_Kainate	42..396	CDD:107377	79/405 (20%)
		ANF_receptor	51..382	CDD:279440	73/382 (19%)
		PBP2_iGluR_Kainate	419..790	CDD:270432	125/400 (31%)
		Lig_chan	551..824	CDD:278489	98/301 (33%)
grid2	NP_001004123.1	PBP1_iGluR_delta_2	28..427	CDD:107386	81/417 (19%)
		ANF_receptor	42..404	CDD:279440	72/374 (19%)
		PBP2_iGluR_delta_2	440..806	CDD:270449	124/391 (32%)
		Lig_chan	568..841	CDD:278489	98/301 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	989..1009
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591286
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.740