DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIE and GluRIB

DIOPT Version :9

Sequence 1:	NP_001036733.1	Gene:	GluRIIE / 318623	FlyBaseID:	FBgn0051201	Length:	897	Species:	Drosophila melanogaster
Sequence 2:	NP_001261621.2	Gene:	GluRIB / 44484	FlyBaseID:	FBgn0264000	Length:	1182	Species:	Drosophila melanogaster

Alignment Length:	992	Identity:	280/992 - (28%)
Similarity:	451/992 - (45%)	Gaps:	187/992 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LWSLFSIHISVNWAQYENFG------GYDNYQSL-ESVPIGLLTDQNTEQMNIVFDHAIDVANQE 66
            ||..|.:     |..:.:.|      |.....|| |.:|:|.:.:|.|:::...|.:|:...|..
  Fly    10 LWPSFLL-----WLTWSSGGGGGSGVGVSAQPSLTEKIPLGAIFEQGTDEVQSAFKYAMLNHNLN 69

  Fly    67 VGT---SLTSLKEEVNYGDAYQSYGKLCRMLETGIAGVFGPSSRHTAVHLMSICDAMDIPHIYSY 128
            |.:   .|.:..:.:|..||::....:|.....|:..:.|..|..:...|.|..:...:|.:..:
  Fly    70 VSSRRFELQAYVDVINTADAFKLSRLICNQFSRGVYSMLGAVSPDSFDTLHSYSNTFQMPFVTPW 134

  Fly   129 MSEN----AEGF-----NLHPHPADLAKALYSLITEFNWTRFIFLYESAEYLNILNELTTML--- 181
            ..|.    :.||     ::.|   |..:|:...|..:.|.:.|:||:|.:.|..|.::...|
  Fly   135 FPEKVLTPSSGFLDFALSMRP---DYHQAIIDTIQFYGWRKIIYLYDSHDGLLRLQQIYQGLRPG 196

  Fly   182 GKSGTVITVLRY-DMQLNGNYKQVLRRVRKSVDNRIVVVGSSETMPEFLNQ-AQQVGIINEDYKY 244
            .:|..|..|.|. ::.:...:...|.::.:..:..||:...:|...:.|.| .:.:.:....|.|
  Fly   197 NESFQVELVKRISNVSMAIEFLHTLEQIGRFENKHIVLDCPTEMAKQILIQHVRDLRLGRRTYHY 261

  Fly   245 IIGNLDFHS-FDLEEYKYSEANITGLRLFSPEKMAVKELLMKLGYPTDQDEFRNGSCPITVEMAL 308
            ::..|.... ::.|..::...||||.|:....:..|:|..........|.....|...|:.:.||
  Fly   262 LLSGLVMDDRWESEIIEFGAINITGFRIVDTNRRLVREFYDSWKRLDPQMSVGAGRESISAQAAL 326

  Fly   309 TYDA----VQLFAQTLKNLP--FKPMPQNCS------QRTESVRDDGSSF--------------- 346
            .|||    |:.|.:.|:..|  |:...|..|      |...|...||.::
  Fly   327 MYDAVFVLVEAFNKILRKKPDQFRNNVQRRSQTLMVAQAAASTSSDGYNYSASGGGGGNGGAGGG 391

  Fly   347 -----------------------------------KNYMRTLRLTDRLLTGPIYFEGNVRK-GYH 375
                                               ..|:|.:.:..  |||.|.|..:.|: .|.
  Fly   392 FAGSDSGGSGGMASRALDCNTAKGWVNAWEHGDKISRYLRKVEIEG--LTGDIKFNDDGRRVNYT 454

  Fly   376 LDVIELQ-PSGIVKVGTWDEDRQYRP-----QRLAPTTAQFDSVDNSLANKTFIILLSVPNKPYA 434
            |.|:|:. .|.:|||..|::|...:|     .||.| ..:|:.      |:|:|: .:|..:||.
  Fly   455 LHVVEMTVNSAMVKVAEWNDDAGLQPLNAKYVRLRP-HVEFEK------NRTYIV-TTVLEEPYI 511

  Fly   435 QL--VETYKQLEGNSQYEGYGVDLIKELADKLGFNF--TFVNGGNDYGSYNKSTNES-TGMLREI 494
            .|  |...::|.||:::|||..||...||.:||.|:  ..|..|| |||...|.:.. .||:.|:
  Fly   512 MLKQVAFGEKLHGNNRFEGYCKDLADLLAKELGINYELRLVKDGN-YGSEKSSAHGGWDGMVGEL 575

  Fly   495 MTGRADLAITDLTITSEREQALDFTIPFMNLGIAILYLKPQKATPELFTFMDPFSEEVWWFLGFS 559
            :...||:||..:|||:|||:.:||:.|||:|||:|:..||.|.||.:|:||:|.|:|:|..:.||
  Fly   576 VRKEADIAIAAMTITAERERVIDFSKPFMSLGISIMIKKPVKQTPGVFSFMNPLSQEIWVSVIFS 640

  Fly   560 FLGVSLSFFILGRLSPSEW----------DNPYPCIEEPEELENQ-------------------- 594
            ::|||:..|.:.|.||.||          .:|.|.... |:|.||
  Fly   641 YIGVSIVLFFVSRFSPHEWRLVQQQPQQSQSPDPHAHH-EQLANQQPPGIIGGAPLPAPPGPPTP 704

  Fly   595 --------------------------------FTLGNSIWFTTGALLQQGSEIGPKALSTRTVAS 627
                                            |::.||.||:..|.:|||.::.|:::|.|..|:
  Fly   705 GAQTAAGAAALQAALSAGSPGSGGSSSAVVNEFSVWNSFWFSLAAFMQQGCDLSPRSVSGRIAAA 769

  Fly   628 FWWFFTLIVVSSYTANLAAFLTIEKPQSLINSVDDLADNKDGVVYGAKKTGSTRNFFMTSAEERY 692
            .|:|||||::||||||||||||:|:..:.|||.:|||...: |.||....|||.:||..|....:
  Fly   770 SWFFFTLILISSYTANLAAFLTVERMVTPINSPEDLAMQTE-VQYGTLLHGSTWDFFRRSQIGLH 833

  Fly   693 KKMNKFMSENPQYLTEDNMEGVNRVKTNT-HYAFLMESTSIEY-NTKRECNLKKIGDALDEKGYG 755
            .||.::|:...........||:.||:.:. .||.|:||...|| |.:..|:..|:|..||.||:|
  Fly   834 NKMWEYMNSRKHVFVPTYDEGIKRVRNSKGKYALLVESPKNEYVNAREPCDTMKVGRNLDTKGFG 898

  Fly   756 IAMRKDWPHRGKFNNALLELQEQGVLEKMKNKWWNEVGTGICATKEDAPDA-TPLDMNNLEGVFF 819
            ||.......:...|.|:|.|:|.|.|.|::||||.|...  |:|.:|...: :.|.::|:.|:|:
  Fly   899 IATPLGSALKDPINLAVLTLKENGELIKLRNKWWYEKAE--CSTHKDGETSHSELSLSNVAGIFY 961

  Fly   820 VLLVGSCCALLYGIISW 836
            :|:.|...::...|:.:
  Fly   962 ILIGGLLVSVFVAILEY 978

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIE	NP_001036733.1	PBP1_iGluR_Kainate	42..396	CDD:107377	90/435 (21%)
		ANF_receptor	51..382	CDD:279440	82/411 (20%)
		PBP2_iGluR_Kainate	419..790	CDD:270432	162/439 (37%)
		Lig_chan	551..824	CDD:278489	112/337 (33%)
GluRIB	NP_001261621.2	PBP1_iGluR_AMPA	43..478	CDD:107375	92/439 (21%)
		ANF_receptor	55..461	CDD:279440	82/410 (20%)
		PBP2_iGluR_AMPA	497..938	CDD:270433	164/446 (37%)
		Lig_chan	632..967	CDD:278489	112/338 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462526
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	P	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.740