Protein Alignment GluRIIE and Ekar

DIOPT Version :10

• Sequence 1: NP_001036733.1
• Gene: GluRIIE / 318623
• FlyBaseID: FBgn0051201
• Length: 897
• Species: Drosophila melanogaster
• Sequence 2: NP_001036250.1
• Gene: Ekar / 43806
• FlyBaseID: FBgn0039916
• Length: 899
• Species: Drosophila melanogaster
• Alignment Length: 872
• Identity: 287/872 - (32%)
• Similarity: 449/872 - (51%)
• Gaps: 75/872 - (8%)

  Fly    39 VPIGLLTDQNTEQMN--IVFDHAIDVANQEVG----TSLTSLKEEVNYGDAYQSYGKLCRMLETG 97
            |.||.:........|  :.|.:||...|.:..    |::....|.||..|::::..|:|:::..|
  Fly    23 VRIGAIFSNQPGMYNSELAFRYAIHRLNMDKSLLPETTVDYYVEYVNRFDSFETVQKVCKLIRVG 87

  Fly    98 IAGVFGPSSRHTAVHLMSICDAMDIPHIYSYMSENAEGFNLHPHPAD--LAKALYSLITEFNWTR 160
            :..||.|:....|.|:.|||||:|||:|    ..:|..|:::.:|:.  :..|...:|...||||
  Fly    88 VQAVFSPTDSVLATHINSICDALDIPNI----GRSAHDFSINVYPSKQLVNYAFNDVIQYLNWTR 148

  Fly   161 FIFLYESAEYLNILNELTTMLGKSGTVITVLRYDMQLNGNYKQVLRRVR-KSVDNRIVVVGSSET 224
            |..|:|....:..|::|:........:..|.|      .:|...|...: |.:.|.|:...|:..
  Fly   149 FGILHEKENGIINLHQLSRSFHGEVHMRQVSR------DSYVSALNEFKGKEIHNIIIDTNSNGI 207

  Fly   225 MPEFLNQAQQVGIINE-DYKYIIGNLDFHSFDLEEYKYSEANITGLRLFSPEKMAVKELLMKLG- 287
            .....|..||.  :|| .|.|:..:.|..::|||::||:..|||..||.....:.||::|..:|
  Fly   208 SILLKNILQQQ--MNEYKYHYLFTSFDLETYDLEDFKYNFVNITSFRLVDTADVGVKQILKDIGL 270

  Fly   288 --YPTDQDEFRN----GSCPITVEMALTYDAVQLFA---QTLKNLPFKPMPQNCSQRTESVRDDG 343
              :...:..:.|    .|..:..|.||.:|:|.:||   |||:......: .|.|...|:..|.|
  Fly   271 YSHHIFKKPYLNLHIKKSTILESEPALMFDSVYVFAIGLQTLEQSHSLTL-LNISCEEENSWDGG 334

  Fly   344 SSFKNYMRTLRLTDRLLTGPIYFEGNVRKGYHLDVIELQPSGIVKVGTWDEDRQYRPQRLAPTTA 408
            .|..||:..:..  :.|||||.|:...|..:.||:|:|:...|||||.|      .|......|.
  Fly   335 LSLINYLNAVEW--KGLTGPIQFKDGQRVQFKLDLIKLKQHSIVKVGEW------TPHGHLNITE 391

  Fly   409 QFDSVDNSLANKTFIILLSVPNKPYAQLVETYKQLEGNSQYEGYGVDLIKELADKLGFNFTF-VN 472
            .....|....|.| ::::::...||. ::...|...||.::.|:.||:::.::.::||::.. :.
  Fly   392 PSMFFDAGSMNVT-LVVITILETPYV-MMHYGKNFTGNERFYGFCVDILETISREVGFDYILDLV 454

  Fly   473 GGNDYGSYNKSTNESTGMLREIMTGRADLAITDLTITSEREQALDFTIPFMNLGIAILYLKPQKA 537
            ....||:.:..|.|..||:.::|..:||||:..:|||..||..:|||.|||||||:||:..|...
  Fly   455 PDRKYGAKDPETGEWNGMVAQLMKYKADLAVGSMTITYARESVIDFTKPFMNLGISILFKVPTSE 519

  Fly   538 TPELFTFMDPFSEEVWWFLGFSFLGVSLSFFILGRLSPSEWDNPYPCIEEPEELENQFTLGNSIW 602
            ...||:||:|.:.|:|.::..::..|||..:|:|:|||.||.....|..|...:.|||:|.:|.|
  Fly   520 PTRLFSFMNPLAIEIWIYVLIAYFLVSLCIYIVGKLSPIEWKCINACDLENISIGNQFSLTDSFW 584

  Fly   603 FTTGALLQQGSEIGPKALSTRTVASFWWFFTLIVVSSYTANLAAFLTIEKPQSLINSVDDLADNK 667
            ||.|..:||..:|.|:|:|||.::|.|.||:||:|:|||||||||||.|:..:.|.:.:|||...
  Fly   585 FTIGTFMQQSPDIYPRAMSTRIISSTWGFFSLIIVASYTANLAAFLTTERMINPIENAEDLASQT 649

  Fly   668 DGVVYGAKKTGSTRNFFMTSAEERYKKMNKFM-SENPQYLTEDNMEGVNRVKTNTHYAFLMESTS 731
            : :.||...:|||..||..|..|.|||:.:.| ::.|...|....:|:.||... :||||||||.
  Fly   650 E-ISYGTLDSGSTMTFFRDSVIETYKKIWRSMDNKKPSAFTTTYEDGIKRVNQG-NYAFLMESTM 712

  Fly   732 IEYNTKRECNLKKIGDALDEKGYGIAMRKDWPHRGKFNNALLELQEQGVLEKMKNKWWNEVGTGI 796
            ::|..:|:|||.:||..||.||||||..|..|.|.|.:.|:|||||:|.::.:.:|||..... .
  Fly   713 LDYIVQRDCNLTQIGGLLDTKGYGIATPKGSPWRDKISLAILELQERGDIQMLYDKWWKNTDE-T 776

  Fly   797 CATKEDAPD--ATPLDMNNLEGVFFVLLVGSCCALLYGIIS-WVLF------------------- 839
            |..|..:..  |..|.:.::.|||.||:.|...|.:..... |..|
  Fly   777 CTRKNTSKQSKANSLGLESIGGVFVVLIAGIIVAAVVAFFEFWYNFRYNYEATPSQSVVNNKYNQ 841

  Fly   840 --VMKKAHHYRVPLRD---ALKEEFQF 861
              :::...:|..|.|.   .:.||.::
  Fly   842 DGILESERNYTPPDRSFWIEIAEELRY 868

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIE	NP_001036733.1	PBP1_iGluR_Kainate	40..402	CDD:380605	111/381 (29%)
		PBP2_iGluR_Kainate	419..790	CDD:270432	154/372 (41%)
		Lig_chan	551..824	CDD:459656	118/275 (43%)
Ekar	NP_001036250.1	PBP1_iGluR_Kainate	24..390	CDD:380605	111/386 (29%)
		PBP2_iGluR_Kainate	402..771	CDD:270432	154/372 (41%)
		Lig_chan	532..806	CDD:459656	118/276 (43%)