DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIE and Ir93a

DIOPT Version :9

Sequence 1:	NP_001036733.1	Gene:	GluRIIE / 318623	FlyBaseID:	FBgn0051201	Length:	897	Species:	Drosophila melanogaster
Sequence 2:	NP_650924.3	Gene:	Ir93a / 42471	FlyBaseID:	FBgn0259215	Length:	868	Species:	Drosophila melanogaster

Alignment Length:	839	Identity:	188/839 - (22%)
Similarity:	329/839 - (39%)	Gaps:	211/839 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   102 FGPSSRHTAVHLMSICD----------AMDIPHIYSYMSENAEGFNLHPHPADLAKALYSLITEF 156
            |..:::.|::.|::|.|          |:.:|.:     ||.:.|     |..:..|....|  .
  Fly   109 FYKNTQETSILLIAITDSDCPRLPLNRALMVPIV-----ENGDEF-----PQLILDAKVQQI--L 161

  Fly   157 NW-TRFIF-----------LYESAEYLNILNELTTMLGKSGTVITVLRYDM--QLNGNYKQV-LR 206
            || |..:|           |.:|..:.:|.|.:|.        |:::.|::  .|.|..|:| ||
  Fly   162 NWKTAVVFVDQTILEENALLVKSIVHESITNHITP--------ISLILYEINDSLRGQQKRVALR 218

  Fly   207 RV------RKSVDNRIVVVGSSETMPEFLNQAQQVGIINEDYKYIIGNLDF--HSFD-------L 256
            :.      :|..:.|...:..|....:.:..|:.:.:.:...:::|..||.  ..||       |
  Fly   219 QALSQFAPKKHEEMRQQFLVISAFHEDIIEIAETLNMFHVGNQWMIFVLDMVARDFDAGTVTINL 283

  Fly   257 EEYKYSEANITGLRLFSPEKMAVKELLMKLGYPTDQDEFR-----------NGSCPITVEMALTY 310
            :|    .|||.         .|:.|.     .|..||...           |....||||....|
  Fly   284 DE----GANIA---------FALNET-----DPNCQDSLNCTISEISLALVNAISKITVEEESIY 330

  Fly   311 --------DAVQLF-----AQTLKNL-PFKPMPQNCSQ----RTESVRDDGSSFKNYMRTLRLTD 357
                    :|::..     |:.|:.: .|......||.    |.|:....|.|.:|  |..|.|.
  Fly   331 GEISDEEWEAIRFTKQEKQAEILEYMKEFLKTNAKCSSCARWRVETAITWGKSQEN--RKFRSTP 393

  Fly   358 RLLTGPIYFEGNVRKGYHLDVIELQPSGIVKVGTWDEDRQYRPQRLAPTTAQFDSVDNSLANKTF 422
            :.......||                  .:.:|.|.....:..|.||     |..:::...|.|.
  Fly   394 QRDAKNRNFE------------------FINIGYWTPVLGFVCQELA-----FPHIEHHFRNITM 435

  Fly   423 IILLSVPNKPYAQLVETYKQLEGNS-----QYEGYGVDLIKELADKLGFNFTFVNGG----NDYG 478
            .| |:|.|.|:..|.:       ||     :::|..::::|||:..|.|::......    .|..
  Fly   436 DI-LTVHNPPWQILTK-------NSNGVIVEHKGIVMEIVKELSRALNFSYYLHEASAWKEEDSL 492

  Fly   479 SYNKSTNESTGMLREIMTGRADLAITDL-------------TITSEREQALDFTIPFMNLGIAIL 530
            |.:...|||..::.. ||.|....:.::             |:....::..::|.|......:.:
  Fly   493 STSAGGNESDELVGS-MTFRIPYRVVEMVQGNQFFIAAVAATVEDPDQKPFNYTQPISVQKYSFI 556

  Fly   531 YLKPQKATPELFTFMDPFSEEVWWFLGFSFLGVSL----SFFILGRLSPSEWDNPYPCIEEPEEL 591
            ..||.:.: .::.|..||:.|.|    |..:|:.|    :.:.:.||:|         ::| ..:
  Fly   557 TRKPDEVS-RIYLFTAPFTVETW----FCLMGIILLTAPTLYAINRLAP---------LKE-MRI 606

  Fly   592 ENQFTLGNSIWFTTGALLQQGSEIGPKALSTRTVASFWWFFTLIVVSSYTANLAAFLTIEKPQSL 656
            ....|:.:..|:..|||||||....|.|.|.|.|..|||...:::|::|..||.||||..|.|..
  Fly   607 VGLSTVKSCFWYIFGALLQQGGMYLPTADSGRLVVGFWWIVVIVLVTTYCGNLVAFLTFPKFQPG 671

  Fly   657 INSVDDLADNKDGVVYGAKKTGSTRNFFMTSAEERYKKMNKFMSENPQY--LTEDNMEGVNR-VK 718
            ::.::.|.|:||.|.||.:.......:..::..|.:|   .::.....|  ..|:::|.|.| .:
  Fly   672 VDYLNQLEDHKDIVQYGLRNGTFFERYVQSTTREDFK---HYLERAKIYGSAQEEDIEAVKRGER 733

  Fly   719 TNTHYAF-LMESTSIEYNTKRECNLKKIG--DALDEKGYGIAM----RKDWPHRGKFNNALLELQ 776
            .|..:.. |.......:..::||:. .:|  ..:||:   |||    :..:.|  ..|..:..:.
  Fly   734 INIDWRINLQLIVQRHFEREKECHF-ALGRESFVDEQ---IAMIVPAQSAYLH--LVNRHIKSMF 792

  Fly   777 EQGVLEKMKNKWWNEV---GTGICATKEDAPDAT--PLDMNNLEGVFFVLLVGSCCALL 830
            ..|.:|:     |:::   ..|.|..|......|  .::|::::|.|.|||:|...|||
  Fly   793 RMGFIER-----WHQMNLPSAGKCNGKSAQRQVTNHKVNMDDMQGCFLVLLLGFTLALL 846

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIE	NP_001036733.1	PBP1_iGluR_Kainate	42..396	CDD:107377	73/362 (20%)
		ANF_receptor	51..382	CDD:279440	71/348 (20%)
		PBP2_iGluR_Kainate	419..790	CDD:270432	96/406 (24%)
		Lig_chan	551..824	CDD:278489	75/291 (26%)
Ir93a	NP_650924.3	Periplasmic_Binding_Protein_Type_2	429..>697	CDD:328725	75/291 (26%)
Ir93a	NP_650924.3	Lig_chan	576..836	CDD:306551	72/287 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462818
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940