DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIE and gria4a

DIOPT Version :9

Sequence 1:	NP_001036733.1	Gene:	GluRIIE / 318623	FlyBaseID:	FBgn0051201	Length:	897	Species:	Drosophila melanogaster
Sequence 2:	NP_999971.1	Gene:	gria4a / 407735	ZFINID:	ZDB-GENE-020125-7	Length:	898	Species:	Danio rerio

Alignment Length:	859	Identity:	284/859 - (33%)
Similarity:	456/859 - (53%)	Gaps:	53/859 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 SVPIGLLTDQNTEQMNIVFDHAIDVAN-----QEVGTSLTSLKEEVNYGDAYQSYGKLCRMLETG 97
            ||.||.|..:||:|....|..||.:.|     .|...:|....:.:...:::......|.....|
Zfish    21 SVQIGGLFIRNTDQEYTAFRLAIFLHNTSPNATEAPFNLVPHVDNIETANSFAVTNAFCSQYSRG 85

  Fly    98 IAGVFGPSSRHTAVHLMSICDAMDIPHIY-SYMSENAEGFNLHPHPADLAKALYSLITEFNWTRF 161
            :..:||...:.:...|.|.|.|:.|..:. |:.:|....|.|...|: :..||.||:..::|:||
Zfish    86 VFAIFGLYDKRSVHTLTSFCSALHISLVTPSFPAEGETQFVLQLRPS-IRGALLSLLDHYDWSRF 149

  Fly   162 IFLYESAEYLNILNELTTMLGKSGTVITVLRYDMQLNGNYKQVLRRVRKSVDNRIVVVGSSETMP 226
            :|||::.....:|..:....|::|..::.:..:...:.:|:::|..:.:..:.:.|:...:|.:.
Zfish   150 VFLYDTDRGYAVLQAIMEKAGQNGWQVSAICVENFNDASYRRLLEDLDRRQEKKFVIDLEAERLQ 214

  Fly   227 EFLNQAQQVGIINEDYKYIIGNLDFHSFDLEEYKYSEANITGLRLFSPEK-MAVKELLMKLGYPT 290
            ..|.|...||...:.|.||:.||.|....||.:.:..||:||.:|....| |.:|  ||:.....
Zfish   215 NILEQIVSVGKHVKGYHYIVANLGFKDISLERFMHGGANVTGFQLVDFSKPMVIK--LMQRWNKL 277

  Fly   291 DQDEFRNGSCPITVEMALTYDAVQLFAQTLKNLPFKPM-------PQNCSQRTESVRDDGSSFKN 348
            ||.|:.....|.....:||||.|.:.|:..:||..:.:       ..:|.....:..:.|...:.
Zfish   278 DQREYPGSESPPRYTSSLTYDGVLVMAEAFRNLRRQKIDISRRGNAGDCLANPAAPWNQGIDMER 342

  Fly   349 YMRTLRLTDRLLTGPIYFEGNVRK-GYHLDVIELQPSGIVKVGTW-DEDRQYRPQRLAPTTAQFD 411
            .::.:|:..  |||.|.|:...|: .|.:||.||:.:|..|:|.| |.|:....|.....
Zfish   343 TLKQVRIQG--LTGNIQFDHYGRRVNYTMDVFELKSNGPRKIGYWNDLDKLVLVQNELSM----- 400

  Fly   412 SVDNSLANKTFIILLSVPNKPYAQLVETYKQLEGNSQYEGYGVDLIKELADKLG--FNFTFVNGG 474
            ..|:::.|:| :|:.::...||..|.:.::..|||.|:|||.|||..|:|..:|  :..:.|..|
Zfish   401 GNDSAMENRT-VIVTTIMEGPYVMLKKNWEMYEGNEQFEGYCVDLASEVAKHIGIKYKISIVLDG 464

  Fly   475 NDYGSYNKSTNESTGMLREIMTGRADLAITDLTITSEREQALDFTIPFMNLGIAILYLKPQKATP 539
            . ||:.:..|....||:.|::.|:|::|:..|.||..||:.:||:.|||:|||:|:..||||:.|
Zfish   465 K-YGARDPETKIWNGMVGELVYGKAEIAVAPLAITLVREEVIDFSKPFMSLGISIMIKKPQKSKP 528

  Fly   540 ELFTFMDPFSEEVWWFLGFSFLGVSLSFFILGRLSPSEWDNPYPCIEEPEE---------LENQF 595
            .:|:|:||.:.|:|..:.|:::|||:..|::.|.||.||..     |||||         ..|:|
Zfish   529 GVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHT-----EEPEEGSDGPPSDQPPNEF 588

  Fly   596 TLGNSIWFTTGALLQQGSEIGPKALSTRTVASFWWFFTLIVVSSYTANLAAFLTIEKPQSLINSV 660
            .:.||:||:.||.:|||.:..|::||.|.|...|||||||::||||||||||||:|:..|.|.|.
Zfish   589 GIFNSLWFSLGAFMQQGCDFTPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESA 653

  Fly   661 DDLADNKDGVVYGAKKTGSTRNFFMTSAEERYKKMNKFM-SENPQYLTEDNMEGVNRV-KTNTHY 723
            :|||...: :.||...:|||:.||..|....|:||..:| |..|...|:...|||.|| |:...|
Zfish   654 EDLAKQTE-IAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKSAEPTVFTKTTAEGVARVRKSKGKY 717

  Fly   724 AFLMESTSIEYNTKRE-CNLKKIGDALDEKGYGIAMRKDWPHRGKFNNALLELQEQGVLEKMKNK 787
            |||:|||..||..:|: |:..|:|..||.||||:|..|........|.|:|:|.|.|||:|:|||
Zfish   718 AFLLESTMNEYTEQRKPCDTMKVGGNLDSKGYGVATPKGSQLGTPVNLAVLKLSEAGVLDKLKNK 782

  Fly   788 WWNEVGTGICATKEDA---PDATPLDMNNLEGVFFVLLVGSCCALLYGIISWVLFVMKKAHHYRV 849
            ||.:.|.  |..|:..   ..:..|.::|:.|||::|:.|...|:|..::.:......:|...::
Zfish   783 WWYDKGE--CGPKDSGSKDKSSQALSLSNVAGVFYILVGGLGLAMLVALVEFCYKSRAEAKKLKL 845

  Fly   850 PLRDALKEEFQFVI 863
            ...:|::.:.:..|
Zfish   846 TFSEAMRNKARLSI 859

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIE	NP_001036733.1	PBP1_iGluR_Kainate	42..396	CDD:107377	95/369 (26%)
		ANF_receptor	51..382	CDD:279440	85/345 (25%)
		PBP2_iGluR_Kainate	419..790	CDD:270432	167/384 (43%)
		Lig_chan	551..824	CDD:278489	124/287 (43%)
gria4a	NP_999971.1	PBP1_iGluR_AMPA_GluR4	23..393	CDD:107383	97/374 (26%)
		ANF_receptor	34..375	CDD:279440	85/345 (25%)
		PBP2_iGluR_AMPA_GluR4	408..790	CDD:270445	169/391 (43%)
		Lig_chan	540..821	CDD:278489	124/288 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591304
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.850