DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIE and gria1b

DIOPT Version :9

Sequence 1:	NP_001036733.1	Gene:	GluRIIE / 318623	FlyBaseID:	FBgn0051201	Length:	897	Species:	Drosophila melanogaster
Sequence 2:	NP_991293.1	Gene:	gria1b / 403044	ZFINID:	ZDB-GENE-020125-2	Length:	917	Species:	Danio rerio

Alignment Length:	867	Identity:	274/867 - (31%)
Similarity:	441/867 - (50%)	Gaps:	105/867 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 SVPIGLLTDQNTEQMNIVFDHAIDVANQEVGTSLTSLKEEVNYGDAYQSYGKLCRMLETGIAGVF 102
            ::.||.|...::.:.: ||..|:...|..  ..|....:.|:.|.::......|.....|:..:.
Zfish    24 NINIGGLFPTDSHEYD-VFRFALSQHNDV--PKLVPQVDMVDTGSSFAMTYAFCSQFSKGVYAII 85

  Fly   103 GPSSRHTAVHLMSICDAMDIPHIY-SYMSENAEGFNLHPHPADLAKALYSLITEFNWTRFIFLYE 166
            |...|.|...|||.|.|:.:..:. |:..:....|.:...| :|..||.:|:..:.|.:|:::|.
Zfish    86 GLYDRKTMNMLMSFCGALHVCFVTPSFPIDTNNQFVIQLRP-ELQDALIALVEHYKWNKFVYMYS 149

  Fly   167 SAEYLNILNELTTMLGKSGTVITVLRYDMQLNGNYKQVLRRVRKSVDNRIVVVGSSETMPEFLN- 230
            |...|.:|.::.....:....:|.:.:|......:.:.::.:....:.:|::....|.:...||
Zfish   150 SDSGLTVLQKILDTAAEKTWQVTSINFDTLTEAAFLKAIQDLDNKKEFKIILDCELERLNSILNL 214

  Fly   231 -QAQQVGIINEDYKYIIGNLDFHSFDLEEYKYSEANITGLRLFSPEKMAVKELLMK-LGYPTDQD 293
             .||:..:.|  |.||:.||.|...:|.|::...||:||.:|.:.....|...:.. |.:  |..
Zfish   215 IAAQKKNLKN--YHYILANLGFLDLNLTEFRKGGANVTGFQLMNYTNPTVSRTIQDWLEF--DSK 275

  Fly   294 EFRNGSCPITVEMALTYDAVQLFAQTLKNL-------------------PFKPMPQNCS-QRT-E 337
            :.::....:....|||||.|.:.|...:||                   |..|..|... ||. :
Zfish   276 DLKSPKRRLKYTGALTYDGVTVMATAFQNLRKQRIDISRRGNAGECLANPPAPWGQGIDIQRALQ 340

  Fly   338 SVRDDGSSFKNYMRTLRLTDRLLTGPIYF--EGNVRKGYHLDVIELQPSGIVKVGTWDEDRQYRP 400
            .|:.:|                |||.:.|  :|: |..:.:.|:|..|||..|||.|::..:|
Zfish   341 QVQFEG----------------LTGHVQFNDKGH-RTNFTVSVMEFGPSGPKKVGYWNQREKY-- 386

  Fly   401 QRLAPTTAQFDSVDN---SLANKTFIILLSVPNKPYAQLVETYKQLEGNSQYEGYGVDLIKELAD 462
                .:||.:.::.|   .|.|:|::: .::...||..|.:.::||.||.:||||.|:|..|:|.
Zfish   387 ----VSTATYSNMLNETFGLQNRTYVV-TTILEAPYVMLKKNHEQLVGNDKYEGYCVELAAEIAK 446

  Fly   463 KLGFNFTF-VNGGNDYGSYNKSTNESTGMLREIMTGRADLAITDLTITSEREQALDFTIPFMNLG 526
            .:|:::.. :.|...||:.:..|....||:.|::.|:||:|:..||||..||:.:||:.|||:||
Zfish   447 HVGYSYRLELVGDGKYGARDAETMMWNGMVGELVYGKADVAVAPLTITLVREEVIDFSKPFMSLG 511

  Fly   527 IAILYLKPQKATPELFTFMDPFSEEVWWFLGFSFLGVSLSFFILGRLSPSEW------------D 579
            |:|:..||.|:.|.:|:|:||.:.|:|..:.|:::|||:..|::.|.||.||            :
Zfish   512 ISIMIKKPTKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHADDEEETADQQN 576

  Fly   580 NPYPCIEEPEELENQ------------------FTLGNSIWFTTGALLQQGSEIGPKALSTRTVA 626
            ...|...||.:..||                  |.:.||:||:.||.:|||.:|.|::||.|.|.
Zfish   577 QNQPPSPEPNQSPNQSQNQREEKQEKQPEHTNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVG 641

  Fly   627 SFWWFFTLIVVSSYTANLAAFLTIEKPQSLINSVDDLADNKDGVVYGAKKTGSTRNFFMTSAEER 691
            ..|||||||::||||||||||||:|:..|.|.|.:|||...: :.||....|||:.||..|....
Zfish   642 GVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTE-IAYGTLDGGSTKEFFRRSKIAV 705

  Fly   692 YKKMNKFM-SENPQYLTEDNMEGVNRV-KTNTHYAFLMESTSIEYNTKRE-CNLKKIGDALDEKG 753
            ::||..:| |..|....:...|||.|| |:...||:|:|||..||..:|: |:..|:|..||.||
Zfish   706 FEKMWSYMKSAEPTVFVKTTDEGVVRVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKG 770

  Fly   754 YGIAMRKDWPHRGKFNNALLELQEQGVLEKMKNKWW---NEVGTGICATKEDAPDAT-PLDMNNL 814
            ||:|..|....|...|.|:|:|.|||:|:|:|||||   .|.|:|    ..|:.|.| .|.::|:
Zfish   771 YGVATPKGSALRNPVNLAVLKLNEQGLLDKLKNKWWYDKGECGSG----GGDSKDKTSALSLSNV 831

  Fly   815 EGVFFVLLVGSCCALLYGIISW 836
            .|||::|:.|...|:|..::.:
Zfish   832 AGVFYILIGGLGLAMLVALVEF 853

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIE	NP_001036733.1	PBP1_iGluR_Kainate	42..396	CDD:107377	88/380 (23%)
		ANF_receptor	51..382	CDD:279440	79/357 (22%)
		PBP2_iGluR_Kainate	419..790	CDD:270432	165/407 (41%)
		Lig_chan	551..824	CDD:278489	125/309 (40%)
gria1b	NP_991293.1	PBP1_iGluR_AMPA_GluR1	26..387	CDD:107385	90/391 (23%)
		ANF_receptor	41..368	CDD:279440	77/350 (22%)
		PBP2_iGluR_AMPA_GluR1	404..812	CDD:270447	165/409 (40%)
		Lig_chan	536..842	CDD:278489	125/310 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591283
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.750