DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIE and Ir75c

DIOPT Version :9

Sequence 1:	NP_001036733.1	Gene:	GluRIIE / 318623	FlyBaseID:	FBgn0051201	Length:	897	Species:	Drosophila melanogaster
Sequence 2:	NP_649013.3	Gene:	Ir75c / 39983	FlyBaseID:	FBgn0261401	Length:	623	Species:	Drosophila melanogaster

Alignment Length:	780	Identity:	168/780 - (21%)
Similarity:	266/780 - (34%)	Gaps:	256/780 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   149 LYSLITEFNWTRFIFLYESAEYLNILN-------------ELTTMLGKSGTVITVLRYDMQLNGN 200
            ||.||. ||      |.|    :|:.|             .|..||.::|.....:  |:|...|
  Fly     6 LYRLIV-FN------LLE----INLSNLMVFHCWSIKEAFPLVEMLNQNGIFSQYI--DVQNPDN 57

  Fly   201 YKQVLRRVRKS-VDNRIVVVG-----SSETMPEFLNQAQQVGIINEDYKYIIGNLDFHSFDLEEY 259
                |..|.|. :|:.:|.:|     ..:......||:.:..:.|::..:::
  Fly    58 ----LANVHKEYLDSDLVRLGVFLDLGCDKAELVTNQSSRARLYNQNLHWLL------------- 105

  Fly   260 KYSEA-NITGL-RLFSPEKMAVKELLMKLGYPTDQDEFR-------------NGSCPITVEMALT 309
             |.|| |.|.| :||....::   |...:.|.:.:||.|             .|...|||:
  Fly   106 -YDEAGNFTKLTQLFEGANLS---LNADVTYVSREDEERFILHDVYNKGSHLGGKLNITVD---- 162

  Fly   310 YDAVQLFAQTLKNLPFKPMPQNCSQRTESVRDDGSSFKNYMRTLRLTDRLLTGPIYFEGNVRKGY 374
                    |||:          |::....|       |.|:..|.|..||
  Fly   163 --------QTLQ----------CNRSHCQV-------KEYLSELHLRPRL--------------- 187

  Fly   375 HLDVIELQPSGIVKVGTWDEDRQYRPQRLAPTTAQFDSVDNSLANKTFII--LLSV-P-NKPYAQ 435
                                  |:|               ..|::.||.:  |:|| | |....:
  Fly   188 ----------------------QHR---------------MDLSSVTFRLAALVSVLPINSSEEE 215

  Fly   436 LVETYKQLEGNSQYEGY-------GVDLIKELADKLGFNFTFVNGG----NDY--GSYNKSTNES 487
            |:|..     ||..:.:       |..||....:.|||...::..|    .|.  |:....||||
  Fly   216 LLEFL-----NSDRDSHMDSISRIGNRLIMHTQEILGFKLHYIWCGTWSVQDAFGGAIGMLTNES 275

  Fly   488 TGMLREIMTGRADLAITDLTITSEREQALDFTIPFMNLGIAILYLKPQKATPELFTFMDPFSEEV 552
                       |:|..|....:..|...|.............::..|..|..:...|::||...|
  Fly   276 -----------AELCTTPFVPSWNRLHYLHPMTEQAQFRAVCMFRTPHNAGIKAAVFLEPFMPSV 329

  Fly   553 WW-FLG-FSFLGVSL-SFFILGRLSPSEWDNPYPCIEEPEELENQF--TLGNSIWFTTGALLQQG 612
            |: |.| ..|.||.| ..|.|.|    .|  ...|::        |  :|.:|...:.||...||
  Fly   330 WFAFAGLLIFAGVLLWMIFHLER----HW--MQRCLD--------FIPSLLSSCLISFGAACIQG 380

  Fly   613 SEIGPKALSTRTVASFWWFFTLIVVSSYTANLAAFLTIEKPQSLINSVDDLADNKDGVVYGAKKT 677
            |.:.||:...|.........:.::.:.||:.:.:.|.....:|.|.::..|||:...|  |....
  Fly   381 SYLMPKSAGGRLAFIAVMLTSFLMYNYYTSIVVSTLLGSPVRSNIRTIQQLADSSLDV--GFDTV 443

  Fly   678 GSTRNFFMTSAEERYKKMNKFMSE-----NPQYLTEDNMEGVNRVKTNTHYAFLMESTSIEYNTK 737
            ..|:.:.::|.....:.:.|...|     |..:|:.:  |||.||:....:.:..|::.:.:..:
  Fly   444 PFTKTYLVSSPRPDIRSLYKQKVESKRDPNSVWLSPE--EGVIRVRDQPGFVYTSEASFMYHFVE 506

  Fly   738 RECNLKKIGDALDEKGYGIAMRKDWPHRG------KFNNALLELQ----EQGVLEK--------- 783
            :....::|.| |:|    |.:|.:....|      .:...|.:||    |.|:..|
  Fly   507 KHYLPREISD-LNE----IILRPESAVYGMVHLNSTYRQLLTQLQVRMLETGITSKQSRFFSKTK 566

  Fly   784 ---MKNKWWNEVGTGICATKEDAPDATPLDMNNLEGVFFVLLVGSCCALLYGI--ISWVLFVMKK 843
               ..|.:..:||...         |.||        |..|||....|||..|  |.|..:..||
  Fly   567 LHTFSNSFVIQVGMEY---------AAPL--------FISLLVAYFLALLILILEICWARYAKKK 614

Fly 844 843
Fly 615 614

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIE	NP_001036733.1	PBP1_iGluR_Kainate	42..396	CDD:107377	54/280 (19%)
		ANF_receptor	51..382	CDD:279440	54/266 (20%)
		PBP2_iGluR_Kainate	419..790	CDD:270432	94/419 (22%)
		Lig_chan	551..824	CDD:278489	68/304 (22%)
Ir75c	NP_649013.3	Lig_chan	328..553	CDD:306551	57/247 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462737
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840