DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIE and Ir40a

DIOPT Version :9

Sequence 1:	NP_001036733.1	Gene:	GluRIIE / 318623	FlyBaseID:	FBgn0051201	Length:	897	Species:	Drosophila melanogaster
Sequence 2:	NP_610140.4	Gene:	Ir40a / 35449	FlyBaseID:	FBgn0259683	Length:	732	Species:	Drosophila melanogaster

Alignment Length:	744	Identity:	162/744 - (21%)
Similarity:	276/744 - (37%)	Gaps:	170/744 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   235 VGIINEDYKYIIGNLDFHSFDLEEYKYSEANIT-GLRLFSPEKMAVKELLMKLGYPTDQDEFRNG 298
            :|::|......|||      |..:...:...|. ||:..|...:|:..|.:.           :|
  Fly    14 LGLLNSTRLTFIGN------DESDTAIALTQIVRGLQQSSLAILALPSLALS-----------DG 61

  Fly   299 SCPITVEMAL----------TYDAVQLFAQTLKNLPFKPMPQNCSQRTESVR---DDGSSFKNYM 350
            .|.....:.|          .|.:| :|:||  .|.|:.:.:|.....|.:.   |:.:...|.:
  Fly    62 VCQKERNVYLDDFLQRLHRSNYKSV-VFSQT--ELFFQHIEENLQGANECISLILDEPNQLLNSL 123

  Fly   351 RTLRLTDRLLTGPIY-------------FEGNVR---------KGYHLDVIELQP---SGIVKVG 390
            ....|..||.....|             |...:|         |.:.:...:.:|   |.:..|.
  Fly   124 HDRHLGHRLSLFIFYWGARWPPSSRVIRFREPLRVVVVTRPRKKAFRIYYNQARPCSDSQLQLVN 188

  Fly   391 TWDEDR---QYRPQRLAPTTAQFDSVDNSLANKTFIILLSVP---NKPYAQLVETYKQLEGNSQY 449
            .:|.|.   |..|  |.||..   ||..:...:||    .||   :.|:..:.......|.:.::
  Fly   189 WYDGDNLGLQRIP--LLPTAL---SVYANFKGRTF----RVPVFHSPPWFWVTYCNNSFEEDEEF 244

  Fly   450 EGY------------GVD--LIKELADKLGFNFTFVNG-GNDYGSY----NKSTNES-TGMLREI 494
            ...            |.|  |:..|:..:.|.|.::.. |...||.    .|.:|:| ||.:..:
  Fly   245 NSLDSIEKRKVRVTGGRDHRLLMLLSKHMNFRFKYIEAPGRTQGSMRSEDGKDSNDSFTGGIGLL 309

  Fly   495 MTGRADLAITDLTITSEREQALDFTIPFMNLGIAILYLKPQKATPELFTFMDPFSEEVW------ 553
            .:|:||..:.|:.::.||.:|::|:...:....|.....|::.. |....|.||.:::|
  Fly   310 QSGQADFFLGDVGLSWERRKAIEFSFFTLADSGAFATHAPRRLN-EALAIMRPFKQDIWPHLILT 373

  Fly   554 -WFLGFSFLGVSLSFFILGRLSPSEWDNPYPCIEEPEELENQFT--------------------- 596
             .|.|..|.|:....:|..|    .|.|  ..:|...||....|
  Fly   374 IIFSGPIFYGIIALPYIWRR----RWAN--SDVEHLGELYIHMTYLKEITPRLLKLKPRTVLSAH 432

  Fly   597 ------LGNSIWFTTGALLQQG-SEI--GPKALSTRTVASFWWFFTLIVVSSYTANLAAFLTIEK 652
                  ....||||....|:|. :|:  |.:|.....|  :|...|.::...|:|.|.:......
  Fly   433 QMPHQLFQKCIWFTLRLFLKQSCNELHNGYRAKFLTIV--YWIAATYVLADVYSAQLTSQFARPA 495

  Fly   653 PQSLINSVDDL--ADNKDGVVYGAKKTGSTRNFFMTSAE---ERYKKMNKFMSENPQYLTEDNME 712
            .:..||::..|  |...||.....:|..|:........|   :.|..|.:.:..:||....|::|
  Fly   496 REPPINTLQRLQAAMIHDGYRLYVEKESSSLEMLENGTELFRQLYALMRQQVINDPQGFFIDSVE 560

  Fly   713 -GVNRV-KTNTHYAFLMESTSIEYNTKR-ECNLKKIGDALDEKGYGIAMRKDWPHRGKFNNALLE 774
             |:..: :.....|.|....::.:|.:: ..|..::...|..:...:|::...|..|..||.|::
  Fly   561 AGIKLIAEGGEDKAVLGGRETLFFNVQQYGSNNFQLSQKLYTRYSAVAVQIGCPFLGSLNNVLMQ 625

  Fly   775 LQEQGVLEKMK----NKWWNEV-GTGI-----------CATKEDAPDAT---PLDMNNLEGVFFV 820
            |.|.|:|:||.    .|.:.|| .|.|           ..::.::.|:|   ||::..|:|.|..
  Fly   626 LFESGILDKMTAAEYAKQYQEVEATRIYKGSVQAKNSEAYSRTESYDSTVISPLNLRMLQGAFIA 690

  Fly   821 LLVGSCCALLYGIISWVLFVMKKAHHYRV 849
            |.|||..|   |:|..:..|..|....|:
  Fly   691 LGVGSLAA---GVILLLEIVFIKLDQARL 716

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIE	NP_001036733.1	PBP1_iGluR_Kainate	42..396	CDD:107377	37/199 (19%)
		ANF_receptor	51..382	CDD:279440	33/182 (18%)
		PBP2_iGluR_Kainate	419..790	CDD:270432	96/442 (22%)
		Lig_chan	551..824	CDD:278489	74/336 (22%)
Ir40a	NP_610140.4	PBP2_LTTR_substrate	216..338	CDD:330233	28/125 (22%)
		Periplasmic_Binding_Protein_Type_2	297..>391	CDD:328725	23/94 (24%)
		Periplasmic_Binding_Protein_Type_2	<496..637	CDD:328725	33/140 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462833
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840