DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIE and clumsy

DIOPT Version :9

Sequence 1:	NP_001036733.1	Gene:	GluRIIE / 318623	FlyBaseID:	FBgn0051201	Length:	897	Species:	Drosophila melanogaster
Sequence 2:	NP_001036373.1	Gene:	clumsy / 35394	FlyBaseID:	FBgn0026255	Length:	1002	Species:	Drosophila melanogaster

Alignment Length:	939	Identity:	318/939 - (33%)
Similarity:	484/939 - (51%)	Gaps:	103/939 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MFFNHFVILWSLFSIHISVNWAQYENFGGYDNYQSLESVPIGLLTDQNTEQMNIVFDHAIDVAN- 64
            :|..||:::  ...:...::.:|:               .:|.:...:.::..|.|..|:|.||
  Fly     4 LFLTHFLLI--ALPVLADIDRSQF---------------MVGSIFTSDKDESEIAFRTAVDRANI 51

  Fly    65 QEVGTSLTSLKEEVNYGDAYQSYGKLCRMLETGIAGVFGPSSRHTAVHLMSICDAMDIPHI-YSY 128
            .|....|..:....|..|::.....:|.::..|:..:||||:..::..:.||||.:||||| |.:
  Fly    52 LERNVELVPIVVYANTDDSFIMEKMVCNLISQGVIAIFGPSTGSSSDIIASICDTLDIPHIVYDW 116

  Fly   129 M--------SENAEGFNLHPHPADLAKALYSLITEFNWTRFIFLYESAEYLNILNELTTMLGKSG 185
            :        ..:....|:||....|::.|..::..|.|..|..:||:.:.|..|.:: ..:|:..
  Fly   117 IPNESIPDREHSTMTLNVHPDNLLLSQGLAEIVQSFAWRSFTVVYETDKELQQLQDI-LQVGEPI 180

  Fly   186 TVITVLRYDMQL--NGNYKQVLRRVRKSVDNRIVVVGSSETMPEFLNQAQQVGIINEDYKYIIGN 248
            :..|.::   ||  ..:::..|:.::.|.||.:::..:.:.:.:.|.||.::.::.|.....|..
  Fly   181 SNPTTVK---QLGPGDDHRPFLKEIKLSTDNCLILHCAPDNLLKILQQANELKMLGEYQSVFIPL 242

  Fly   249 LDFHSFDLEEYKYSEANITGLRLFSPEKMAVKELLMKLGYPTDQDEFRNGSC------PITVEMA 307
            ||.||.|..|....|||||.:||..|....||.::    :..::.|.|.|..      .:..:|.
  Fly   243 LDTHSIDFGELSGVEANITTVRLMDPSDFHVKNVV----HDWEEREKREGRYFKVDPNRVKSQMI 303

  Fly   308 LTYDAVQLFAQTLKNLPF--------------KPMPQNCSQRTESVRDDGSSFKNYMRTLRLTDR 358
            |..|||.||::.|..|..              ||.|            .|.....:::.  .::.
  Fly   304 LLNDAVWLFSKGLTELGIFEELTAPDLECRRKKPWP------------FGKRIIEFIKA--RSEE 354

  Fly   359 LLTGPIYF-EGNVRKGYHLDVIELQPSGIVKVGTWD--------EDRQYRPQRLAPTTAQFDSVD 414
            ..||.|.| |...|..:.|..:||...|.:.:.|||        .|.:...:|          |.
  Fly   355 TSTGRIDFNENGQRSFFTLRFMELNSDGFLDLATWDPVNGLDVLNDDEESEKR----------VG 409

  Fly   415 NSLANKTFIILLSVPNKPYAQLVETYKQ--LEGNSQYEGYGVDLIKELADKLGFNFTF-VNGGND 476
            ..|:|||||: .|....|:..|.|..:.  |.|||:||||.:|||.|:|..|.|.|.| ::....
  Fly   410 QKLSNKTFIV-SSRLGAPFLTLREPQEGEILTGNSRYEGYSIDLINEIAKMLNFKFEFRMSPDGK 473

  Fly   477 YGSYNKSTNESTGMLREIMTGRADLAITDLTITSEREQALDFTIPFMNLGIAILYLKPQKATPEL 541
            ||:.||.|....|::|:::.|.|||.|.|||:||.|.||:|||.|||.|||:||:.||.....:|
  Fly   474 YGALNKVTQTWDGIVRQLIDGNADLGICDLTMTSSRRQAVDFTPPFMTLGISILFSKPPTPPTDL 538

  Fly   542 FTFMDPFSEEVWWFLGFSFLGVSLSFFILGRLSPSEWDNPYPCIEEPEELENQFTLGNSIWFTTG 606
            |:|:.|||.:||.::|.::|.:||..|.|.|::|.:|:||:|| :||||:||.:::.|:.|.:.|
  Fly   539 FSFLSPFSLDVWIYMGSAYLFISLLLFALARMAPDDWENPHPC-KEPEEVENIWSIMNTTWLSIG 602

  Fly   607 ALLQQGSEIGPKALSTRTVASFWWFFTLIVVSSYTANLAAFLTIEKPQSLINSVDDLADNKDGVV 671
            :|:.||.:|.|||.|||.|...||||.|::::|||||||||||..:..:.|||.:||| .:..:.
  Fly   603 SLMGQGCDILPKAASTRLVTGMWWFFALMMLNSYTANLAAFLTNSRQANSINSAEDLA-AQSKIK 666

  Fly   672 YGAKKTGSTRNFFMTSAEERYKKMNKFM-SENPQYLTEDNMEGVNRV-KTNTHYAFLMESTSIEY 734
            |||...|||..||..|....|:||...| |.:|...|:.|.|||.|| |....||||||||::||
  Fly   667 YGAMAGGSTMGFFRDSNFSTYQKMWTAMESASPSVFTKTNDEGVERVQKGKNLYAFLMESTTLEY 731

  Fly   735 NTKRECNLKKIGDALDEKGYGIAMRKDWPHRGKFNNALLELQEQGVLEKMKNKWWNEV-GTGIC- 797
            |.:|:|:|.:||..||.|.|||||..:.|:|.:.:.|:|:|.|.|.|.::|.|||.|: |.|.|
  Fly   732 NVERKCDLVQIGGWLDYKSYGIAMPFNSPYRKQISAAVLKLGELGQLAELKRKWWKEMHGGGNCE 796

  Fly   798 ATKEDAPDATPLDMNNLEGVFFVLLVGSCCALLYGIISWVLFVMKKAHHYRVPLRDALKEEFQFV 862
            .:.||..|...|.:.|:.|||.||.:|...|::.|...::..|...|...::.|::|.|.|..|.
  Fly   797 KSDEDGGDTPELGLENVGGVFLVLGLGLLSAMVLGCTEFLWNVKSVAIEEKISLKEAFKSEALFA 861

  Fly   863 IDF---NNYVRVLKNSASIYSRSRQSSMS 888
            ...   ...|.....|.|..|.|..||.|
  Fly   862 ARIWITTKPVHTSSESGSSNSSSSSSSRS 890

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIE	NP_001036733.1	PBP1_iGluR_Kainate	42..396	CDD:107377	97/394 (25%)
		ANF_receptor	51..382	CDD:279440	91/363 (25%)
		PBP2_iGluR_Kainate	419..790	CDD:270432	180/375 (48%)
		Lig_chan	551..824	CDD:278489	130/276 (47%)
clumsy	NP_001036373.1	PBP1_iGluR_Kainate	26..396	CDD:107377	97/391 (25%)
		ANF_receptor	39..379	CDD:279440	91/361 (25%)
		PBP2_iGluR_Kainate	414..787	CDD:270432	180/375 (48%)
		Lig_chan	548..812	CDD:278489	124/265 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462602
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D17567at33392
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm1027
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	P	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	9	8.750