Protein Alignment GluRIIE and GluRIIB

DIOPT Version :10

• Sequence 1: NP_001036733.1
• Gene: GluRIIE / 318623
• FlyBaseID: FBgn0051201
• Length: 897
• Species: Drosophila melanogaster
• Sequence 2: NP_523485.3
• Gene: GluRIIB / 33789
• FlyBaseID: FBgn0020429
• Length: 913
• Species: Drosophila melanogaster
• Alignment Length: 905
• Identity: 255/905 - (28%)
• Similarity: 429/905 - (47%)
• Gaps: 103/905 - (11%)

  Fly    54 IVFD------HAIDVANQEVGT-----SLTSLKEEVNYGDAYQSYGKLCRMLETGIAGVFGPSSR 107
            |.||      .|...|.:||..     .|.::|..|...|:.......|.::.:|:|.:|||||:
  Fly    30 IFFDTEMKLADAFSAALEEVNAINPALKLDAIKRYVTVDDSIVLQDISCDLIGSGVAAIFGPSSK 94

  Fly   108 HTAVHLMSICDAMDIPHI---YSYMSENAEGF------NLHPHPADLAKALYSLITE--FNWTRF 161
            ..:..:..:|:...|||:   :.....|.|..      |:.|....|:.|...::..  |:|..|
  Fly    95 TNSDIVEVLCNMTGIPHLQFDWHPQQSNRERMNHQLTVNVAPMELFLSAAFSDILASKTFDWKSF 159

  Fly   162 IFLYESAEYLNILNELTT--MLGKSGTVITVLRYDMQLNGNYKQVLRRVRKSVDNRIVVVGSSET 224
            ...||.:.:|..|..:..  .|.|:|    :...:.:...:|:.:.:|:..:.:..:::...|:.
  Fly   160 TIAYERSSHLIRLQHILAWKQLHKAG----IKMQEFERGDDYRILWKRINNAREKFVLLDCPSDI 220

  Fly   225 MPEFLNQAQQVGIINEDYKYIIGNLDFHSFDLEEYKYSEANITGLRLFSPEKMAVKELLMKLGYP 289
            :.:.:|.:....:........:.|||.|...::.: ||       |.|:   :||..:.::...|
  Fly   221 LVDVINASIGYNMTGSFNHLFLTNLDTHLSGIDGF-YS-------RDFT---VAVAAVRIRTYVP 274

  Fly   290 ----TDQDEFRN---------GSCPITVEMALTYDAVQLFAQTLKNLPFKP---MPQ-NCSQRTE 337
                .:.|.|.|         ||       .|.||::.||...|..:..:|   :|. :|.:
  Fly   275 PPVHDEIDVFDNSVDTRFSSLGS-------QLVYDSIVLFYNALLEISQRPGFYIPNFSCGR--- 329

  Fly   338 SVRDDGSSFKNYMRTLRLTDRLLTGP-------IYFEGNVRKGYHLDVIELQPSGIVKVGTWDED 395
            .....|......|:  ::|.:::..|       |..:|. |:.::|:|.......:..:  |:::
  Fly   330 GFWQPGPRLVEQMK--QITPKMVKPPFKTQRLQINADGQ-REDFNLEVYNPIIDRVTHI--WNKE 389

  Fly   396 ---------RQYRPQRLAPTTAQFDSVDNSLANKTFIILLSVPNKPYAQLVETYK--QLEGNSQY 449
                     |:...|.|.....| :..|.|.....:.:...| .|||....|..:  ..|||.::
  Fly   390 FQLVDFEKLRENSTQALKQKRLQ-NKEDFSQKPIRYTVATRV-GKPYFSWREEPEGVHYEGNERF 452

  Fly   450 EGYGVDLIKELADKLGFNFTFVN-GGNDYGSYNKSTNESTGMLREIMTGRADLAITDLTITSERE 513
            |||.||||..||.:..|:|.|.. ..|.||||:.:|:|..|::|:::...|.:.|.|||||..|.
  Fly   453 EGYAVDLIYMLAQECKFDFNFEPVRDNKYGSYDANTDEWDGIIRQLIDNNAQIGICDLTITQARR 517

  Fly   514 QALDFTIPFMNLGIAILYLKPQKATPELFTFMDPFSEEVWWFLGFSFLGVSLSFFILGRLSPSEW 578
            ..:|||:|||.|||:||..|......:::.|::|::.|||.|:..:.:..:.:....||:...||
  Fly   518 SVVDFTVPFMQLGISILSYKEPPPKADIYAFLNPYNAEVWLFVMIAMMITAFALIFTGRIDQYEW 582

  Fly   579 DNPYPCIEEPEELENQFTLGNSIWFTTGALLQQGSEIGPKALSTRTVASFWWFFTLIVVSSYTAN 643
            |.|...:....|.:|.:.|.|::|...|::|.||.::.|:.|..|.:.:|||.|.|::..:|.|.
  Fly   583 DQPVENVNREMERQNIWHLSNALWLVLGSMLNQGCDLLPRGLPMRLLTAFWWIFALLISQTYIAK 647

  Fly   644 LAAFLTIEKPQSLINSVDDLAD-NKDGVVYGAKKTGSTRNFFMTSAE-ERYKKMNKFMSENPQYL 706
            ||||:|..|....|.|:.||.| ||  |.:|..:.|:|..:|..|.: :.....||.:|..|...
  Fly   648 LAAFITSSKIAGDIGSLHDLVDQNK--VQFGTIRGGATSVYFSESNDTDNRMAWNKMLSFKPDAF 710

  Fly   707 TEDNMEGVNRVK-TNTHYAFLMESTSIEYNTKRECNLKKIGDALDEKGYGIAMRKDWPHRGKFNN 770
            |::|.|||:||| :...||||||:|:::|..:|.|.|.:||::..||.||||:..:...|...:.
  Fly   711 TKNNEEGVDRVKLSKGTYAFLMETTNLQYYVQRNCELTQIGESFGEKHYGIAVPLNADFRSNLSV 775

  Fly   771 ALLELQEQGVLEKMKNKWWNEVGTGICATKEDAPDATPLDMNNLEGVFFVLLVGSCCALLYGIIS 835
            .:|.|.|:|.|.|::|||:|. ....|.:.....|....||:::.|:|.||:||....|:.|:..
  Fly   776 GILRLSERGELFKLRNKWFNS-NESTCDSNVPTIDDGQFDMDSVGGLFVVLIVGVVVGLVIGVAE 839

  Fly   836 WVLFVMKKAHHYRVPLRDALKEEFQFVIDFNNYVRVLKNSASIYSRSRQS-SMSVASVAQ 894
            ::..|.:.:...::|...|||.||.|||.|    .:.:.....|.:||.| |...:|:.|
  Fly   840 FLWHVQRISVKEKIPPMLALKAEFYFVIRF----WLTRKPLHTYRQSRDSTSTGYSSLEQ 895

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIE	NP_001036733.1	PBP1_iGluR_Kainate	40..402	CDD:380605	79/404 (20%)
		PBP2_iGluR_Kainate	419..790	CDD:270432	140/376 (37%)
		Lig_chan	551..824	CDD:459656	98/275 (36%)
GluRIIB	NP_523485.3	PBP1_iGluR_Kainate	26..387	CDD:380605	77/386 (20%)
		PBP2_iGluR_Kainate	422..795	CDD:270432	140/375 (37%)