DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIE and GluRIIB

DIOPT Version :9

Sequence 1:	NP_001036733.1	Gene:	GluRIIE / 318623	FlyBaseID:	FBgn0051201	Length:	897	Species:	Drosophila melanogaster
Sequence 2:	NP_523485.3	Gene:	GluRIIB / 33789	FlyBaseID:	FBgn0020429	Length:	913	Species:	Drosophila melanogaster

Alignment Length:	905	Identity:	255/905 - (28%)
Similarity:	429/905 - (47%)	Gaps:	103/905 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 IVFD------HAIDVANQEVGT-----SLTSLKEEVNYGDAYQSYGKLCRMLETGIAGVFGPSSR 107
            |.||      .|...|.:||..     .|.::|..|...|:.......|.::.:|:|.:|||||:
  Fly    30 IFFDTEMKLADAFSAALEEVNAINPALKLDAIKRYVTVDDSIVLQDISCDLIGSGVAAIFGPSSK 94

  Fly   108 HTAVHLMSICDAMDIPHI---YSYMSENAEGF------NLHPHPADLAKALYSLITE--FNWTRF 161
            ..:..:..:|:...|||:   :.....|.|..      |:.|....|:.|...::..  |:|..|
  Fly    95 TNSDIVEVLCNMTGIPHLQFDWHPQQSNRERMNHQLTVNVAPMELFLSAAFSDILASKTFDWKSF 159

  Fly   162 IFLYESAEYLNILNELTT--MLGKSGTVITVLRYDMQLNGNYKQVLRRVRKSVDNRIVVVGSSET 224
            ...||.:.:|..|..:..  .|.|:|    :...:.:...:|:.:.:|:..:.:..:::...|:.
  Fly   160 TIAYERSSHLIRLQHILAWKQLHKAG----IKMQEFERGDDYRILWKRINNAREKFVLLDCPSDI 220

  Fly   225 MPEFLNQAQQVGIINEDYKYIIGNLDFHSFDLEEYKYSEANITGLRLFSPEKMAVKELLMKLGYP 289
            :.:.:|.:....:........:.|||.|...::.: ||       |.|:   :||..:.::...|
  Fly   221 LVDVINASIGYNMTGSFNHLFLTNLDTHLSGIDGF-YS-------RDFT---VAVAAVRIRTYVP 274

  Fly   290 ----TDQDEFRN---------GSCPITVEMALTYDAVQLFAQTLKNLPFKP---MPQ-NCSQRTE 337
                .:.|.|.|         ||       .|.||::.||...|..:..:|   :|. :|.:
  Fly   275 PPVHDEIDVFDNSVDTRFSSLGS-------QLVYDSIVLFYNALLEISQRPGFYIPNFSCGR--- 329

  Fly   338 SVRDDGSSFKNYMRTLRLTDRLLTGP-------IYFEGNVRKGYHLDVIELQPSGIVKVGTWDED 395
            .....|......|:  ::|.:::..|       |..:|. |:.::|:|.......:..:  |:::
  Fly   330 GFWQPGPRLVEQMK--QITPKMVKPPFKTQRLQINADGQ-REDFNLEVYNPIIDRVTHI--WNKE 389

  Fly   396 ---------RQYRPQRLAPTTAQFDSVDNSLANKTFIILLSVPNKPYAQLVETYK--QLEGNSQY 449
                     |:...|.|.....| :..|.|.....:.:...| .|||....|..:  ..|||.::
  Fly   390 FQLVDFEKLRENSTQALKQKRLQ-NKEDFSQKPIRYTVATRV-GKPYFSWREEPEGVHYEGNERF 452

  Fly   450 EGYGVDLIKELADKLGFNFTFVN-GGNDYGSYNKSTNESTGMLREIMTGRADLAITDLTITSERE 513
            |||.||||..||.:..|:|.|.. ..|.||||:.:|:|..|::|:::...|.:.|.|||||..|.
  Fly   453 EGYAVDLIYMLAQECKFDFNFEPVRDNKYGSYDANTDEWDGIIRQLIDNNAQIGICDLTITQARR 517

  Fly   514 QALDFTIPFMNLGIAILYLKPQKATPELFTFMDPFSEEVWWFLGFSFLGVSLSFFILGRLSPSEW 578
            ..:|||:|||.|||:||..|......:::.|::|::.|||.|:..:.:..:.:....||:...||
  Fly   518 SVVDFTVPFMQLGISILSYKEPPPKADIYAFLNPYNAEVWLFVMIAMMITAFALIFTGRIDQYEW 582

  Fly   579 DNPYPCIEEPEELENQFTLGNSIWFTTGALLQQGSEIGPKALSTRTVASFWWFFTLIVVSSYTAN 643
            |.|...:....|.:|.:.|.|::|...|::|.||.::.|:.|..|.:.:|||.|.|::..:|.|.
  Fly   583 DQPVENVNREMERQNIWHLSNALWLVLGSMLNQGCDLLPRGLPMRLLTAFWWIFALLISQTYIAK 647

  Fly   644 LAAFLTIEKPQSLINSVDDLAD-NKDGVVYGAKKTGSTRNFFMTSAE-ERYKKMNKFMSENPQYL 706
            ||||:|..|....|.|:.||.| ||  |.:|..:.|:|..:|..|.: :.....||.:|..|...
  Fly   648 LAAFITSSKIAGDIGSLHDLVDQNK--VQFGTIRGGATSVYFSESNDTDNRMAWNKMLSFKPDAF 710

  Fly   707 TEDNMEGVNRVK-TNTHYAFLMESTSIEYNTKRECNLKKIGDALDEKGYGIAMRKDWPHRGKFNN 770
            |::|.|||:||| :...||||||:|:::|..:|.|.|.:||::..||.||||:..:...|...:.
  Fly   711 TKNNEEGVDRVKLSKGTYAFLMETTNLQYYVQRNCELTQIGESFGEKHYGIAVPLNADFRSNLSV 775

  Fly   771 ALLELQEQGVLEKMKNKWWNEVGTGICATKEDAPDATPLDMNNLEGVFFVLLVGSCCALLYGIIS 835
            .:|.|.|:|.|.|::|||:|. ....|.:.....|....||:::.|:|.||:||....|:.|:..
  Fly   776 GILRLSERGELFKLRNKWFNS-NESTCDSNVPTIDDGQFDMDSVGGLFVVLIVGVVVGLVIGVAE 839

  Fly   836 WVLFVMKKAHHYRVPLRDALKEEFQFVIDFNNYVRVLKNSASIYSRSRQS-SMSVASVAQ 894
            ::..|.:.:...::|...|||.||.|||.|    .:.:.....|.:||.| |...:|:.|
  Fly   840 FLWHVQRISVKEKIPPMLALKAEFYFVIRF----WLTRKPLHTYRQSRDSTSTGYSSLEQ 895

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIE	NP_001036733.1	PBP1_iGluR_Kainate	42..396	CDD:107377	78/398 (20%)
		ANF_receptor	51..382	CDD:279440	77/375 (21%)
		PBP2_iGluR_Kainate	419..790	CDD:270432	140/376 (37%)
		Lig_chan	551..824	CDD:278489	98/275 (36%)
GluRIIB	NP_523485.3	PBP1_iGluR_Kainate	26..393	CDD:107377	78/392 (20%)
		ANF_receptor	41..378	CDD:279440	74/364 (20%)
		PBP2_iGluR_Kainate	422..795	CDD:270432	140/375 (37%)
		Lig_chan	555..822	CDD:278489	95/269 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462596
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	137	1.000	Inparanoid score	I1813
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D17567at33392
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	8	7.900