Protein Alignment GluRIIE and Ir25a

DIOPT Version :9

• Sequence 1: NP_001036733.1
• Gene: GluRIIE / 318623
• FlyBaseID: FBgn0051201
• Length: 897
• Species: Drosophila melanogaster
• Sequence 2: NP_001260049.1
• Gene: Ir25a / 33683
• FlyBaseID: FBgn0031634
• Length: 947
• Species: Drosophila melanogaster
• Alignment Length: 982
• Identity: 230/982 - (23%)
• Similarity: 392/982 - (39%)
• Gaps: 275/982 - (28%)

  Fly     6 FVILWSLFSIHISVNWAQYENFGGYDNYQSLESVPIGLLTDQNTEQMNIVFDHAID--VANQEVG 68
            |:.|.|.||:.|:.                           |.|:.:|::|.:.:|  .|.:.|.
  Fly    17 FLSLLSSFSLEIAA---------------------------QTTQNINVLFINEVDNEPAAKAVE 54

  Fly    69 TSLTSLKEEVNYG-----DAYQSYGKLCRMLETGIAGVFGPS-SRHTAVHLM------------- 114
            ..||.||:.:.||     |:.::.....::|...|...:..| .:....||:
  Fly    55 VVLTYLKKNIRYGLSVQLDSIEANKSDAKVLLEAICNKYATSIEKKQTPHLILDTTKSGIASETV 119

  Fly   115 -SICDAMDIPHI-YSY-----------MSENAEGFNLH--PHPAD-LAKALYSLITEFNWTRFIF 163
             |...|:.:|.| .||           :.|..:.:.|.  | ||| :.:|:.|::...|.|....
  Fly   120 KSFTQALGLPTISASYGQQGDLRQWRDLDEAKQKYLLQVMP-PADIIPEAIRSIVIHMNITNAAI 183

  Fly   164 LYESA-----EYLNILNELTTMLGKSGTVITVLRYDMQLNGNYKQVLRRVRKSVDNRIVVVGSSE 223
            ||:.:     :|.::|..:.|.     .|||.:..|.:  ...::.:.::|....|...::|:
  Fly   184 LYDDSFVMDHKYKSLLQNIQTR-----HVITAIAKDGK--REREEQIEKLRNLDINNFFILGT-- 239

  Fly   224 TMPEFLNQAQQVGIINEDYK--YIIGNLDFHSFDLEEYKYSEA--NIT----------------- 267
                    .|.:.::.|..|  |...|..:|:....|.:.|..  |.|
  Fly   240 --------LQSIRMVLESVKPAYFERNFAWHAITQNEGEISSQRDNATIMFMKPMAYTQYRDRLG 296

  Fly   268 ----------------------GLRLFSPEKMAVKELLMKLGYPTDQ-----DEFRNGSCPITVE 305
                                  .||.|    :.:||:|....:|.|.     |:|:.|:.|
  Fly   297 LLRTTYNLNEEPQLSSAFYFDLALRSF----LTIKEMLQSGAWPKDMEYLNCDDFQGGNTP---- 353

  Fly   306 MALTYDAVQLFAQTLKNLPFKPMPQNCSQRTESVRD------DGSSFKNYMRTLRLTDRLLTGPI 364
                                        ||...:||      :.:|:..:       |.:.....
  Fly   354 ----------------------------QRNLDLRDYFTKITEPTSYGTF-------DLVTQSTQ 383

  Fly   365 YFEGNVRKGYHLDVIELQPSG-----IVKVGTW-----------DEDRQYRPQRLAPTTAQFDSV 413
            .|.|:....:.:|:..||..|     ...:|.|           ||::.
  Fly   384 PFNGHSFMKFEMDINVLQIRGGSSVNSKSIGKWISGLNSELIVKDEEQM---------------- 432

  Fly   414 DNSLANKTFIILLSVPNKPYAQLVETYKQLEGNSQYEGYGVDLIKELADKLGFNFTF--VNGGND 476
             .:|...|...:.:|...|:....||     ....|:||.:|||.|:|..:.|::|.  |..|.
  Fly   433 -KNLTADTVYRIFTVVQAPFIMRDET-----APKGYKGYCIDLINEIAAIVHFDYTIQEVEDGK- 490

  Fly   477 YGSYNKSTNESTGMLREIMTGRADLAITDLTITSEREQALDFTIPFMNL-GIAILYLKPQKATPE 540
            :|:.::: .:..|:::::|..:||:.:..:::.:|||..:|||:|:.:| ||.|:..:|...: .
  Fly   491 FGNMDEN-GQWNGIVKKLMDKQADIGLGSMSVMAEREIVIDFTVPYYDLVGITIMMQRPSSPS-S 553

  Fly   541 LFTFMDPFSEEVWWFLGFSFLGVSLSFFILGRLSPSEWDNPYPCIEEPEELENQFTLGNSIWFTT 605
            ||.|:......||..:..::...|...:|..|.||..:.|.....::.|| :.:|.|...:||..
  Fly   554 LFKFLTVLETNVWLCILAAYFFTSFLMWIFDRWSPYSYQNNREKYKDDEE-KREFNLKECLWFCM 617

  Fly   606 GALLQQGSEIGPKALSTRTVASFWWFFTLIVVSSYTANLAAFLTIEKPQSLINSVDDLADNKDGV 670
            .:|..||....||.||.|.||:.||.|..|:::|||||||||||:.:..:.:.|:|||| .:..:
  Fly   618 TSLTPQGGGEAPKNLSGRLVAATWWLFGFIIIASYTANLAAFLTVSRLDTPVESLDDLA-KQYKI 681

  Fly   671 VYGAKKTGSTRNFF----------------------MTSAE------------ERYKKMNKFMSE 701
            :|......|...:|                      :|:.|            ::|.||.:.|.|
  Fly   682 LYAPLNGSSAMTYFERMSNIEQMFYEIWKDLSLNDSLTAVERSKLAVWDYPVSDKYTKMWQAMQE 746

  Fly   702 NPQYLTEDNMEGVNRVKTN---THYAFLMESTSIEYNTKRECNLKKIGDALDEKGYGIAMRKDWP 763
            .....|.|  |.|.||:.:   |.:|||.::|.|.|.....|:|:.:|:....|.|.||:::...
  Fly   747 AKLPATLD--EAVARVRNSTAATGFAFLGDATDIRYLQLTNCDLQVVGEEFSRKPYAIAVQQGSH 809

  Fly   764 HRGKFNNALLELQEQGVLEKMKNKWW-NEVGTGICATKEDAPDATPLDMNNLEGVFFVLLVG--- 824
            .:.:||||:|.|..:..|||:|.||| |:.....|...||..|.  :.:.|:.|||.|:.||
  Fly   810 LKDQFNNAILTLLNKRQLEKLKEKWWKNDEALAKCDKPEDQSDG--ISIQNIGGVFIVIFVGIGM 872

  Fly   825 SCCALLY 831
            :|..|::
  Fly   873 ACITLVF 879

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIE	NP_001036733.1	PBP1_iGluR_Kainate	42..396	CDD:107377	85/465 (18%)
		ANF_receptor	51..382	CDD:279440	76/426 (18%)
		PBP2_iGluR_Kainate	419..790	CDD:270432	124/411 (30%)
		Lig_chan	551..824	CDD:278489	97/310 (31%)
Ir25a	NP_001260049.1	PBP1_iGluR_AMPA_Like	40..426	CDD:107378	80/446 (18%)
		PBP2_iGluR_putative	438..836	CDD:270435	123/409 (30%)
		Lig_chan	565..870	CDD:278489	98/310 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462881
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm1027
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.840