Protein Alignment GluRIIE and gria4b

DIOPT Version :10

• Sequence 1: NP_001036733.1
• Gene: GluRIIE / 318623
• FlyBaseID: FBgn0051201
• Length: 897
• Species: Drosophila melanogaster
• Sequence 2: NP_997917.2
• Gene: gria4b / 336069
• ZFINID: ZDB-GENE-030131-8013
• Length: 904
• Species: Danio rerio
• Alignment Length: 860
• Identity: 296/860 - (34%)
• Similarity: 463/860 - (53%)
• Gaps: 54/860 - (6%)

  Fly    38 SVPIGLLTDQNTEQMNIVFDHAIDVAN-----QEVGTSLTSLKEEVNYGDAYQSYGKLCRMLETG 97
            ||.||.|..:||:|....|..||.:.|     .|...:|....:.:...:::......|.....|
Zfish    26 SVQIGGLFIRNTDQEYTAFRLAIFLHNTSPNASEAPFNLVPHVDNIETANSFAVTNAFCSQYSRG 90

  Fly    98 IAGVFGPSSRHTAVHLMSICDAMDIPHIY-SYMSENAEGFNLHPHPADLAKALYSLITEFNWTRF 161
            :..:||...:.:...|.|.|.|:.|..|. |:.:|....|.|...|: :..||.||:..::|.||
Zfish    91 VFAIFGLYDKRSVHTLTSFCGALHISLITPSFPTEGESQFVLQLRPS-IRGALLSLLDHYDWNRF 154

  Fly   162 IFLYESAEYLNILNELTTMLGKSGTVITVLRYDMQLNGNYKQVLRRVRKSVDNRIVVVGSSETMP 226
            :|||::....:||..:....|::|..::.:..:...:.:|:|:|..:.:..:...|:...:|.:.
Zfish   155 VFLYDTDRGYSILQAIMEKAGQNGWQVSAICVENFNDASYRQLLEDLDRRQEKTFVIDLEAERLN 219

  Fly   227 EFLNQAQQVGIINEDYKYIIGNLDFHSFDLEEYKYSEANITGLRL--FSPEKMAVKELLMKLGYP 289
            ..|.|...||...:.|.||:.||.|...:||.:.:..||:||.:|  || ..|.:|  ||:....
Zfish   220 NMLEQIVSVGKHVKGYHYIMANLGFKDINLERFMHGGANVTGFQLVDFS-NPMVIK--LMQRWNK 281

  Fly   290 TDQDEFRNGSCPITVEMALTYDAVQLFAQTLKNL-------PFKPMPQNCSQRTESVRDDGSSFK 347
            .||.|:.....|.....|||||.|.:.|:..:||       ..:.:..:|.....:..:.|...:
Zfish   282 LDQREYPGSDAPPKYTSALTYDGVMVMAEAFRNLRRQKVDISRRGIAGDCLANPAAPWNQGIDME 346

  Fly   348 NYMRTLRLTDRLLTGPIYFEGNVRK-GYHLDVIELQPSGIVKVGTW-DEDRQYRPQRLAPTTAQF 410
            ..::.:.|..  |||.:.|:...|: .|.:||.||:.:|..::|.| |.|:..    |....|..
Zfish   347 RTLKQVHLQG--LTGNVQFDHYGRRVNYTMDVFELKSNGPRRIGYWNDADKLV----LTQDHALL 405

  Fly   411 DSVDNSLANKTFIILLSVPNKPYAQLVETYKQLEGNSQYEGYGVDLIKELADKLGFNF--TFVNG 473
            .:..:.:.|:| :|:.::...||..|.:.::..|||.|||||.|||..|:|..:||.:  :.|..
Zfish   406 PNETSGMENRT-VIVTTIMEGPYVMLKKNWEMYEGNEQYEGYCVDLASEIAKHIGFKYKISIVPD 469

  Fly   474 GNDYGSYNKSTNESTGMLREIMTGRADLAITDLTITSEREQALDFTIPFMNLGIAILYLKPQKAT 538
            |. ||:.:..|....||:.|::.|:|::|:..||||..||:.:||:.|||:|||:|:..||||:.
Zfish   470 GK-YGARDPETKIWNGMVGELVYGKAEIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSK 533

  Fly   539 PELFTFMDPFSEEVWWFLGFSFLGVSLSFFILGRLSPSEWDNPYPCIEEPEE---------LENQ 594
            |.:|:|:||.:.|:|..:.|:::|||:..|::.|.||.||..     |||||         ..|:
Zfish   534 PGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHT-----EEPEEGTDGLPSDQPPNE 593

  Fly   595 FTLGNSIWFTTGALLQQGSEIGPKALSTRTVASFWWFFTLIVVSSYTANLAAFLTIEKPQSLINS 659
            |.:.||:||:.||.:|||.:|.|::||.|.|...|||||||::||||||||||||:|:..|.|.|
Zfish   594 FGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIES 658

  Fly   660 VDDLADNKDGVVYGAKKTGSTRNFFMTSAEERYKKMNKFM-SENPQYLTEDNMEGVNRV-KTNTH 722
            .:|||...| :.||...:|||:.||..|....|:||..:| |..|...|:...|||.|| |:...
Zfish   659 AEDLAKQTD-IAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKSAEPTVFTKTTAEGVARVRKSKGK 722

  Fly   723 YAFLMESTSIEYNTKRE-CNLKKIGDALDEKGYGIAMRKDWPHRGKFNNALLELQEQGVLEKMKN 786
            ||||:|||..||..:|: |:..|:|..||.||||:|..|....|...|.|:|:|.|||:|:|:||
Zfish   723 YAFLLESTMNEYTEQRKPCDTMKVGGNLDSKGYGVATPKGSQLRSAVNLAVLKLNEQGLLDKLKN 787

  Fly   787 KWW---NEVGTGICATKEDAPDATPLDMNNLEGVFFVLLVGSCCALLYGIISWVLFVMKKAHHYR 848
            |||   .|.|:|....|:.:..|  |.::|:.|||::|:.|...|:|..:|.:......:|...:
Zfish   788 KWWYDKGECGSGGGGEKDKSSQA--LSLSNVAGVFYILVGGLGLAMLVALIEFCYKSRNEAKRMK 850

  Fly   849 VPLRDALKEEFQFVI 863
            :...:|::.:.:..|
Zfish   851 LTFTEAMRNKARLSI 865

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIE	NP_001036733.1	PBP1_iGluR_Kainate	40..402	CDD:380605	100/378 (26%)
		PBP2_iGluR_Kainate	419..790	CDD:270432	174/387 (45%)
		Lig_chan	551..824	CDD:459656	129/287 (45%)
gria4b	NP_997917.2	Periplasmic_Binding_Protein_type1	28..400	CDD:471960	101/381 (27%)
		PBP2_iGluR_AMPA_GluR4	414..793	CDD:270445	174/386 (45%)
		Lig_chan	546..826	CDD:459656	129/287 (45%)