Protein Alignment GluRIIE and GluRIIC

DIOPT Version :10

• Sequence 1: NP_001036733.1
• Gene: GluRIIE / 318623
• FlyBaseID: FBgn0051201
• Length: 897
• Species: Drosophila melanogaster
• Sequence 2: NP_608557.4
• Gene: GluRIIC / 33275
• FlyBaseID: FBgn0046113
• Length: 940
• Species: Drosophila melanogaster
• Alignment Length: 936
• Identity: 278/936 - (29%)
• Similarity: 453/936 - (48%)
• Gaps: 114/936 - (12%)

  Fly     9 LWSLFSIHISVNWAQYENFGG--YDNYQSLESVPIGLLTDQNTEQMNIVFDHAIDVANQEVGTSL 71
            :||.|  .:..:..|..|.|.  ||:...||.           |.|.:|  :||:....|.....
  Fly    11 MWSAF--FMCRSRGQQINIGAFFYDDELELEK-----------EFMTVV--NAINGPESEQTMRF 60

  Fly    72 TSLKEEVNYGD---AYQSYGKLCRMLETGIAGVFGPSSRHTAVHLMSICDAMDIPHIYSYMSENA 133
            ..|.:.:...|   ..|.:.  |.:::.|:|.:|||||:..:..:..:|::..||||...:|:
  Fly    61 YPLIKRLKPEDGSVTMQEHA--CDLIDNGVAAIFGPSSKAASDIVALVCNSTGIPHIEFDISD-- 121

  Fly   134 EG-----------FNLHPHPADLAKALYSLITEFNWTRFIFLYES--AEYLNILNELTTMLGKSG 185
            ||           .||:|..|.|:||...::..|.|.:|..:|::  |.....|.:|..:.....
  Fly   122 EGIQAEKPNHQMTLNLYPAQAILSKAYADIVQNFGWRKFTIVYDADDARAAARLQDLLQLREVHN 186

  Fly   186 TVITVLRYDMQLNGNYKQVLRRVRKSVDNRIVVVGSSETMPEFLNQAQQVGIINEDYKYIIGNLD 250
            .|:.|.::  ..:.:::.:.:.:|.  :.|:|:......:.|.||.:.:.|:..:.....:.||:
  Fly   187 DVVRVRKF--HKDDDFRVMWKSIRG--ERRVVLDCEPNMLVELLNSSTEFGLTGQYNHIFLTNLE 247

  Fly   251 FHSFDLEEYKYSE----ANITGLRLF-SPEKMAVKELLMKLGYPTDQDE--FRNGSCPITVEMAL 308
            .::..|||.....    .|||..||. :|:.....   :..||.|.:|.  :.:...|.|:...|
  Fly   248 TYTDHLEELAADNETFAVNITAARLLVNPDPPPYS---LPYGYVTQRDNIVYESSDPPRTLIHDL 309

  Fly   309 TYDAVQLFAQTLKNLPF-----KPMPQ-NCSQRTESVRDDGSSFKNYMRTLRLTDRLLTGPI--- 364
            .:||:|||||:.:|..|     ..:|: .|        |..:|........|...||:.|..
  Fly   310 IHDALQLFAQSWRNASFFYPDRMVVPRITC--------DFAASGGRTWAMGRYLARLMKGTSGVN 366

  Fly   365 ----------YFEGNVRKGYHLDVIELQPSGIVKVGTWDEDRQYRPQRLAPTTAQFDSVDNSLAN 419
                      :.|...|..::::|.:  |...:.:..||...|....          :||.....
  Fly   367 NTNFRTSILQFDEDGQRITFNIEVYD--PLDGIGIAIWDPRGQITQL----------NVDVKAQK 419

  Fly   420 KTFIILLSVPNKPYAQLVETYKQLE--GNSQYEGYGVDLIKELADKLGFNFTFVN-GGNDYGSYN 481
            |....:.:....||....||.::|.  ||:.|:||.||||..:|..:||.:.||. ....||..:
  Fly   420 KMIYRVATRIGPPYFSYNETARELNLTGNALYQGYAVDLIDAIARHVGFEYVFVPVADQQYGKLD 484

  Fly   482 KSTNESTGMLREIMTGRADLAITDLTITSEREQALDFTIPFMNLGIAILYLKPQKATPELFTFMD 546
            |.|.:..|::.||:...|.:.|.|||||..|:.|:|||:|||.||::||..|.......|..::.
  Fly   485 KETKQWNGIIGEIINNDAHMGICDLTITQARKTAVDFTVPFMQLGVSILAYKSPHVEKTLDAYLA 549

  Fly   547 PFSEEVW-WFLGFSFLGVSLSFF--ILGRLSPSEWDNPYPCIEEPEELENQFTLGNSIWFTTGAL 608
            ||..||| |.|...|:   ::|.  |:.|:|..:|:||:||..:||.||||:.:.|:.|.|..::
  Fly   550 PFGGEVWIWILISVFV---MTFLKTIVARISKMDWENPHPCNRDPEVLENQWRIHNTGWLTVASI 611

  Fly   609 LQQGSEIGPKALSTRTVASFWWFFTLIVVSSYTANLAAFLTIEKPQSLINSVDDLADNKD---GV 670
            :..|.:|.|::...|...:.||.|.:|:.:|||||||||||..|.:..|.::.||:..|.   |.
  Fly   612 MTAGCDILPRSPQVRMFEATWWIFAIIIANSYTANLAAFLTSSKMEGSIANLKDLSAQKKVKFGT 676

  Fly   671 VYGAKKTGSTRNFFMTSAEERYK-KMNKFMSENPQYLTEDNMEGVNRVKTNT-HYAFLMESTSIE 733
            :||    |||.|....|.|..|: ..|...:::|...|:||:|||:||:.|. .|.||||:|::|
  Fly   677 IYG----GSTYNLLADSNETVYRLAFNLMNNDDPSAYTKDNLEGVDRVRKNRGDYMFLMETTTLE 737

  Fly   734 YNTKRECNLKKIGDALDEKGYGIAMRKDWPHRGKFNNALLELQEQGVLEKMKNKWWNEVGTGICA 798
            |:.::.|:|:.:|:...||.|.||:.....:|...:.|:|:|.|:|.|..:|.|||...... |.
  Fly   738 YHREQNCDLRSVGEKFGEKHYAIAVPFGAEYRSNLSVAILKLSERGELYDLKQKWWKNPNAS-CF 801

  Fly   799 TKEDAPDATP-LDMNNLEGVFFVLLVGSCCALLYGIISWVLFVMKKAHHYRVPLRDALKEEFQFV 862
            .:.| ||||| :....|.|:|:.|..|...|.|.||..::::|.:.|...|:..:||.|:|.:||
  Fly   802 EEPD-PDATPDMTFEELRGIFYTLYAGILIAFLIGITEFLVYVQQVALEERLTFKDAFKKEIRFV 865

  Fly   863 I-DFNNYVRVLKNS--ASIYSRSRQS 885
            : .:||...::..:  :|:.:..|:|
  Fly   866 LCVWNNRKPIVAGTPISSVRTTPRRS 891

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIE	NP_001036733.1	PBP1_iGluR_Kainate	40..402	CDD:380605	90/403 (22%)
		PBP2_iGluR_Kainate	419..790	CDD:270432	145/381 (38%)
		Lig_chan	551..824	CDD:459656	107/281 (38%)
GluRIIC	NP_608557.4	Periplasmic_Binding_Protein_type1	26..409	CDD:471960	96/416 (23%)
		PBP2_iGluR_Kainate	423..794	CDD:270432	144/377 (38%)
		Lig_chan	554..827	CDD:459656	107/281 (38%)