DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIE and GluRIIC

DIOPT Version :9

Sequence 1:	NP_001036733.1	Gene:	GluRIIE / 318623	FlyBaseID:	FBgn0051201	Length:	897	Species:	Drosophila melanogaster
Sequence 2:	NP_608557.4	Gene:	GluRIIC / 33275	FlyBaseID:	FBgn0046113	Length:	940	Species:	Drosophila melanogaster

Alignment Length:	936	Identity:	278/936 - (29%)
Similarity:	453/936 - (48%)	Gaps:	114/936 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LWSLFSIHISVNWAQYENFGG--YDNYQSLESVPIGLLTDQNTEQMNIVFDHAIDVANQEVGTSL 71
            :||.|  .:..:..|..|.|.  ||:...||.           |.|.:|  :||:....|.....
  Fly    11 MWSAF--FMCRSRGQQINIGAFFYDDELELEK-----------EFMTVV--NAINGPESEQTMRF 60

  Fly    72 TSLKEEVNYGD---AYQSYGKLCRMLETGIAGVFGPSSRHTAVHLMSICDAMDIPHIYSYMSENA 133
            ..|.:.:...|   ..|.:.  |.:::.|:|.:|||||:..:..:..:|::..||||...:|:
  Fly    61 YPLIKRLKPEDGSVTMQEHA--CDLIDNGVAAIFGPSSKAASDIVALVCNSTGIPHIEFDISD-- 121

  Fly   134 EG-----------FNLHPHPADLAKALYSLITEFNWTRFIFLYES--AEYLNILNELTTMLGKSG 185
            ||           .||:|..|.|:||...::..|.|.:|..:|::  |.....|.:|..:.....
  Fly   122 EGIQAEKPNHQMTLNLYPAQAILSKAYADIVQNFGWRKFTIVYDADDARAAARLQDLLQLREVHN 186

  Fly   186 TVITVLRYDMQLNGNYKQVLRRVRKSVDNRIVVVGSSETMPEFLNQAQQVGIINEDYKYIIGNLD 250
            .|:.|.::  ..:.:::.:.:.:|.  :.|:|:......:.|.||.:.:.|:..:.....:.||:
  Fly   187 DVVRVRKF--HKDDDFRVMWKSIRG--ERRVVLDCEPNMLVELLNSSTEFGLTGQYNHIFLTNLE 247

  Fly   251 FHSFDLEEYKYSE----ANITGLRLF-SPEKMAVKELLMKLGYPTDQDE--FRNGSCPITVEMAL 308
            .::..|||.....    .|||..||. :|:.....   :..||.|.:|.  :.:...|.|:...|
  Fly   248 TYTDHLEELAADNETFAVNITAARLLVNPDPPPYS---LPYGYVTQRDNIVYESSDPPRTLIHDL 309

  Fly   309 TYDAVQLFAQTLKNLPF-----KPMPQ-NCSQRTESVRDDGSSFKNYMRTLRLTDRLLTGPI--- 364
            .:||:|||||:.:|..|     ..:|: .|        |..:|........|...||:.|..
  Fly   310 IHDALQLFAQSWRNASFFYPDRMVVPRITC--------DFAASGGRTWAMGRYLARLMKGTSGVN 366

  Fly   365 ----------YFEGNVRKGYHLDVIELQPSGIVKVGTWDEDRQYRPQRLAPTTAQFDSVDNSLAN 419
                      :.|...|..::::|.:  |...:.:..||...|....          :||.....
  Fly   367 NTNFRTSILQFDEDGQRITFNIEVYD--PLDGIGIAIWDPRGQITQL----------NVDVKAQK 419

  Fly   420 KTFIILLSVPNKPYAQLVETYKQLE--GNSQYEGYGVDLIKELADKLGFNFTFVN-GGNDYGSYN 481
            |....:.:....||....||.::|.  ||:.|:||.||||..:|..:||.:.||. ....||..:
  Fly   420 KMIYRVATRIGPPYFSYNETARELNLTGNALYQGYAVDLIDAIARHVGFEYVFVPVADQQYGKLD 484

  Fly   482 KSTNESTGMLREIMTGRADLAITDLTITSEREQALDFTIPFMNLGIAILYLKPQKATPELFTFMD 546
            |.|.:..|::.||:...|.:.|.|||||..|:.|:|||:|||.||::||..|.......|..::.
  Fly   485 KETKQWNGIIGEIINNDAHMGICDLTITQARKTAVDFTVPFMQLGVSILAYKSPHVEKTLDAYLA 549

  Fly   547 PFSEEVW-WFLGFSFLGVSLSFF--ILGRLSPSEWDNPYPCIEEPEELENQFTLGNSIWFTTGAL 608
            ||..||| |.|...|:   ::|.  |:.|:|..:|:||:||..:||.||||:.:.|:.|.|..::
  Fly   550 PFGGEVWIWILISVFV---MTFLKTIVARISKMDWENPHPCNRDPEVLENQWRIHNTGWLTVASI 611

  Fly   609 LQQGSEIGPKALSTRTVASFWWFFTLIVVSSYTANLAAFLTIEKPQSLINSVDDLADNKD---GV 670
            :..|.:|.|::...|...:.||.|.:|:.:|||||||||||..|.:..|.::.||:..|.   |.
  Fly   612 MTAGCDILPRSPQVRMFEATWWIFAIIIANSYTANLAAFLTSSKMEGSIANLKDLSAQKKVKFGT 676

  Fly   671 VYGAKKTGSTRNFFMTSAEERYK-KMNKFMSENPQYLTEDNMEGVNRVKTNT-HYAFLMESTSIE 733
            :||    |||.|....|.|..|: ..|...:::|...|:||:|||:||:.|. .|.||||:|::|
  Fly   677 IYG----GSTYNLLADSNETVYRLAFNLMNNDDPSAYTKDNLEGVDRVRKNRGDYMFLMETTTLE 737

  Fly   734 YNTKRECNLKKIGDALDEKGYGIAMRKDWPHRGKFNNALLELQEQGVLEKMKNKWWNEVGTGICA 798
            |:.::.|:|:.:|:...||.|.||:.....:|...:.|:|:|.|:|.|..:|.|||...... |.
  Fly   738 YHREQNCDLRSVGEKFGEKHYAIAVPFGAEYRSNLSVAILKLSERGELYDLKQKWWKNPNAS-CF 801

  Fly   799 TKEDAPDATP-LDMNNLEGVFFVLLVGSCCALLYGIISWVLFVMKKAHHYRVPLRDALKEEFQFV 862
            .:.| ||||| :....|.|:|:.|..|...|.|.||..::::|.:.|...|:..:||.|:|.:||
  Fly   802 EEPD-PDATPDMTFEELRGIFYTLYAGILIAFLIGITEFLVYVQQVALEERLTFKDAFKKEIRFV 865

  Fly   863 I-DFNNYVRVLKNS--ASIYSRSRQS 885
            : .:||...::..:  :|:.:..|:|
  Fly   866 LCVWNNRKPIVAGTPISSVRTTPRRS 891

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIE	NP_001036733.1	PBP1_iGluR_Kainate	42..396	CDD:107377	89/395 (23%)
		ANF_receptor	51..382	CDD:279440	85/372 (23%)
		PBP2_iGluR_Kainate	419..790	CDD:270432	145/381 (38%)
		Lig_chan	551..824	CDD:278489	107/281 (38%)
GluRIIC	NP_608557.4	PBP1_iGluR_Kainate	26..404	CDD:107377	94/411 (23%)
		Periplasmic_Binding_Protein_Type_1	<279..363	CDD:299141	24/94 (26%)
		PBP2_iGluR_Kainate	423..794	CDD:270432	144/377 (38%)
		Lig_chan	554..828	CDD:278489	107/282 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462605
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	137	1.000	Inparanoid score	I1813
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D17567at33392
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	7.000