DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIE and Ir21a

DIOPT Version :9

Sequence 1:	NP_001036733.1	Gene:	GluRIIE / 318623	FlyBaseID:	FBgn0051201	Length:	897	Species:	Drosophila melanogaster
Sequence 2:	NP_001097043.1	Gene:	Ir21a / 33157	FlyBaseID:	FBgn0031209	Length:	842	Species:	Drosophila melanogaster

Alignment Length:	809	Identity:	175/809 - (21%)
Similarity:	284/809 - (35%)	Gaps:	231/809 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   198 NGNYKQVLRRVRKSVDNRIVVVGSSETMPEFLNQAQQVGIINEDYKYIIGNLDFHSFDLEEYKYS 262
            :||.:...|:.|     |||........|.                   |.|....|.:..|.:.
  Fly    52 DGNNENEFRQKR-----RIVPTFQGNPRPR-------------------GELLASKFHVNSYNFE 92

  Fly   263 EAN-ITGLRLFSPEKMAVKELLMKLGYPTDQDEFRNGS-----------CPITV---EMALTYDA 312
            :.| :.||    ..|:| :|.|.|.......|.|...|           .|||.   |:...|:|
  Fly    93 QTNSLVGL----VNKIA-QEYLNKCPPVIYYDSFVEKSDGLILENLFKTIPITFYHGEINADYEA 152

  Fly   313 VQLFAQTLKNLPF-KPMPQNCSQ-----------------RTES------------VRDDGSS-- 345
                    ||..| ..:..||..                 :|||            :||..||
  Fly   153 --------KNKRFTSHIDCNCKSYILFLSDPLMTRKILGPQTESRVVLVSRSTQWRLRDFLSSEL 209

  Fly   346 FKNYMRTLRLTDRLLTGPIYFEGNVRKGYHLDVIELQPSGI-----VKVGTWDEDRQYRPQ-RLA 404
            ..|.:..|.:.:.|:..|:.     .:.|.|...:|...|:     |.:.:|.:....||. .|.
  Fly   210 SSNIVNLLVIGESLMADPMR-----ERPYVLYTHKLYADGLGSNTPVVLTSWIKGALSRPHINLF 269

  Fly   405 PTTAQFDSVDNSLANKTFIILLSVPNKPYAQLVETYKQLE----GNSQYEGYGVDLIKELADKLG 465
            |:..||     ..|...|.|  |..|:|  ..:...:.|:    |..:::|....|:..::.:|.
  Fly   270 PSKFQF-----GFAGHRFQI--SAANQP--PFIFRIRTLDSSGMGQLRWDGVEFRLLTMISKRLN 325

  Fly   466 FNFTFVNGGNDYGSYNKSTNESTGML----REIMTGRADLAITDLTITSEREQALDFTIPFMNLG 526
            |:.....        ..:.:.:.|::    .:|:....|:.::.:.||.||  .:|..   |::|
  Fly   326 FSIDITE--------TPTRSNTRGVVDTIQEQIIERTVDIGMSGIYITQER--LMDSA---MSVG 377

  Fly   527 ----IAILYLKPQKATPELFTFMDPFSEEVWWFLGFSFLGVSLSFFILGRLSPS----EWDNPYP 583
                .|.......||.|:....|.||...||..|...:||.........||:.|    .|.
  Fly   378 HSPDCAAFITLASKALPKYRAIMGPFQWPVWVALICVYLGGIFPIVFTDRLTLSHLMGNWG---- 438

  Fly   584 CIEEPEELENQFTLGNSIWFTTGALLQQGSEIG------PKALSTRTVASFWWFFTLIVVSSYTA 642
                  |:||.|      |:..|......|..|      .:..|||.:...:|.||:|:.|.||.
  Fly   439 ------EVENMF------WYVFGMFTNAFSFTGKYSWSNTRKNSTRLLIGAYWLFTIIITSCYTG 491

  Fly   643 NLAAFLTIEKPQSLINSVDDLADNKDGVVY--GAKKTGSTRNFFMTS----AEERYKKMNKFMSE 701
            ::.||:|:......::||.||.    |:.:  |....|....:|..|    ....||||....|.
  Fly   492 SIIAFVTLPAFPDTVDSVLDLL----GLFFRVGTLNNGGWETWFQNSTHIPTSRLYKKMEFVGSV 552

  Fly   702 NPQYLTEDNMEGVNRVKTN--THYAFLMESTSIEY---------NTKRECNLKKIGDALDEKGY- 754
            :         ||:..|..:  .:||||.....:||         |..|...|.     |.|:.:
  Fly   553 D---------EGIGNVTQSFFWNYAFLGSKAQLEYLVQSNFSDENISRRSALH-----LSEECFA 603

  Fly   755 ----GIAMRKDWPHRGKFNNALLELQEQGVLEKMKNK--W---WNEVGTGICAT-----KEDAPD 805
                |....::..::.|.::.:|..|:.|::.|:.|:  |   .:..|..:.|:     :|...:
  Fly   604 LFQIGFLFPRESVYKIKIDSMILLAQQSGLIAKINNEVSWVMQRSSSGRLLQASSSNSLREIIQE 668

  Fly   806 ATPLDMNNLEGVFFVLLVG---SCCALLYGIISWVLFVMKKAHHYRVPLRDALKEEFQFVIDFNN 867
            ...|...:.||:|.::.:|   ...||:..|:..   :..|.       |..:|
  Fly   669 ERQLTTADTEGMFLLMALGYFLGATALVSEIVGG---ITNKC-------RQIIK----------- 712

  Fly   868 YVRVLKNSASIYSRSRQSSMSVASVAQES 896
              |..|::||.:|.:...||...:..|.|
  Fly   713 --RSRKSAASSWSSASSGSMLRTNAEQLS 739

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIE	NP_001036733.1	PBP1_iGluR_Kainate	42..396	CDD:107377	51/249 (20%)
		ANF_receptor	51..382	CDD:279440	47/230 (20%)
		PBP2_iGluR_Kainate	419..790	CDD:270432	94/419 (22%)
		Lig_chan	551..824	CDD:278489	73/314 (23%)
Ir21a	NP_001097043.1	Periplasmic_Binding_Protein_Type_2	289..583	CDD:304360	77/337 (23%)
Ir21a	NP_001097043.1	Lig_chan	407..662	CDD:278489	68/288 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.910