DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GluRIIE and Ir7b

DIOPT Version :9

Sequence 1:	NP_001036733.1	Gene:	GluRIIE / 318623	FlyBaseID:	FBgn0051201	Length:	897	Species:	Drosophila melanogaster
Sequence 2:	NP_572410.2	Gene:	Ir7b / 31690	FlyBaseID:	FBgn0029965	Length:	655	Species:	Drosophila melanogaster

Alignment Length:	473	Identity:	87/473 - (18%)
Similarity:	161/473 - (34%)	Gaps:	119/473 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   444 EGNSQYEGYGVDLIKELADKLGFNFTFVNGGNDYGSY--NK-----STNESTGMLREIMTGRADL 501
            :|:..:.|....|::.:|:.|  |||       .|.|  ||     :.:||..:..||....||.
  Fly   228 DGSGSFVGIEGALLQFMAENL--NFT-------VGLYWMNKEEVLATFDESGRIFDEIFGHHADF 283

  Fly   502 AITDLTITSEREQALDF---TIPFMNLGIAILYLKPQKATPELFTFMDPFSEEVWWFLGFSFLGV 563
            ::............:.:   |..||:..:.:..|:...:..|..:|  ||:..:|..:|...:..
  Fly   284 SLGGFHFKPSAGSEIPYSQSTYYFMSHIMLVTNLQSAYSAYEKLSF--PFTPLLWRAIGLVLILA 346

  Fly   564 SLSFFILGRLSPSEWDNPYPCIEEPEELENQFTLGNSI---WFTTGALLQQGSEIGPKALSTRTV 625
            .|...:|.|     |.:.:.....|.......|:|.::   |.             |:...:|.|
  Fly   347 CLLLMLLVR-----WRHHHELPRNPYYELLVLTMGGNLEDRWV-------------PQRFPSRLV 393

  Fly   626 ASFWWFFTLIVVSSYTANLAAFL---TIEKPQSLINSVDDLADNKDGVVYGAKKTGSTRNFFMTS 687
            ...|.|.||::.|.|.:.:...|   |...|...|:.|  ||                ::|.:..
  Fly   394 LLTWLFATLVLRSGYQSGMYQLLRQDTQRNPPQTISEV--LA----------------QHFTIQL 440

  Fly   688 AEERYKKMNKFMSE-NPQYLTEDNMEGVN---------------RVKTNTHYAFLMESTSIEYNT 736
            ||....::...:.| .|:.|.  .:||..               ||...|.|.:......:...:
  Fly   441 AEVNEARILASLPELRPEQLV--YLEGSELQSFPALAQQSGSSARVAILTPYEYFGYFRKVHPMS 503

  Fly   737 KRECNLKKIGDALDEKGYGIAMRKDWPHRGKFNNALLELQEQGVLEKMKNKWWNEV--------- 792
            :|   |..:.:.:..:.....:|:.....|..|..:......|.||....::.:.|
  Fly   504 RR---LHLVRERIYTQQLAFYVRRHSHLVGVLNKQIQHAHTHGFLEHWTRQYVSAVDEKDESVAR 565

  Fly   793 -------------GTGICATKEDAPDATP-----LDMNNLEGVFFVLLVGSCCALLYGIISWVLF 839
                         |....:..|:.....|     |.|..|..:|:::|..:..|::..::..:|
  Fly   566 IASTSYSTLDGIDGDPSLSESEEDQQVAPVRQNVLSMRELAALFWLILWANLGAVVVFVLELLL- 629

  Fly   840 VMKKAHHYRVPLRDALKE 857
                   .|:.||..|::
  Fly   630 -------PRIKLRKILRK 640

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIE	NP_001036733.1	PBP1_iGluR_Kainate	42..396	CDD:107377
		ANF_receptor	51..382	CDD:279440
		PBP2_iGluR_Kainate	419..790	CDD:270432	72/377 (19%)
		Lig_chan	551..824	CDD:278489	55/321 (17%)
Ir7b	NP_572410.2	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462871
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840