Protein Alignment GluRIIE and Grik3

DIOPT Version :10

• Sequence 1: NP_001036733.1
• Gene: GluRIIE / 318623
• FlyBaseID: FBgn0051201
• Length: 897
• Species: Drosophila melanogaster
• Sequence 2: NP_001106187.1
• Gene: Grik3 / 298521
• RGDID: 71027
• Length: 919
• Species: Rattus norvegicus
• Alignment Length: 852
• Identity: 294/852 - (34%)
• Similarity: 465/852 - (54%)
• Gaps: 70/852 - (8%)

  Fly    48 NTEQMNI---VFDHAIDVANQE----VGTSLTSLKEEVNYGDAYQSYGKLCRMLETGIAGVFGPS 105
            |.:.||.   .|..:.::.|:.    ..|:||...:.:::.|::::..|.|..|..|:..:||||
  Rat    49 NAQVMNAEEHAFRFSANIINRNRTLLPNTTLTYDIQRIHFHDSFEATKKACDQLALGVVAIFGPS 113

  Fly   106 SRHTAVHLMSICDAMDIPHIY----SYMSENAEGF--NLHPHPADLAKALYSLITEFNWTRFIFL 164
            .......:.|||:|:::|||.    .:..:|.:.|  ||:|..|.|:.|:..|:....|.....:
  Rat   114 QGSCTNAVQSICNALEVPHIQLRWKHHPLDNKDTFYVNLYPDYASLSHAILDLVQSLKWRSATVV 178

  Fly   165 YESAEYLNILNELTTMLGKSGTVITVLRYDMQL--------NGNYKQVLRRVRKSVDNRIVVVGS 221
            |:.:..|..|.||         ::...||:::|        :.:.:.:|:.:::..:.||:...|
  Rat   179 YDDSTGLIRLQEL---------IMAPSRYNIRLKIRQLPIDSDDSRPLLKEMKRGREFRIIFDCS 234

  Fly   222 SETMPEFLNQAQQVGIINEDYKYIIGNLDFHSFDLEEYKYSEANITGLRLFSPEKMAVKELLMKL 286
            .....:.|.||..:|::.|.|.:|...||.::.|||.|:||..|:||.|:.:.:...|..::.|.
  Rat   235 HTMAAQILKQAMAMGMMTEYYHFIFTTLDLYALDLEPYRYSGVNLTGFRILNVDNPHVSAIVEKW 299

  Fly   287 GY------PTDQDEFRNGSCPITVEMALTYDAVQLFAQTLKNLPFKPMPQNCSQ--RTESVRDDG 343
            ..      |..:....:|  .:..:.||.||||.:.:...:..|  .|..|..|  |.::.| .|
  Rat   300 SMERLQAAPRAESGLLDG--VMMTDAALLYDAVHIVSVCYQRAP--QMTVNSLQCHRHKAWR-FG 359

  Fly   344 SSFKNYMRTLRLTDRLLTGPIYFE--GNVRKGYHLDVIELQPSGIVKVGTWDEDRQYRPQRLAPT 406
            ..|.|:::..:...  |||.|.|.  ..:|..:.||:|.|:..|:.|||.|..........:|
  Rat   360 GRFMNFIKEAQWEG--LTGRIVFNKTSGLRTDFDLDIISLKEDGLEKVGVWSPADGLNITEVA-- 420

  Fly   407 TAQFDSVDNSLANKTFIILLSVPNKPYAQLVETYKQLEGNSQYEGYGVDLIKELADKLGFNF--T 469
            ..:..:|.:||.|:: :|:.::..:|:....::.:.|.||.::|||.:||:||||..|||::  .
  Rat   421 KGRGPNVTDSLTNRS-LIVTTLLEEPFVMFRKSDRTLYGNDRFEGYCIDLLKELAHILGFSYEIR 484

  Fly   470 FVNGG-----NDYGSYNKSTNESTGMLREIMTGRADLAITDLTITSEREQALDFTIPFMNLGIAI 529
            .|..|     :|.|.:|       ||::|::..:||||:..||||..||:|:||:.|||.||::|
  Rat   485 LVEDGKYGAQDDKGQWN-------GMVKELIDHKADLAVAPLTITHVREKAIDFSKPFMTLGVSI 542

  Fly   530 LYLKPQKATPELFTFMDPFSEEVWWFLGFSFLGVSLSFFILGRLSPSEWDNPYPCIEEPEELENQ 594
            ||.||....|.:|:|::|.|.::|.::..::||||...|::.|.||.||.:.:||....|.:||.
  Rat   543 LYRKPNGTNPSVFSFLNPLSPDIWMYVLLAYLGVSCVLFVIARFSPYEWYDAHPCNPGSEVVENN 607

  Fly   595 FTLGNSIWFTTGALLQQGSEIGPKALSTRTVASFWWFFTLIVVSSYTANLAAFLTIEKPQSLINS 659
            |||.||.||..|:|:|||||:.|||||||.:...|||||||::||||||||||||:|:.:|.|:|
  Rat   608 FTLLNSFWFGMGSLMQQGSELMPKALSTRIIGGIWWFFTLIIISSYTANLAAFLTVERMESPIDS 672

  Fly   660 VDDLADNKDGVVYGAKKTGSTRNFFMTSAEERYKKMNKFMSENPQYLTEDNMEGVNRVKTNTHYA 724
            .|||| .:..:.|||.|.|:|..||..|....::||..|||..|..|.::|.||:.|..| ..||
  Rat   673 ADDLA-KQTKIEYGAVKDGATMTFFKKSKISTFEKMWAFMSSKPSALVKNNEEGIQRTLT-ADYA 735

  Fly   725 FLMESTSIEYNTKRECNLKKIGDALDEKGYGIAMRKDWPHRGKFNNALLELQEQGVLEKMKNKWW 789
            .|||||:|||.|:|.|||.:||..:|.|||||......|:|.|...|:|:|||:..|..||.|||
  Rat   736 LLMESTTIEYITQRNCNLTQIGGLIDSKGYGIGTPMGSPYRDKITIAILQLQEEDKLHIMKEKWW 800

  Fly   790 NEVGTGICATKEDAPDATPLDMNNLEGVFFVLLVGSCCALLYGIISWVLFVMKKAHHYRVPLRDA 854
            .  |:|  ..:|:..:|:.|.:..:.|:|.||..|...::|..:..::..:.|.|...:......
  Rat   801 R--GSG--CPEEENKEASALGIQKIGGIFIVLAAGLVLSVLVAVGEFIYKLRKTAEREQRSFCST 861

  Fly   855 LKEEFQF 861
            :.:|.:|
  Rat   862 VADEIRF 868

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIE	NP_001036733.1	PBP1_iGluR_Kainate	40..402	CDD:380605	99/384 (26%)
		PBP2_iGluR_Kainate	419..790	CDD:270432	175/377 (46%)
		Lig_chan	551..824	CDD:459656	131/272 (48%)
Grik3	NP_001106187.1	PBP1_iGluR_Kainate	37..417	CDD:380605	99/383 (26%)
		PBP2_iGluR_Kainate_GluR7	433..801	CDD:270441	175/377 (46%)