DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GluRIIE and Grik3

DIOPT Version :9

Sequence 1:	NP_001036733.1	Gene:	GluRIIE / 318623	FlyBaseID:	FBgn0051201	Length:	897	Species:	Drosophila melanogaster
Sequence 2:	NP_001106187.1	Gene:	Grik3 / 298521	RGDID:	71027	Length:	919	Species:	Rattus norvegicus

Alignment Length:	852	Identity:	294/852 - (34%)
Similarity:	465/852 - (54%)	Gaps:	70/852 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 NTEQMNI---VFDHAIDVANQE----VGTSLTSLKEEVNYGDAYQSYGKLCRMLETGIAGVFGPS 105
            |.:.||.   .|..:.::.|:.    ..|:||...:.:::.|::::..|.|..|..|:..:||||
  Rat    49 NAQVMNAEEHAFRFSANIINRNRTLLPNTTLTYDIQRIHFHDSFEATKKACDQLALGVVAIFGPS 113

  Fly   106 SRHTAVHLMSICDAMDIPHIY----SYMSENAEGF--NLHPHPADLAKALYSLITEFNWTRFIFL 164
            .......:.|||:|:::|||.    .:..:|.:.|  ||:|..|.|:.|:..|:....|.....:
  Rat   114 QGSCTNAVQSICNALEVPHIQLRWKHHPLDNKDTFYVNLYPDYASLSHAILDLVQSLKWRSATVV 178

  Fly   165 YESAEYLNILNELTTMLGKSGTVITVLRYDMQL--------NGNYKQVLRRVRKSVDNRIVVVGS 221
            |:.:..|..|.||         ::...||:::|        :.:.:.:|:.:::..:.||:...|
  Rat   179 YDDSTGLIRLQEL---------IMAPSRYNIRLKIRQLPIDSDDSRPLLKEMKRGREFRIIFDCS 234

  Fly   222 SETMPEFLNQAQQVGIINEDYKYIIGNLDFHSFDLEEYKYSEANITGLRLFSPEKMAVKELLMKL 286
            .....:.|.||..:|::.|.|.:|...||.::.|||.|:||..|:||.|:.:.:...|..::.|.
  Rat   235 HTMAAQILKQAMAMGMMTEYYHFIFTTLDLYALDLEPYRYSGVNLTGFRILNVDNPHVSAIVEKW 299

  Fly   287 GY------PTDQDEFRNGSCPITVEMALTYDAVQLFAQTLKNLPFKPMPQNCSQ--RTESVRDDG 343
            ..      |..:....:|  .:..:.||.||||.:.:...:..|  .|..|..|  |.::.| .|
  Rat   300 SMERLQAAPRAESGLLDG--VMMTDAALLYDAVHIVSVCYQRAP--QMTVNSLQCHRHKAWR-FG 359

  Fly   344 SSFKNYMRTLRLTDRLLTGPIYFE--GNVRKGYHLDVIELQPSGIVKVGTWDEDRQYRPQRLAPT 406
            ..|.|:::..:...  |||.|.|.  ..:|..:.||:|.|:..|:.|||.|..........:|
  Rat   360 GRFMNFIKEAQWEG--LTGRIVFNKTSGLRTDFDLDIISLKEDGLEKVGVWSPADGLNITEVA-- 420

  Fly   407 TAQFDSVDNSLANKTFIILLSVPNKPYAQLVETYKQLEGNSQYEGYGVDLIKELADKLGFNF--T 469
            ..:..:|.:||.|:: :|:.::..:|:....::.:.|.||.::|||.:||:||||..|||::  .
  Rat   421 KGRGPNVTDSLTNRS-LIVTTLLEEPFVMFRKSDRTLYGNDRFEGYCIDLLKELAHILGFSYEIR 484

  Fly   470 FVNGG-----NDYGSYNKSTNESTGMLREIMTGRADLAITDLTITSEREQALDFTIPFMNLGIAI 529
            .|..|     :|.|.:|       ||::|::..:||||:..||||..||:|:||:.|||.||::|
  Rat   485 LVEDGKYGAQDDKGQWN-------GMVKELIDHKADLAVAPLTITHVREKAIDFSKPFMTLGVSI 542

  Fly   530 LYLKPQKATPELFTFMDPFSEEVWWFLGFSFLGVSLSFFILGRLSPSEWDNPYPCIEEPEELENQ 594
            ||.||....|.:|:|::|.|.::|.::..::||||...|::.|.||.||.:.:||....|.:||.
  Rat   543 LYRKPNGTNPSVFSFLNPLSPDIWMYVLLAYLGVSCVLFVIARFSPYEWYDAHPCNPGSEVVENN 607

  Fly   595 FTLGNSIWFTTGALLQQGSEIGPKALSTRTVASFWWFFTLIVVSSYTANLAAFLTIEKPQSLINS 659
            |||.||.||..|:|:|||||:.|||||||.:...|||||||::||||||||||||:|:.:|.|:|
  Rat   608 FTLLNSFWFGMGSLMQQGSELMPKALSTRIIGGIWWFFTLIIISSYTANLAAFLTVERMESPIDS 672

  Fly   660 VDDLADNKDGVVYGAKKTGSTRNFFMTSAEERYKKMNKFMSENPQYLTEDNMEGVNRVKTNTHYA 724
            .|||| .:..:.|||.|.|:|..||..|....::||..|||..|..|.::|.||:.|..| ..||
  Rat   673 ADDLA-KQTKIEYGAVKDGATMTFFKKSKISTFEKMWAFMSSKPSALVKNNEEGIQRTLT-ADYA 735

  Fly   725 FLMESTSIEYNTKRECNLKKIGDALDEKGYGIAMRKDWPHRGKFNNALLELQEQGVLEKMKNKWW 789
            .|||||:|||.|:|.|||.:||..:|.|||||......|:|.|...|:|:|||:..|..||.|||
  Rat   736 LLMESTTIEYITQRNCNLTQIGGLIDSKGYGIGTPMGSPYRDKITIAILQLQEEDKLHIMKEKWW 800

  Fly   790 NEVGTGICATKEDAPDATPLDMNNLEGVFFVLLVGSCCALLYGIISWVLFVMKKAHHYRVPLRDA 854
            .  |:|  ..:|:..:|:.|.:..:.|:|.||..|...::|..:..::..:.|.|...:......
  Rat   801 R--GSG--CPEEENKEASALGIQKIGGIFIVLAAGLVLSVLVAVGEFIYKLRKTAEREQRSFCST 861

  Fly   855 LKEEFQF 861
            :.:|.:|
  Rat   862 VADEIRF 868

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIE	NP_001036733.1	PBP1_iGluR_Kainate	42..396	CDD:107377	99/378 (26%)
		ANF_receptor	51..382	CDD:279440	92/361 (25%)
		PBP2_iGluR_Kainate	419..790	CDD:270432	175/377 (46%)
		Lig_chan	551..824	CDD:278489	131/272 (48%)
Grik3	NP_001106187.1	PBP1_iGluR_Kainate_GluR5_7	34..417	CDD:107388	99/383 (26%)
		ANF_receptor	55..398	CDD:279440	90/358 (25%)
		PBP2_iGluR_Kainate_GluR7	433..801	CDD:270441	175/377 (46%)
		Lig_chan	564..832	CDD:278489	131/273 (48%)
		Glutamate binding	690..692		1/1 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349881
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	1	1.010	-	-		D60688at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.660