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Protein Alignment GluRIIE and GRIN2D

DIOPT Version :9

Sequence 1:	NP_001036733.1	Gene:	GluRIIE / 318623	FlyBaseID:	FBgn0051201	Length:	897	Species:	Drosophila melanogaster
Sequence 2:	NP_000827.2	Gene:	GRIN2D / 2906	HGNCID:	4588	Length:	1336	Species:	Homo sapiens

Alignment Length:	897	Identity:	200/897 - (22%)
Similarity:	359/897 - (40%)	Gaps:	167/897 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 AIDVANQEVGTSLTSLKEEVNYGDAYQSYGKLCRMLETGI---AGVFGPSSRHTAV----HLMSI 116
            |:..|.:..|..:..:...:|..|......:||.:| :|:   ..||...||..||    ..:|.
Human    72 AVAAAVRSPGLDVRPVALVLNGSDPRSLVLQLCDLL-SGLRVHGVVFEDDSRAPAVAPILDFLSA 135

  Fly   117 CDAMDIPHIYS----YMSENAEG---FNLHPHPADLAKALYSLITEFNWTRFIFLYESA------ 168
            ..::.|..::.    .::...:|   ..|........:.::.::.|::||.|:.:...|
Human   136 QTSLPIVAVHGGAALVLTPKEKGSTFLQLGSSTEQQLQVIFEVLEEYDWTSFVAVTTRAPGHRAF 200

  Fly   169 -EYLNILNE-----------LTTMLGKSGTVITVLRYDMQLNGNYKQVLRRVRKSVDNRIVVVGS 221
             .|:.:|.:           ||...|....|::.             .||.|  |...|::....
Human   201 LSYIEVLTDGSLVGWEHRGALTLDPGAGEAVLSA-------------QLRSV--SAQIRLLFCAR 250

  Fly   222 SETMPEFLNQAQQVGIINEDYK-YIIGNLDFHSFDLEEYKYSEANITGLRLFSPEKMAVKELLMK 285
            .|..|.| ..|::.|:....|. :::|.           :.:....:|.....|        |:.
Human   251 EEAEPVF-RAAEEAGLTGSGYVWFMVGP-----------QLAGGGGSGAPGEPP--------LLP 295

  Fly   286 LGYPTDQDEFRNGSCPITVEMALTYDA-VQLFAQ----TLKNLPFKP-MPQNCSQRTESVRDDGS 344
            .|.|.....|...|.....::|....| |.:.|:    .|::..|.| :..:|..:..:.|  |.
Human   296 GGAPLPAGLFAVRSAGWRDDLARRVAAGVAVVARGAQALLRDYGFLPELGHDCRAQNRTHR--GE 358

  Fly   345 SFKNYMRTLRLTDRLLTGPIYFEGNVRKGYHLDVIELQPSGIV----------KVGTWDEDRQYR 399
            |...|...:...:|            ...::.|...:.||.:|          .||:|::.....
Human   359 SLHRYFMNITWDNR------------DYSFNEDGFLVNPSLVVISLTRDRTWEVVGSWEQQTLRL 411

  Fly   400 PQRLAPTTAQF-DSVDN-------SLANKTFIILL------------SVPNKPYAQLVETYKQLE 444
            ...|.....:| ..||:       :|..:.|:|:.            |||.:  :||..|:....
Human   412 KYPLWSRYGRFLQPVDDTQHLTVATLEERPFVIVEPADPISGTCIRDSVPCR--SQLNRTHSPPP 474

  Fly   445 GNSQYE-----GYGVDLIKELADKLGFNFTFVNGGNDYGSYNKSTNES-TGMLREIMTGRADLAI 503
            ...:.|     |:.:|::|.||..:||::......|  |.:.|..:.. .||:.|:...|||:||
Human   475 DAPRPEKRCCKGFCIDILKRLAHTIGFSYDLYLVTN--GKHGKKIDGVWNGMIGEVFYQRADMAI 537

  Fly   504 TDLTITSEREQALDFTIPFMNLGIAILYLKPQKATPELFTFMDPFSEEVWWFLGFSFLG-VSLSF 567
            ..|||..||.:.:||::||:..||:::..: ...|.....|::|:|..||..:....|. |:::.
Human   538 GSLTINEERSEIVDFSVPFVETGISVMVAR-SNGTVSPSAFLEPYSPAVWVMMFVMCLTVVAVTV 601

  Fly   568 FILGRLSPSEWDNPYPCIEEPEELENQFTLGNSIWFTTGALLQQGSEI-GPKALSTRTVASFWWF 631
            ||...|||..::......:.|.  .:.||:|.|||.....:......: .|:..:::.:...|.|
Human   602 FIFEYLSPVGYNRSLATGKRPG--GSTFTIGKSIWLLWALVFNNSVPVENPRGTTSKIMVLVWAF 664

  Fly   632 FTLIVVSSYTANLAAFLTIEKPQSLINSVDDLADNK--------DGVVYGAKKTGSTRNFFMTSA 688
            |.:|.::|||||||||:..|:   .:::|..|:|.|        ..:.:|....|||..    :.
Human   665 FAVIFLASYTANLAAFMIQEE---YVDTVSGLSDRKFQRPQEQYPPLKFGTVPNGSTEK----NI 722

  Fly   689 EERYKKMNKFMSENPQYLTEDNMEGVNRVKTNTHYAFLMESTSIEYNTKRE--CNLKKIGD--AL 749
            ...|..|:.:|....|...|   |.:.::|.....||:.::..:.|..:::  |.|..||.  ..
Human   723 RSNYPDMHSYMVRYNQPRVE---EALTQLKAGKLDAFIYDAAVLNYMARKDEGCKLVTIGSGKVF 784

  Fly   750 DEKGYGIAMRKDWPHRGKFNNALLELQEQGVLEKMKNKWWNEVGTGICATKEDAPDATPLDMNNL 814
            ...|||||:.|....:...:.|||:......:|.::..|.    :|||...:....::.||::|:
Human   785 ATTGYGIALHKGSRWKRPIDLALLQFLGDDEIEMLERLWL----SGICHNDKIEVMSSKLDIDNM 845

  Fly   815 EGVFFVLLVGSCCALLYGIISWVLFVMKKAHHYRVPLRDALKEEFQFVIDFN 866
            .|||::|||....:||  :.:|...|..:..|...|     .....|::.|:
Human   846 AGVFYMLLVAMGLSLL--VFAWEHLVYWRLRHCLGP-----THRMDFLLAFS 890

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.