Protein Alignment GluRIIE and GRIN2C

DIOPT Version :10

• Sequence 1: NP_001036733.1
• Gene: GluRIIE / 318623
• FlyBaseID: FBgn0051201
• Length: 897
• Species: Drosophila melanogaster
• Sequence 2: XP_054171851.1
• Gene: GRIN2C / 2905
• HGNCID: 4587
• Length: 1265
• Species: Homo sapiens
• Alignment Length: 969
• Identity: 214/969 - (22%)
• Similarity: 362/969 - (37%)
• Gaps: 290/969 - (29%)

  Fly    94 LETGIAGVFGPSSRHTAVHLMSICDAMDIPHIYSYMSENAE------------------------ 134
            |.|.|.|:.|.:..|..|...:: |...:..|..::|....
Human    77 LLTQICGLLGAAHVHGIVFEDNV-DTEAVAQILDFISSQTHVPILSISGGSAVVLTPKEPGSAFL 140

  Fly   135 --GFNLHPHPADLAKALYSLITEFNWTRF-----------IFL-----YESAEYLN--ILNELTT 179
              |.:|...    .:.|:.::.|::|:.|           :||     ...|.:::  :|:.:|.
Human   141 QLGVSLEQQ----LQVLFKVLEEYDWSAFAVITSLHPGHALFLEGVRAVADASHVSWRLLDVVTL 201

  Fly   180 MLGKSGTVITVLRYDMQLNGNYKQVLRRVRKSVDNRIVVVGSSETMPEFL-NQAQQVGIINEDYK 243
            .||..|.               :...:|:.:.:|..:.|...|....|.| .:|.|.|::...:.
Human   202 ELGPGGP---------------RARTQRLLRQLDAPVFVAYCSREEAEVLFAEAAQAGLVGPGHV 251

  Fly   244 YIIGNLDFHSFDLEEYKYSEANIT----GLRLFSPEKMAVKELLMKLG----------YPTDQDE 294
            :::.||...|.|.....:....|:    ..||...:|:.....::.||          .|....:
Human   252 WLVPNLALGSTDAPPATFPVGLISVVTESWRLSLRQKVRDGVAILALGAHSYWRQHGTLPAPAGD 316

  Fly   295 FRNGSCPITVEMALTYDAVQLFAQTLKNLPFKPMPQNCSQRTESVRDDGSSFKNYMRTLRLTDRL 359
            .|....|::       .|.:.|.:.|.|:            |...||...|...|:
Human   317 CRVHPGPVS-------PAREAFYRHLLNV------------TWEGRDFSFSPGGYL--------- 353

  Fly   360 LTGPIYFEGNVRKGYHLDVIELQPSGIV----------KVGTWDEDRQYRPQRLAPT-TAQFDSV 413
                                 :||:.:|          .||.|:....|....:.|. :|....|
Human   354 ---------------------VQPTMVVIALNRHRLWEMVGRWEHGVLYMKYPVWPRYSASLQPV 397

  Fly   414 DNS-------LANKTFIILLS--------VPN-----------------KPYAQLVETYKQLEGN 446
            .:|       |..:.|:|:.|        |||                 .||.:|.
Human   398 VDSRHLTVATLEERPFVIVESPDPGTGGCVPNTVPCRRQSNHTFSSGDVAPYTKLC--------- 453

  Fly   447 SQYEGYGVDLIKELADKLGFNFTFV------NGGNDYGSYNKSTNESTGMLREIMTGRADLAITD 505
              .:|:.:|::|:||..:.|::...      :|....|.:|       ||:.|:...|||:||..
Human   454 --CKGFCIDILKKLARVVKFSYDLYLVTNGKHGKRVRGVWN-------GMIGEVYYKRADMAIGS 509

  Fly   506 LTITSEREQALDFTIPFMNLGIAILYLKPQKATPELFTFMDPFSEEVWWFLGFSFLG-VSLSFFI 569
            |||..||.:.:||::||:..||:::..: ...|.....|::|:|..||..:....|. |:::.|:
Human   510 LTINEERSEIVDFSVPFVETGISVMVAR-SNGTVSPSAFLEPYSPAVWVMMFVMCLTVVAITVFM 573

  Fly   570 LGRLSPSEWDNPYPCIEEPEELENQ------------FTLGNSIWFTTGALLQQGSEI-GPKALS 621
            ....||..:              ||            ||:|.|:|.....:......| .|:..:
Human   574 FEYFSPVSY--------------NQNLTRGKKSGGPAFTIGKSVWLLWALVFNNSVPIENPRGTT 624

  Fly   622 TRTVASFWWFFTLIVVSSYTANLAAFLTIEKPQSLINSVDDLADNKD------GVVYGAKKT--- 677
            ::.:...|.||.:|.::|||||||||:..|:   .|::|..|:|.|.      ||.:.|.||
Human   625 SKIMVLVWAFFAVIFLASYTANLAAFMIQEQ---YIDTVSGLSDKKSLHLENTGVAWTAFKTFCS 686

  Fly   678 --------------------GST-RNFFMTSAEERYKKMNKFMSENPQYLTEDNMEGVNRVKTNT 721
                                ||| ||.     ...|:.|:..|.:..|...||   .:..:|..:
Human   687 DYFQRPQDQYPPFRFGTVPNGSTERNI-----RSNYRDMHTHMVKFNQRSVED---ALTSLKMGS 743

  Fly   722 HY--------AFLMESTSIEYNTKRE--CNLKKIGD--ALDEKGYGIAMRKDWPHRGKFNNALLE 774
            ..        ||:.::..:.|...::  |.|..||.  .....||||||:||...:...:.|||:
Human   744 EAQPVPRKLDAFIYDAAVLNYMAGKDEGCKLVTIGSGKVFATTGYGIAMQKDSHWKRAIDLALLQ 808

  Fly   775 LQEQGVLEKMKNKWWNEVGTGICATKEDAPDATPLDMNNLEGVFFVLLVGSCCALLYGIISWVLF 839
            ....|..:|::..|.    :|||..:::...::.||::|:.|||::|||....|||  :.:|...
Human   809 FLGDGETQKLETVWL----SGICQNEKNEVMSSKLDIDNMAGVFYMLLVAMGLALL--VFAWEHL 867

  Fly   840 VMKKAHHYRVPLRDALKEEFQFVIDFNNYV-RVLKNSASIYSRSRQSSMSV-ASVAQES 896
            |..|..| .||    ...:..|::.|:..: .......|:.|..||:|..: ||.||.|
Human   868 VYWKLRH-SVP----NSSQLDFLLAFSRGIYSCFSGVQSLASPPRQASPDLTASSAQAS 921

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIE	NP_001036733.1	PBP1_iGluR_Kainate	40..402	CDD:380605	62/376 (16%)
		PBP2_iGluR_Kainate	419..790	CDD:270432	114/457 (25%)
		Lig_chan	551..824	CDD:459656	84/328 (26%)
GRIN2C	XP_054171851.1	PBP1_iGluR_NMDA_NR2	28..384	CDD:380601	62/375 (17%)
		PBP2_iGluR_NMDA_Nr2	400..829	CDD:270436	119/476 (25%)
		NMDAR2_C	866..>941	CDD:463148	17/61 (28%)