back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIE and GRIN2B

DIOPT Version :9

Sequence 1:	NP_001036733.1	Gene:	GluRIIE / 318623	FlyBaseID:	FBgn0051201	Length:	897	Species:	Drosophila melanogaster
Sequence 2:	NP_000825.2	Gene:	GRIN2B / 2904	HGNCID:	4586	Length:	1484	Species:	Homo sapiens

Alignment Length:	891	Identity:	206/891 - (23%)
Similarity:	371/891 - (41%)	Gaps:	175/891 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 DNYQSLESVP-IGLLTDQNTEQMNIVFDHAIDVANQEVGTSLTSLKEE------VNYGDAYQSYG 88
            |::..|..|| :.|:....|:..:|:             |.:..|..:      |...|..|.
Human    57 DDFHHLSVVPRVELVAMNETDPKSII-------------TRICDLMSDRKIQGVVFADDTDQE-- 106

  Fly    89 KLCRMLE-------TGIAGVFGPSSRHTAVHLMSICDAMDIPHIYSYMSENAEGFNLHPHPADLA 146
            .:.::|:       |.|.|:.|.||       |.:.|          ..|::..|...|.....|
Human   107 AIAQILDFISAQTLTPILGIHGGSS-------MIMAD----------KDESSMFFQFGPSIEQQA 154

  Fly   147 KALYSLITEFNWTRFIFLYESA---EYLNILNELTTMLGKS---GTVITVLRYDMQLNGNYKQVL 205
            ..:.:::.|::|  :||...:.   .|.:.:|::.:.:..|   ..:..||..||.|:....::.
Human   155 SVMLNIMEEYDW--YIFSIVTTYFPGYQDFVNKIRSTIENSFVGWELEEVLLLDMSLDDGDSKIQ 217

  Fly   206 RRVRKSVDNRIVVVGSSETMPEFLNQAQQVGIINEDYKYIIGNLDFHSFDLEEYKYSEANITGLR 270
            .:::|.....|::..:.|........|..||:....|.:|:.:|.....|....::.    |||.
Human   218 NQLKKLQSPIILLYCTKEEATYIFEVANSVGLTGYGYTWIVPSLVAGDTDTVPAEFP----TGLI 278

  Fly   271 LFSPEKMAVKELLMKLGYPTDQDEFRNGSCPITVEMALTYDAVQLFAQTLKNLPFKPMPQNCSQR 335
            ..|.::       ...|.|.   ..|:|...||...          :..|....|.|.|::....
Human   279 SVSYDE-------WDYGLPA---RVRDGIAIITTAA----------SDMLSEHSFIPEPKSSCYN 323

  Fly   336 TESVRDDGSSFKNYMRTLRLTDRLLTGPIYFEGNVRKGYHLDVIELQPSGIV----------KVG 390
            |...|...|:..|         |.|.. :.|||. ...:..|..::.|..::          :||
Human   324 THEKRIYQSNMLN---------RYLIN-VTFEGR-NLSFSEDGYQMHPKLVIILLNKERKWERVG 377

  Fly   391 TWDED----RQYRPQRLAPTTAQFDSVDNSLANKT-----FIILLSVP---------NKPYAQLV 437
            .|.:.    :.|...|:.|.|.:.:  |:.|:..|     |:|:.||.         ..|..:.:
Human   378 KWKDKSLQMKYYVWPRMCPETEEQE--DDHLSIVTLEEAPFVIVESVDPLSGTCMRNTVPCQKRI 440

  Fly   438 ETYKQLEGNSQY-----EGYGVDLIKELADKLGFNFTFVNGGNDYGSYNKSTNES-TGMLREIMT 496
            .|..:.:....|     :|:.:|::|:::..:.|.:......|  |.:.|..|.: .||:.|::.
Human   441 VTENKTDEEPGYIKKCCKGFCIDILKKISKSVKFTYDLYLVTN--GKHGKKINGTWNGMIGEVVM 503

  Fly   497 GRADLAITDLTITSEREQALDFTIPFMNLGIAILYLKPQKATPELFTFMDPFSEEVWWFLGFSFL 561
            .||.:|:..|||..||.:.:||::||:..||::: :.....|.....|::|||.:||..:....|
Human   504 KRAYMAVGSLTINEERSEVVDFSVPFIETGISVM-VSRSNGTVSPSAFLEPFSADVWVMMFVMLL 567

  Fly   562 GVS-LSFFILGRLSPSEWDNPYPCIEEPEELEN-QFTLGNSIWFTTGALLQQGSEI-GPKALSTR 623
            .|| ::.|:....||..::.   |:.:..|... .||:|.:||...|.:......: .||..:::
Human   568 IVSAVAVFVFEYFSPVGYNR---CLADGREPGGPSFTIGKAIWLLWGLVFNNSVPVQNPKGTTSK 629

  Fly   624 TVASFWWFFTLIVVSSYTANLAAFLTIEKPQSLINSVDDLADNK--------DGVVYGAKKTGST 680
            .:.|.|.||.:|.::|||||||||:..|:   .::.|..|:|.|        ....:|....|||
Human   630 IMVSVWAFFAVIFLASYTANLAAFMIQEE---YVDQVSGLSDKKFQRPNDFSPPFRFGTVPNGST 691

  Fly   681 RNFFMTSAEERYKKMNKFMSENPQYLTEDNMEGVN----RVKTNTHYAFLMESTSIEYNTKRE-- 739
            ......:..|.:..|.||           |..||:    .:||....||:.::..:.|...|:
Human   692 ERNIRNNYAEMHAYMGKF-----------NQRGVDDALLSLKTGKLDAFIYDAAVLNYMAGRDEG 745

  Fly   740 CNLKKIGD--ALDEKGYGIAMRKDWPHRGKFNNALLELQEQGVLEKMKNKWWNEVGTGICATKED 802
            |.|..||.  .....|||||::||...:.:.:.|:|:|...|.:|:::..|.    ||||..:::
Human   746 CKLVTIGSGKVFASTGYGIAIQKDSGWKRQVDLAILQLFGDGEMEELEALWL----TGICHNEKN 806

  Fly   803 APDATPLDMNNLEGVFFVLLVGSCCALLYGIISWVLFVMKKAHHYR 848
            ...::.||::|:.|||::|  |:..||     |.:.|:.:...:::
Human   807 EVMSSQLDIDNMAGVFYML--GAAMAL-----SLITFICEHLFYWQ 845

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.