DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIE and GRIN2A

DIOPT Version :9

Sequence 1:	NP_001036733.1	Gene:	GluRIIE / 318623	FlyBaseID:	FBgn0051201	Length:	897	Species:	Drosophila melanogaster
Sequence 2:	XP_016878661.1	Gene:	GRIN2A / 2903	HGNCID:	4585	Length:	1516	Species:	Homo sapiens

Alignment Length:	973	Identity:	222/973 - (22%)
Similarity:	395/973 - (40%)	Gaps:	228/973 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 IVFDHAIDVANQEVGT-----SLTSLKEEVNY-------GDAYQSYGKLCRMLE-TGIAG-VFGP 104
            ::..|:.||..:|:.|     ....|..:||.       .|.......:|.::. ..|.| |||.
Human    90 VMLGHSHDVTERELRTLWGPEQAAGLPLDVNVVALLMNRTDPKSLITHVCDLMSGARIHGLVFGD 154

  Fly   105 S-------------SRHTAVHLMSICDAMDIPHIYSYMSENAEGFNLHPHPADLAKALYSLITEF 156
            .             |.||.|.::.|.....:  |.:.....:..|.........|..:..::.::
Human   155 DTDQEAVAQMLDFISSHTFVPILGIHGGASM--IMADKDPTSTFFQFGASIQQQATVMLKIMQDY 217

  Fly   157 NWTRF-----IFLYESAEYLNILNELTTMLGKSGTVITVLRYDMQ----LNGNYKQV-----LRR 207
            :|..|     ||    ..|...::.:.|.:..|     .:.:|||    |:.:::..     |::
Human   218 DWHVFSLVTTIF----PGYREFISFVKTTVDNS-----FVGWDMQNVITLDTSFEDAKTQVQLKK 273

  Fly   208 VRKSVDNRIVVVGSSETMPEFLNQAQQVGIINEDYKYII-----GNLD---------FHSFDLEE 258
            :..||   |::..|.:.....|::|:.:|:...|:.:|:     ||.:         ..|...::
Human   274 IHSSV---ILLYCSKDEAVLILSEARSLGLTGYDFFWIVPSLVSGNTELIPKEFPSGLISVSYDD 335

  Fly   259 YKYS-EANI-TGLRLFSPEKMAVKELLMKLGYPTDQDEFRNGSC---------------PITVEM 306
            :.|| ||.: .|:.:.:   .|...:|.|..|..:    ...||               |..|.
Human   336 WDYSLEARVRDGIGILT---TAASSMLEKFSYIPE----AKASCYGQMERPEVPMHTLHPFMVN- 392

  Fly   307 ALTYDAVQLFAQTLKNLPF-----KPMPQ------NCSQRTESVRDDGSSFKNYMRTLRLTDRLL 360
             :|:|.        |:|.|     :..|:      |..:..|.|    ..::|:..:||..
Human   393 -VTWDG--------KDLSFTEEGYQVHPRLVVIVLNKDREWEKV----GKWENHTLSLRHA---- 440

  Fly   361 TGPIY--FEGNVRKGYHLDVIELQPSGIVKVGTWDEDRQYRPQRLAPTTAQFDSVDNSLANKTFI 423
            ..|.|  |........||.::.|:.:..|.|    ||       :.|.|.  ..|.|::..:.|:
Human   441 VWPRYKSFSDCEPDDNHLSIVTLEEAPFVIV----ED-------IDPLTE--TCVRNTVPCRKFV 492

  Fly   424 ILLSVPNKPYAQLVETYKQLEGNSQYEGYGVDLIKELADKLGFNFTFVNGGNDYGSYNKSTNES- 487
               .:.|       .|.:.:......:|:.:|::|:|:..:.|.:......|  |.:.|..|..
Human   493 ---KINN-------STNEGMNVKKCCKGFCIDILKKLSRTVKFTYDLYLVTN--GKHGKKVNNVW 545

  Fly   488 TGMLREIMTGRADLAITDLTITSEREQALDFTIPFMNLGIAILYLKPQKATPELFTFMDPFSEEV 552
            .||:.|::..||.:|:..|||..||.:.:||::||:..||::: :.....|.....|::|||..|
Human   546 NGMIGEVVYQRAVMAVGSLTINEERSEVVDFSVPFVETGISVM-VSRSNGTVSPSAFLEPFSASV 609

  Fly   553 WWFLGFSFLGVS-LSFFILGRLSPSEWDNPYPCIEEPEELENQFTLGNSIWFTTGALLQQGSEI- 615
            |..:....|.|| ::.|:....||..::......:.|.  ...||:|.:||...|.:......:
Human   610 WVMMFVMLLIVSAIAVFVFEYFSPVGYNRNLAKGKAPH--GPSFTIGKAIWLLWGLVFNNSVPVQ 672

  Fly   616 GPKALSTRTVASFWWFFTLIVVSSYTANLAAFLTIEKPQSLINSVDDLADNK--------DGVVY 672
            .||..:::.:.|.|.||.:|.::|||||||||:..|:   .::.|..|:|.|        ....:
Human   673 NPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEE---FVDQVTGLSDKKFQRPHDYSPPFRF 734

  Fly   673 GAKKTGST-RNFFMTSAEERYKKMNKFMSENPQYLTEDNMEGVN----RVKTNTHYAFLMESTSI 732
            |....||| ||.     ...|..|:       ||:|:.|.:||.    .:||....||:.::..:
Human   735 GTVPNGSTERNI-----RNNYPYMH-------QYMTKFNQKGVEDALVSLKTGKLDAFIYDAAVL 787

  Fly   733 EYNTKRE--CNLKKIGDA--LDEKGYGIAMRKDWPHRGKFNNALLELQEQGVLEKMKNKWWNEVG 793
            .|...|:  |.|..||..  ....|||||::|..|.:.:.:.|||:....|.:|:::..|.
Human   788 NYKAGRDEGCKLVTIGSGYIFATTGYGIALQKGSPWKRQIDLALLQFVGDGEMEELETLWL---- 848

  Fly   794 TGICATKEDAPDATPLDMNNLEGVFFVLLVGSCCALL----------------YGIIS---WVLF 839
            ||||..:::...::.||::|:.|||::|......:|:                .|:.|   .:||
Human   849 TGICHNEKNEVMSSQLDIDNMAGVFYMLAAAMALSLITFIWEHLFYWKLRFCFTGVCSDRPGLLF 913

  Fly   840 VMKKA-----HHYRVPLRDALKEEFQFVIDFN------NYVRVLKNSASIYSRSRQSSMSVAS 891
            .:.:.     |...:       ||.:...|||      |.:::|:::.:|.|.|..:|..:.|
Human   914 SISRGIYSCIHGVHI-------EEKKKSPDFNLTGSQSNMLKLLRSAKNISSMSNMNSSRMDS 969

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIE	NP_001036733.1	PBP1_iGluR_Kainate	42..396	CDD:107377	81/426 (19%)
		ANF_receptor	51..382	CDD:279440	77/412 (19%)
		PBP2_iGluR_Kainate	419..790	CDD:270432	107/390 (27%)
		Lig_chan	551..824	CDD:278489	84/291 (29%)
GRIN2A	XP_016878661.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155943
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740