Protein Alignment GluRIIE and GRIK5

DIOPT Version :10

• Sequence 1: NP_001036733.1
• Gene: GluRIIE / 318623
• FlyBaseID: FBgn0051201
• Length: 897
• Species: Drosophila melanogaster
• Sequence 2: XP_011525167.1
• Gene: GRIK5 / 2901
• HGNCID: 4583
• Length: 982
• Species: Homo sapiens
• Alignment Length: 880
• Identity: 291/880 - (33%)
• Similarity: 439/880 - (49%)
• Gaps: 81/880 - (9%)

  Fly    34 QSLESVPIGLLTDQNT--------------EQMNIVFDHAIDV-ANQEVGTSLTSLKEEVNYGDA 83
            |.|.|:.:..:.|..|              ||:|.:    |:| |...|...:..|:.:    ..
Human    19 QVLSSLRMAAILDDQTVCGRGERLALALAREQINGI----IEVPAKARVEVDIFELQRD----SQ 75

  Fly    84 YQSYGKLCRMLETGIAGVFGPSSRHTAVHLMS-ICDAMDIPHIYSYMSENAE-------GFNLHP 140
            |::...:|::|..|:..|.||||...:...:| ||...:||||.....|...       ..:|:|
Human    76 YETTDTMCQILPKGVVSVLGPSSSPASASTVSHICGEKEIPHIKVGPEETPRLQYLRFASVSLYP 140

  Fly   141 HPADLAKALYSLITEFNWTRFIFLYESAEYLNILNELTTMLGKSGTVITVLRYDMQLNGNYKQVL 205
            ...|::.|:..::..||:.....:...||.|..|.||......|...::|...|...:..  .:|
Human   141 SNEDVSLAVSRILKSFNYPSASLICAKAECLLRLEELVRGFLISKETLSVRMLDDSRDPT--PLL 203

  Fly   206 RRVRKSVDNRIVVVGSSETMPEFLNQAQQVGIINEDYKYIIGNLDFHSFDLEEYKYSEANITGLR 270
            :.:|....:.|::..::......|.:|.::|:.:..||||:..:||....|:......:||.|..
Human   204 KEIRDDKVSTIIIDANASISHLILRKASELGMTSAFYKYILTTMDFPILHLDGIVEDSSNILGFS 268

  Fly   271 LFSPEKMAVKELLMKLGYPTDQDEFRNGSCPITVEMALTYDAVQLFAQTLKNL------PFKPMP 329
            :|:.......|.:..|.....::...:......:..||.:|||.:....::.|      ..||:.
Human   269 MFNTSHPFYPEFVRSLNMSWRENCEASTYLGPALSAALMFDAVHVVVSAVRELNRSQEIGVKPLA 333

  Fly   330 QNCSQRTESVRDDGSSFKNYMRTLRLTDRLLTGPIYFEG-NVRKGYHLDVIELQPSGIVKVGTWD 393
              |:  :.::...|:|..||:|.:....  |||.:.|.. ..|..|.|.::|....|..::|.|
Human   334 --CT--SANIWPHGTSLMNYLRMVEYDG--LTGRVEFNSKGQRTNYTLRILEKSRQGHREIGVW- 391

  Fly   394 EDRQYRPQRLAPTTAQFD-SVDNSLANKTFIILLSVPNKPYAQLVETYKQLEGNSQYEGYGVDLI 457
                |..:.||......| ::..:|||||.::...:.| ||......::.|.||.::||:.||::
Human   392 ----YSNRTLAMNATTLDINLSQTLANKTLVVTTILEN-PYVMRRPNFQALSGNERFEGFCVDML 451

  Fly   458 KELADKLGFNF--TFVNGGNDYGSYNKSTNES-TGMLREIMT-GRADLAITDLTITSEREQALDF 518
            :|||:.|.|.:  ..|..|. ||:  ...|.| |||:.|::. .:||||:...|||:|||:.:||
Human   452 RELAELLRFRYRLRLVEDGL-YGA--PEPNGSWTGMVGELINRQKADLAVAAFTITAEREKVIDF 513

  Fly   519 TIPFMNLGIAILYLKPQKATPELFTFMDPFSEEVWWFLGFSFLGVSLSFFILGRLSPSEWDNPYP 583
            :.|||.|||:|||.......|..|:|:||||..||.|:..::|.||...|:..||||.||.||:|
Human   514 SKPFMTLGISILYRVHMGRKPGYFSFLDPFSPAVWLFMLLAYLAVSCVLFLAARLSPYEWYNPHP 578

  Fly   584 CIE-EPEELENQFTLGNSIWFTTGALLQQGSEIGPKALSTRTVASFWWFFTLIVVSSYTANLAAF 647
            |:. .|..||||:|||||:||..|..:||||||.|:|||||.|:..||.||||::||||||||||
Human   579 CLRARPHILENQYTLGNSLWFPVGGFMQQGSEIMPRALSTRCVSGVWWAFTLIIISSYTANLAAF 643

  Fly   648 LTIEKPQSLINSVDDLADNKDGVVYGAKKTGSTRNFFMTSAEERYKKM-NKFMSENPQYLTEDNM 711
            ||:::.:..:.|.||||| :..:.||....|||..||..|..:.|::| |...|:.|....:...
Human   644 LTVQRMEVPVESADDLAD-QTNIEYGTIHAGSTMTFFQNSRYQTYQRMWNYMQSKQPSVFVKSTE 707

  Fly   712 EGVNRVKTNTHYAFLMESTSIEYNTKRECNLKKIGDALDEKGYGIAMRKDWPHRGKFNNALLELQ 776
            ||:.|| .|:.||||:|||..||:.:..|||.:||..||.|||||.|....|.|.:...|:|:||
Human   708 EGIARV-LNSRYAFLLESTMNEYHRRLNCNLTQIGGLLDTKGYGIGMPLGSPFRDEITLAILQLQ 771

  Fly   777 EQGVLEKMKNKWWNEVGTGICATKEDAPDATPLDMNNLEGVFFVLLVGSCCALLYGIISWVLFVM 841
            |...||.:|.|||.   .|.|..:|| ..|..|.|.|:.|:|.||:.|...|:...::.::....
Human   772 ENNRLEILKRKWWE---GGRCPKEED-HRAKGLGMENIGGIFIVLICGLIIAVFVAVMEFIWSTR 832

  Fly   842 KKAHHYRVPL-------------RDALKEEFQFVI 863
            :.|.....|.             |..|||....::
Human   833 RSAESEETPALHPAACQCSALGPRTPLKEPSMLLV 867

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIE	NP_001036733.1	PBP1_iGluR_Kainate	40..402	CDD:380605	87/391 (22%)
		PBP2_iGluR_Kainate	419..790	CDD:270432	175/376 (47%)
		Lig_chan	551..824	CDD:459656	132/274 (48%)
GRIK5	XP_011525167.1	PBP1_iGluR_Kainate_KA1_2	23..401	CDD:380616	90/398 (23%)
		Periplasmic_Binding_Protein_Type_2	414..785	CDD:473866	175/376 (47%)