DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment GluRIIE and GRIK4

DIOPT Version :9

Sequence 1:NP_001036733.1 Gene:GluRIIE / 318623 FlyBaseID:FBgn0051201 Length:897 Species:Drosophila melanogaster
Sequence 2:NP_001269399.1 Gene:GRIK4 / 2900 HGNCID:4582 Length:956 Species:Homo sapiens


Alignment Length:901 Identity:286/901 - (31%)
Similarity:455/901 - (50%) Gaps:88/901 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly    38 SVPIGLL--------TDQNTEQMNIVFDHAIDVANQEVGTSLTSLKEEVN-----YGDA------ 83
            |.|:.||        ...::.::..:.|..::.:..| ..|:|..|..:|     .|.|      
Human     5 SAPLVLLPAWLVMVACSPHSLRIAAILDDPMECSRGE-RLSITLAKNRINRAPERLGKAKVEVDI 68

  Fly    84 --------YQSYGKLCRMLETGIAGVFGPSSRHTAVHLMS-ICDAMDIPH-------IYSYMSEN 132
                    |::...:|::|..|:..|.||||...:..::| ||...::||       ...:..:.
Human    69 FELLRDSEYETAETMCQILPKGVVAVLGPSSSPASSSIISNICGEKEVPHFKVAPEEFVKFQFQR 133

  Fly   133 AEGFNLHPHPADLAKALYSLITEFNWTRFIFLYESAEYLNILNELTTMLGKSGTVITVLRYDMQL 197
            ....||||...|::.|:..::..||.|....:...||.|..|.:|......|...::|...|...
Human   134 FTTLNLHPSNTDISVAVAGILNFFNCTTACLICAKAECLLNLEKLLRQFLISKDTLSVRMLDDTR 198

  Fly   198 NGNYKQVLRRVRKSVDNRIVVVGSSETMPEFLNQAQQVGIINEDYKYIIGNLDFHSFDLEEYKYS 262
            :..  .:|:.:|......|::..::......|.:|.::|:::..|.||..||:|....::.....
Human   199 DPT--PLLKEIRDDKTATIIIHANASMSHTILLKAAELGMVSAYYTYIFTNLEFSLQRMDSLVDD 261

  Fly   263 EANITGLRLFSPEKMAVKELLMKLGYPTDQDEFRNGSC---PIT---VEMALTYDAVQLFAQTLK 321
            ..||.|..:|:......:|....|.....:      :|   |.|   :..||.:|||......::
Human   262 RVNILGFSIFNQSHAFFQEFAQSLNQSWQE------NCDHVPFTGPALSSALLFDAVYAVVTAVQ 320

  Fly   322 NL------PFKPMPQNCSQRTESVRDDGSSFKNYMRTLRLTDRLLTGPIYFEG-NVRKGYHLDVI 379
            .|      ..||:....:|    :...|:|..||:|.:.|..  |||.|.|.. ..|..|.|.::
Human   321 ELNRSQEIGVKPLSCGSAQ----IWQHGTSLMNYLRMVELEG--LTGHIEFNSKGQRSNYALKIL 379

  Fly   380 ELQPSGIVKVGTWDEDRQYRPQRLAPTTAQFDS-VDNSLANKTFIILLSVPNKPYAQLVETYKQL 443
            :...:|..::|.|     :..:.|:..:..:.| :.::|.|.|.::...:.| ||..|...::::
Human   380 QFTRNGFRQIGQW-----HVAEGLSMDSHLYASNISDTLFNTTLVVTTILEN-PYLMLKGNHQEM 438

  Fly   444 EGNSQYEGYGVDLIKELADKLGFNFTFVNGGNDYGSYNKSTNESTGMLREIMTGRADLAITDLTI 508
            |||.:|||:.||::||||:.|.||:.....|:......::....|||:.|::..:||||:..|||
Human   439 EGNDRYEGFCVDMLKELAEILRFNYKIRLVGDGVYGVPEANGTWTGMVGELIARKADLAVAGLTI 503

  Fly   509 TSEREQALDFTIPFMNLGIAILYLKPQKATPELFTFMDPFSEEVWWFLGFSFLGVSLSFFILGRL 573
            |:|||:.:||:.|||.|||:|||.......|..|:|:||||..||.|:..::|.||...|::.||
Human   504 TAEREKVIDFSKPFMTLGISILYRVHMGRKPGYFSFLDPFSPGVWLFMLLAYLAVSCVLFLVARL 568

  Fly   574 SPSEWDNPYPCIE-EPEELENQFTLGNSIWFTTGALLQQGSEIGPKALSTRTVASFWWFFTLIVV 637
            :|.||.:|:||.: ....|.||::||||:||..|..:||||.|.|:|||||.|:..||.||||::
Human   569 TPYEWYSPHPCAQGRCNLLVNQYSLGNSLWFPVGGFMQQGSTIAPRALSTRCVSGVWWAFTLIII 633

  Fly   638 SSYTANLAAFLTIEKPQSLINSVDDLADNKDGVVYGAKKTGSTRNFFMTSAEERYKKMNKFM-SE 701
            ||||||||||||:::....|.||||||| :..:.||....||:..||..|..:.|::|..:| |:
Human   634 SSYTANLAAFLTVQRMDVPIESVDDLAD-QTAIEYGTIHGGSSMTFFQNSRYQTYQRMWNYMYSK 697

  Fly   702 NPQYLTEDNMEGVNRVKTNTHYAFLMESTSIEYNTKRECNLKKIGDALDEKGYGIAMRKDWPHRG 766
            .|....:...||:.|| .|::||||:|||..||..:|.|||.:||..||.|||||.|......|.
Human   698 QPSVFVKSTEEGIARV-LNSNYAFLLESTMNEYYRQRNCNLTQIGGLLDTKGYGIGMPVGSVFRD 761

  Fly   767 KFNNALLELQEQGVLEKMKNKWWNEVGTGICATKEDAPDATPLDMNNLEGVFFVLLVGSCCALLY 831
            :|:.|:|:|||...||.:|.|||.   .|.|..:|| ..|..|.|.|:.|:|.||:.|...|:..
Human   762 EFDLAILQLQENNRLEILKRKWWE---GGKCPKEED-HRAKGLGMENIGGIFVVLICGLIVAIFM 822

  Fly   832 GIISWVLFVMKKAHHYRVPLRDALKEEFQFVIDFNNYVRVLKNSASIYSRSRQSSM 887
            .::.: |:.::.:....|.:...:..|.:.:|...:         ||:.|.|::::
Human   823 AMLEF-LWTLRHSEATEVSVCQEMVTELRSIILCQD---------SIHPRRRRAAV 868

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GluRIIENP_001036733.1 PBP1_iGluR_Kainate 42..396 CDD:107377 88/401 (22%)
ANF_receptor 51..382 CDD:279440 83/370 (22%)
PBP2_iGluR_Kainate 419..790 CDD:270432 170/372 (46%)
Lig_chan 551..824 CDD:278489 128/274 (47%)
GRIK4NP_001269399.1 PBP1_iGluR_Kainate_KA1_2 26..400 CDD:107389 87/393 (22%)
ANF_receptor 43..382 CDD:279440 81/352 (23%)
PBP2_iGluR_kainate_KA1 415..785 CDD:270442 170/372 (46%)
Lig_chan 547..816 CDD:278489 128/274 (47%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 863..889 1/6 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 931..956
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165155764
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1052
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG60082
OrthoDB 1 1.010 - - D60688at33208
OrthoFinder 1 1.000 - - FOG0000021
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100167
Panther 1 1.100 - - O PTHR18966
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
98.760

Return to query results.
Submit another query.