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Protein Alignment GluRIIE and GRIK2

DIOPT Version :9

Sequence 1:	NP_001036733.1	Gene:	GluRIIE / 318623	FlyBaseID:	FBgn0051201	Length:	897	Species:	Drosophila melanogaster
Sequence 2:	NP_068775.1	Gene:	GRIK2 / 2898	HGNCID:	4580	Length:	908	Species:	Homo sapiens

Alignment Length:	890	Identity:	314/890 - (35%)
Similarity:	486/890 - (54%)	Gaps:	83/890 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 ILWSLFSIHISVNWAQYENFGGYDNYQSLESVPIGLLTDQNTEQMNIVFDHAIDVANQE----VG 68
            :||    |..|........|||...|  :||.|:|      .|:  :.|..|::..|:.    ..
Human    23 LLW----IGYSQGTTHVLRFGGIFEY--VESGPMG------AEE--LAFRFAVNTINRNRTLLPN 73

  Fly    69 TSLTSLKEEVNYGDAYQSYGKLCRMLETGIAGVFGPSSRHTAVHLMSICDAMDIPHIYS----YM 129
            |:||...:::|..|::::..|.|..|..|:|.:||||...:|..:.|||:|:.:|||.:    .:
Human    74 TTLTYDTQKINLYDSFEASKKACDQLSLGVAAIFGPSHSSSANAVQSICNALGVPHIQTRWKHQV 138

  Fly   130 SENAEGF--NLHPHPADLAKALYSLITEFNWTRFIFLYESAEYLNILNELTTMLGKSGTVITVLR 192
            |:|.:.|  :|:|..:.|::|:..|:..|.|.....:|:.:..|..|.||         :....|
Human   139 SDNKDSFYVSLYPDFSSLSRAILDLVQFFKWKTVTVVYDDSTGLIRLQEL---------IKAPSR 194

  Fly   193 YDMQL--------NGNYKQVLRRVRKSVDNRIVVVGSSETMPEFLNQAQQVGIINEDYKYIIGNL 249
            |:::|        ..:.|.:|:.:::..:..::...|.|.....|.||..:|::.|.|.||...|
Human   195 YNLRLKIRQLPADTKDAKPLLKEMKRGKEFHVIFDCSHEMAAGILKQALAMGMMTEYYHYIFTTL 259

  Fly   250 DFHSFDLEEYKYSEANITGLRLFSPEKMAVKELLMK-----LGYPTDQDE-FRNGSCPITVEMAL 308
            |..:.|:|.|:||..|:||.|:.:.|...|..::.|     |..|...|. ..:|.  :|.:.||
Human   260 DLFALDVEPYRYSGVNMTGFRILNTENTQVSSIIEKWSMERLQAPPKPDSGLLDGF--MTTDAAL 322

  Fly   309 TYDAVQLFAQTLKNLPFKPMPQNCSQRTESVRDDGSSFKNYMRTLRLTDRLLTGPIYFE--GNVR 371
            .||||.:.:..::..|...:......|.:..| .|:.|.:.::......  |||.|.|.  ..:|
Human   323 MYDAVHVVSVAVQQFPQMTVSSLQCNRHKPWR-FGTRFMSLIKEAHWEG--LTGRITFNKTNGLR 384

  Fly   372 KGYHLDVIELQPSGIVKVGTWD--------EDRQYRPQRLAPTTAQFDSVDNSLANKTFIILLSV 428
            ..:.||||.|:..|:.|:||||        |.::.:|.          ::.:||:|:: :|:.::
Human   385 TDFDLDVISLKEEGLEKIGTWDPASGLNMTESQKGKPA----------NITDSLSNRS-LIVTTI 438

  Fly   429 PNKPYAQLVETYKQLEGNSQYEGYGVDLIKELADKLGFNF--TFVNGGNDYGSYNKSTNESTGML 491
            ..:||....::.|.|.||.::|||.:||::||:..|||.:  ..|..|. ||:.:.:..:..||:
Human   439 LEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYEIRLVEDGK-YGAQDDANGQWNGMV 502

  Fly   492 REIMTGRADLAITDLTITSEREQALDFTIPFMNLGIAILYLKPQKATPELFTFMDPFSEEVWWFL 556
            ||::..:||||:..|.||..||:.:||:.|||.|||:|||.||....|.:|:|::|.|.::|.::
Human   503 RELIDHKADLAVAPLAITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLSPDIWMYI 567

  Fly   557 GFSFLGVSLSFFILGRLSPSEWDNPYPCIEEPEELENQFTLGNSIWFTTGALLQQGSEIGPKALS 621
            ..::||||...|::.|.||.||.||:||..:.:.:||.|||.||.||..|||:|||||:.|||||
Human   568 LLAYLGVSCVLFVIARFSPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSELMPKALS 632

  Fly   622 TRTVASFWWFFTLIVVSSYTANLAAFLTIEKPQSLINSVDDLADNKDGVVYGAKKTGSTRNFFMT 686
            ||.|...|||||||::||||||||||||:|:.:|.|:|.|||| .:..:.|||.:.|:|..||..
Human   633 TRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLA-KQTKIEYGAVEDGATMTFFKK 696

  Fly   687 SAEERYKKMNKFMSENPQ-YLTEDNMEGVNRVKTNTHYAFLMESTSIEYNTKRECNLKKIGDALD 750
            |....|.||..|||...| .|.:.|.||:.||.| :.||||||||:||:.|:|.|||.:||..:|
Human   697 SKISTYDKMWAFMSSRRQSVLVKSNEEGIQRVLT-SDYAFLMESTTIEFVTQRNCNLTQIGGLID 760

  Fly   751 EKGYGIAMRKDWPHRGKFNNALLELQEQGVLEKMKNKWWNEVGTGICATKEDAPDATPLDMNNLE 815
            .||||:......|:|.|...|:|:|||:|.|..||.|||.  |.|  ..:|::.:|:.|.:.|:.
Human   761 SKGYGVGTPMGSPYRDKITIAILQLQEEGKLHMMKEKWWR--GNG--CPEEESKEASALGVQNIG 821

  Fly   816 GVFFVLLVGSCCALLYGIISWVLFVMKKAHHYRVPLRDALKEEFQ 860
            |:|.||..|...::...:..::....|.|...:.....|:.||.:
Human   822 GIFIVLAAGLVLSVFVAVGEFLYKSKKNAQLEKRSFCSAMVEELR 866

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.