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Protein Alignment GluRIIE and GRIK1

DIOPT Version :9

Sequence 1:	NP_001036733.1	Gene:	GluRIIE / 318623	FlyBaseID:	FBgn0051201	Length:	897	Species:	Drosophila melanogaster
Sequence 2:	NP_001317923.1	Gene:	GRIK1 / 2897	HGNCID:	4579	Length:	949	Species:	Homo sapiens

Alignment Length:	960	Identity:	333/960 - (34%)
Similarity:	496/960 - (51%)	Gaps:	130/960 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 WSL--FSIHISVNWA-QYENFGGYDNYQSLESVPIGLLTDQNTEQMNIVFDHAIDVANQE----V 67
            |:|  |..:|....| |....||.  ::::|:.|:      |.|:  :.|..|:...|:.    .
Human    19 WALLYFLCYILPQTAPQVLRIGGI--FETVENEPV------NVEE--LAFKFAVTSINRNRTLMP 73

  Fly    68 GTSLTSLKEEVNYGDAYQSYGKLCRMLETGIAGVFGPSSRHTAVHLMSICDAMDIPHIYSYMS-- 130
            .|:||...:.:|..|::::..:.|..|..|:|.:||||...:...:.|||:|:::|||.:...
Human    74 NTTLTYDIQRINLFDSFEASRRACDQLALGVAALFGPSHSSSVSAVQSICNALEVPHIQTRWKHP 138

  Fly   131 --ENAEGF--NLHPHPADLAKALYSLITEFNWTRFIFLYESAEYLNILNELTTMLGKSGTVITVL 191
              :|.:.|  ||:|..|.:::|:..|:..:||.....:||.:..|..|.||         :....
Human   139 SVDNKDLFYINLYPDYAAISRAILDLVLYYNWKTVTVVYEDSTGLIRLQEL---------IKAPS 194

  Fly   192 RYDMQL--------NGNYKQVLRRVRKSVDNRIVVVGSSETMPEFLNQAQQVGIINEDYKYIIGN 248
            ||::::        |.:.|.:|:.::|..:..::...|.||..|.|.|...:|::.|.|.|....
Human   195 RYNIKIKIRQLPSGNKDAKPLLKEMKKGKEFYVIFDCSHETAAEILKQILFMGMMTEYYHYFFTT 259

  Fly   249 LDFHSFDLEEYKYSEANITGLRLFSPEKMAVKELLMKLGY------PTDQDEFRNGSCPITVEMA 307
            ||..:.|||.|:||..|:||.||.:.:...|..::.|...      |..:....:|.  :|.|.|
Human   260 LDLFALDLELYRYSGVNMTGFRLLNIDNPHVSSIIEKWSMERLQAPPRPETGLLDGM--MTTEAA 322

  Fly   308 LTYDAV-----------QLFAQTLKNLPFKPMPQNCSQRTESVRDDGSSFKNYMRTLRLTDRLLT 361
            |.||||           ||...:|:....||...            |..|.|.::..|...  ||
Human   323 LMYDAVYMVAIASHRASQLTVSSLQCHRHKPWRL------------GPRFMNLIKEARWDG--LT 373

  Fly   362 GPIYFE--GNVRKGYHLDVIELQPSGI---------------VKVGTWDEDRQYRPQRLAPTTAQ 409
            |.|.|.  ..:||.:.||:|.|:..|.               .|:|.|:.:     ..|..|.:.
Human   374 GHITFNKTNGLRKDFDLDIISLKEEGTEKAAGEVSKHLYKVWKKIGIWNSN-----SGLNMTDSN 433

  Fly   410 FD---SVDNSLANKTFIILLSVPNKPYAQLVETYKQLEGNSQYEGYGVDLIKELADKLGF--NFT 469
            .|   ::.:||||:| :|:.::..:||....::.|.|.||.::|||.:||:|||::.|||  :..
Human   434 KDKSSNITDSLANRT-LIVTTILEEPYVMYRKSDKPLYGNDRFEGYCLDLLKELSNILGFIYDVK 497

  Fly   470 FVNGGNDYGSYNKSTNESTGMLREIMTGRADLAITDLTITSEREQALDFTIPFMNLGIAILYLKP 534
            .|..|. ||:.| ...|..||::|::..|||||:..||||..||:.:||:.|||.|||:|||.||
Human   498 LVPDGK-YGAQN-DKGEWNGMVKELIDHRADLAVAPLTITYVREKVIDFSKPFMTLGISILYRKP 560

  Fly   535 QKATPELFTFMDPFSEEVWWFLGFSFLGVSLSFFILGRLSPSEWDNPYPCIEEPEELENQFTLGN 599
            ....|.:|:|::|.|.::|.::..:.||||...|::.|.:|.||.||:||..:.:.:||.|||.|
Human   561 NGTNPGVFSFLNPLSPDIWMYVLLACLGVSCVLFVIARFTPYEWYNPHPCNPDSDVVENNFTLLN 625

  Fly   600 SIWFTTGALLQQGSEIGPKALSTRTVASFWWFFTLIVVSSYTANLAAFLTIEKPQSLINSVDDLA 664
            |.||..|||:|||||:.|||||||.|...|||||||::||||||||||||:|:.:|.|:|.||||
Human   626 SFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLA 690

  Fly   665 DNKDGVVYGAKKTGSTRNFFMTSAEERYKKMNKFMSENPQ-YLTEDNMEGVNRVKTNTHYAFLME 728
             .:..:.|||.:.|||..||..|....|:||..|||...| .|..::.||:.||.| |.||.|||
Human   691 -KQTKIEYGAVRDGSTMTFFKKSKISTYEKMWAFMSSRQQTALVRNSDEGIQRVLT-TDYALLME 753

  Fly   729 STSIEYNTKRECNLKKIGDALDEKGYGIAMRKDWPHRGKFNNALLELQEQGVLEKMKNKWWNEVG 793
            ||||||.|:|.|||.:||..:|.||||:......|:|.|...|:|:|||:|.|..||.|||.  |
Human   754 STSIEYVTQRNCNLTQIGGLIDSKGYGVGTPIGSPYRDKITIAILQLQEEGKLHMMKEKWWR--G 816

  Fly   794 TGICATKEDAPDATPLDMNNLEGVFFVLLVGSCCALLYGIISWVLFVMK--------KAHHYRVP 850
            .|  ..:||..:|:.|.:.|:.|:|.||..|...::...|..::....|        |:...|..
Human   817 NG--CPEEDNKEASALGVENIGGIFIVLAAGLVLSVFVAIGEFIYKSRKNNDIEQKGKSSRIRFY 879

  Fly   851 LRDALKEE--------FQFVIDFNNYVR----VLKNSASIYSRSRQSSMS 888
            .|:.::..        .:..:.||..:.    .|||...|..:||....|
Human   880 FRNKVRFHGRKKQSLGVEKCLSFNAIMEELGISLKNQKKIKKKSRTKGKS 929

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.