Protein Alignment GluRIIE and GRID1

DIOPT Version :10

• Sequence 1: NP_001036733.1
• Gene: GluRIIE / 318623
• FlyBaseID: FBgn0051201
• Length: 897
• Species: Drosophila melanogaster
• Sequence 2: NP_060021.1
• Gene: GRID1 / 2894
• HGNCID: 4575
• Length: 1009
• Species: Homo sapiens
• Alignment Length: 908
• Identity: 227/908 - (25%)
• Similarity: 400/908 - (44%)
• Gaps: 156/908 - (17%)

  Fly    39 VPIGLLTDQNTEQMNIVFDHAI-------DVANQEVGTSLTSLKEEVNYGDAYQSYGKLCRMLET 96
            :.||.:.::|..:.:.||..|:       |:...|   .:|...:.:...:.:|:..:.|.::..
Human    24 IHIGAIFEENAAKDDRVFQLAVSDLSLNDDILQSE---KITYSIKVIEANNPFQAVQEACDLMTQ 85

  Fly    97 GIAGVFGPSSRHTAVHLMSICDAMDIPHIYSYMSENAEG-----FNLHPHPADLAKALYS----- 151
            ||..:...:...:|..|.|:.|||.|||:  ::..|..|     .:|:|.|...|..|.|
Human    86 GILALVTSTGCASANALQSLTDAMHIPHL--FVQRNPGGSPRTACHLNPSPDGEAYTLASRPPVR 148

  Fly   152 -------LITEFNWTRFIFLYESAEYLNILNELTTMLGKSGTVITVLRYDMQLNGNYKQV----- 204
                   |:||..|.:|:..|:|...:..|........:.|..:::.:.|..::..:..:
Human   149 LNDVMLRLVTELRWQKFVMFYDSEYDIRGLQSFLDQASRLGLDVSLQKVDKNISHVFTSLFTTMK 213

  Fly   205 ---LRRVRKSVDNRIVVVGSSETMPEFLNQAQQVGIINEDYKYIIGNLDFHSFDLEEYKYSEANI 266
               |.|.|.:: .|.:::.|.:....|:|:|.:..:.::|..::..|        ||  .|:..|
Human   214 TEELNRYRDTL-RRAILLLSPQGAHSFINEAVETNLASKDSHWVFVN--------EE--ISDPEI 267

  Fly   267 TGLRLFSPEKMAVKELLMKLGYPTDQDEFRNGSCP--------------------ITVEMALTYD 311
            ..|...:..:|.|...:    :|:.:|   |..|.                    :.:.....||
Human   268 LDLVHSALGRMTVVRQI----FPSAKD---NQKCTRNNHRISSLLCDPQEGYLQMLQISNLYLYD 325

  Fly   312 AVQL----FAQTLKNLPFKPMPQ-NCSQRTESVRDDGSSFKNYMRTLRLTDRLLTGPIYFEGNVR 371
            :|.:    |.:.|::..:..|.. ||.:::....:.|.|..:.::...:|.  |||.:.|..:..
Human   326 SVLMLANAFHRKLEDRKWHSMASLNCIRKSTKPWNGGRSMLDTIKKGHITG--LTGVMEFREDSS 388

  Fly   372 KGY-HLDVI-----ELQPSGIVKVGTWDEDR------QYRP--QRLAPTTAQFDSVDNSLANKTF 422
            ..| ..:::     |.....:.|:.|||.::      |.||  .||...|.:
Human   389 NPYVQFEILGTTYSETFGKDMRKLATWDSEKGLNGSLQERPMGSRLQGLTLK------------- 440

  Fly   423 IILLSVPNKPYAQLVETYKQLEGNSQYEGYGVDLIKELADKLGFNFTFVNGGND-YGS--YNKST 484
              :::|..:|:..:.|..  |....:|:|:.:|::..||..|||.:......:. ||.  :|.|.
Human   441 --VVTVLEEPFVMVAENI--LGQPKRYKGFSIDVLDALAKALGFKYEIYQAPDGRYGHQLHNTSW 501

  Fly   485 NESTGMLREIMTGRADLAITDLTITSEREQALDFTIPFMNLGIAILYLKPQKATPELFTFMDPFS 549
            |   ||:.|:::.||||||:.:|||.|||..:||:..:|:..:.||..||::.. .:|:...||.
Human   502 N---GMIGELISKRADLAISAITITPERESVVDFSKRYMDYSVGILIKKPEEKI-SIFSLFAPFD 562

  Fly   550 EEVWWFLGFSFLGVSLSFFILGRLSPSEWDN---PYPCIEEPEELENQFTLGNSIWFTTGALLQQ 611
            ..||..:..:...|.:..|:|.|:......:   |.|....        ||.::||...||.:||
Human   563 FAVWACIAAAIPVVGVLIFVLNRIQAVRAQSAAQPRPSASA--------TLHSAIWIVYGAFVQQ 619

  Fly   612 GSEIGPKALSTRTVASFWWFFTLIVVSSYTANLAAFLTIEKPQSLINSVDDLADNKDGVVYGAKK 676
            |.|....:::.|.|...||.|||||.||||||||||||:.:..:.|.:..||:...: :.||..:
Human   620 GGESSVNSMAMRIVMGSWWLFTLIVCSSYTANLAAFLTVSRMDNPIRTFQDLSKQVE-MSYGTVR 683

  Fly   677 TGSTRNFFMTSA------EERYKKMNKFMSENPQYLTEDN-----MEGVNRVKTNTHYAFLMEST 730
            ..:...:|....      :..:.::.:.:|:|.   ..||     .||:.:.|.. :||||.:..
Human   684 DSAVYEYFRAKGTNPLEQDSTFAELWRTISKNG---GADNCVSSPSEGIRKAKKG-NYAFLWDVA 744

  Fly   731 SIEYN--TKRECNLKKIGDALDEKGYGIAMRKDWPHRGKFNNALLELQEQGVLEKMKNKWWNEVG 793
            .:||.  |..:|::..||:::..||||||::...|:|..|:..:||||:.|.|:.:|.|||..:|
Human   745 VVEYAALTDDDCSVTVIGNSISSKGYGIALQHGSPYRDLFSQRILELQDTGDLDVLKQKWWPHMG 809

  Fly   794 TGICATKEDA---PDATPLDMNNLEGVFFVLLVGSCCALLYGIISWVLFVMKKAHHYRVPLRD 853
            .  |.....|   .|...|.:::..|||.:|.:|...|.|...:.  |:......|...|..|
Human   810 R--CDLTSHASAQADGKSLKLHSFAGVFCILAIGLLLACLVAALE--LWWNSNRCHQETPKED 868

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIE	NP_001036733.1	PBP1_iGluR_Kainate	40..402	CDD:380605	85/432 (20%)
		PBP2_iGluR_Kainate	419..790	CDD:270432	122/389 (31%)
		Lig_chan	551..824	CDD:459656	90/291 (31%)
GRID1	NP_060021.1	Interaction with CBLN1. /evidence=ECO:0000250|UniProtKB:Q61627	21..436		87/436 (20%)
		PBP1_iGluR_delta_1	25..425	CDD:380615	82/424 (19%)
		PBP2_iGluR_delta_1	436..806	CDD:270448	123/403 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	930..954