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Protein Alignment GluRIIE and GRIA4

DIOPT Version :9

Sequence 1:	NP_001036733.1	Gene:	GluRIIE / 318623	FlyBaseID:	FBgn0051201	Length:	897	Species:	Drosophila melanogaster
Sequence 2:	NP_000820.4	Gene:	GRIA4 / 2893	HGNCID:	4574	Length:	902	Species:	Homo sapiens

Alignment Length:	859	Identity:	294/859 - (34%)
Similarity:	459/859 - (53%)	Gaps:	54/859 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 SVPIGLLTDQNTEQMNIVFDHAIDVAN-----QEVGTSLTSLKEEVNYGDAYQSYGKLCRMLETG 97
            ||.||.|..:||:|....|..||.:.|     .|...:|....:.:...:::......|.....|
Human    26 SVQIGGLFIRNTDQEYTAFRLAIFLHNTSPNASEAPFNLVPHVDNIETANSFAVTNAFCSQYSRG 90

  Fly    98 IAGVFGPSSRHTAVHLMSICDAMDIPHIY-SYMSENAEGFNLHPHPADLAKALYSLITEFNWTRF 161
            :..:||...:.:...|.|.|.|:.|..|. |:.:|....|.|...|: |..||.||:..:.|..|
Human    91 VFAIFGLYDKRSVHTLTSFCSALHISLITPSFPTEGESQFVLQLRPS-LRGALLSLLDHYEWNCF 154

  Fly   162 IFLYESAEYLNILNELTTMLGKSGTVITVLRYDMQLNGNYKQVLRRVRKSVDNRIVVVGSSETMP 226
            :|||::....:||..:....|::|..::.:..:...:.:|:|:|..:.:..:.:.|:....|.:.
Human   155 VFLYDTDRGYSILQAIMEKAGQNGWHVSAICVENFNDVSYRQLLEELDRRQEKKFVIDCEIERLQ 219

  Fly   227 EFLNQAQQVGIINEDYKYIIGNLDFHSFDLEEYKYSEANITGLRLF---SPEKMAVKELLMKLGY 288
            ..|.|...||...:.|.|||.||.|....||.:.:..||:||.:|.   :|  |.:|  ||....
Human   220 NILEQIVSVGKHVKGYHYIIANLGFKDISLERFIHGGANVTGFQLVDFNTP--MVIK--LMDRWK 280

  Fly   289 PTDQDEFRNGSCPITVEMALTYDAVQLFAQTLKNLPFKPM-------PQNCSQRTESVRDDGSSF 346
            ..||.|:.....|.....|||||.|.:.|:|.::|..:.:       ..:|.....:....|...
Human   281 KLDQREYPGSETPPKYTSALTYDGVLVMAETFRSLRRQKIDISRRGNAGDCLANPAAPWGQGIDM 345

  Fly   347 KNYMRTLRLTDRLLTGPIYFEGNVRK-GYHLDVIELQPSGIVKVGTW-DEDRQYRPQRLAPTTAQ 409
            :..::.:|:..  |||.:.|:...|: .|.:||.||:.:|..|||.| |.|:....|.: ||...
Human   346 ERTLKQVRIQG--LTGNVQFDHYGRRVNYTMDVFELKSTGPRKVGYWNDMDKLVLIQDV-PTLGN 407

  Fly   410 FDSVDNSLANKTFIILLSVPNKPYAQLVETYKQLEGNSQYEGYGVDLIKELADKLG--FNFTFVN 472
             |:.  ::.|:| :::.::...||....:.::..|||.:||||.|||..|:|..:|  :....|.
Human   408 -DTA--AIENRT-VVVTTIMESPYVMYKKNHEMFEGNDKYEGYCVDLASEIAKHIGIKYKIAIVP 468

  Fly   473 GGNDYGSYNKSTNESTGMLREIMTGRADLAITDLTITSEREQALDFTIPFMNLGIAILYLKPQKA 537
            .|. ||:.:..|....||:.|::.|:|::||..||||..||:.:||:.|||:|||:|:..||||:
Human   469 DGK-YGARDADTKIWNGMVGELVYGKAEIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKS 532

  Fly   538 TPELFTFMDPFSEEVWWFLGFSFLGVSLSFFILGRLSPSEWDNPYPCIEEPEELE--------NQ 594
            .|.:|:|:||.:.|:|..:.|:::|||:..|::.|.||.||..     ||||:.:        |:
Human   533 KPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHT-----EEPEDGKEGPSDQPPNE 592

  Fly   595 FTLGNSIWFTTGALLQQGSEIGPKALSTRTVASFWWFFTLIVVSSYTANLAAFLTIEKPQSLINS 659
            |.:.||:||:.||.:|||.:|.|::||.|.|...|||||||::||||||||||||:|:..|.|.|
Human   593 FGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIES 657

  Fly   660 VDDLADNKDGVVYGAKKTGSTRNFFMTSAEERYKKMNKFM-SENPQYLTEDNMEGVNRV-KTNTH 722
            .:|||...: :.||...:|||:.||..|....|:||..:| |..|...|....|||.|| |:...
Human   658 AEDLAKQTE-IAYGTLDSGSTKEFFRRSKIAVYEKMWTYMRSAEPSVFTRTTAEGVARVRKSKGK 721

  Fly   723 YAFLMESTSIEYNTKRE-CNLKKIGDALDEKGYGIAMRKDWPHRGKFNNALLELQEQGVLEKMKN 786
            :|||:|||..||..:|: |:..|:|..||.||||:|..|....|...|.|:|:|.|.|||:|:||
Human   722 FAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSSLRTPVNLAVLKLSEAGVLDKLKN 786

  Fly   787 KWWNEVGTGICATKED-APDAT-PLDMNNLEGVFFVLLVGSCCALLYGIISWVLFVMKKAHHYRV 849
            |||.:.|.  |..|:. :.|.| .|.::|:.|||::|:.|...|:|..:|.:......:|...::
Human   787 KWWYDKGE--CGPKDSGSKDKTSALSLSNVAGVFYILVGGLGLAMLVALIEFCYKSRAEAKRMKL 849

  Fly   850 PLRDALKEEFQFVI 863
            ...:|::.:.:..|
Human   850 TFSEAIRNKARLSI 863

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.