DRSC/TRiP Functional Genomics Resources

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Protein Alignment GluRIIE and GRIA3

DIOPT Version :9

Sequence 1:NP_001036733.1 Gene:GluRIIE / 318623 FlyBaseID:FBgn0051201 Length:897 Species:Drosophila melanogaster
Sequence 2:NP_000819.4 Gene:GRIA3 / 2892 HGNCID:4573 Length:894 Species:Homo sapiens


Alignment Length:876 Identity:293/876 - (33%)
Similarity:459/876 - (52%) Gaps:91/876 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 FVILWSLFSIHISVNWAQYENFGGYDNYQSLESVPIGLLTDQNTEQMNIVFDHAIDV--ANQEVG 68
            |::|..|...|           ||:.|     ::.||.|..:||.|.:..|..|:.:  .||...
Human    17 FLVLGLLGHSH-----------GGFPN-----TISIGGLFMRNTVQEHSAFRFAVQLYNTNQNTT 65

  Fly    69 TSLTSLKEEVNYGDAYQSY---GKLCRMLETGIAGVFGPSSRHTAVHLMSICDAMDIPHIY-SYM 129
            .....|...|::.|:..|:   ...|.....|:..:||...:.:...|.|.|.|:....:. |:.
Human    66 EKPFHLNYHVDHLDSSNSFSVTNAFCSQFSRGVYAIFGFYDQMSMNTLTSFCGALHTSFVTPSFP 130

  Fly   130 SENAEGFNLHPHPADLAKALYSLITEFNWTRFIFLYESAEYLNILNELTTMLGKSGTVITVLRYD 194
            ::....|.:...|| |..|:.||:..:.|.:|::||::....:||..:.....::...:|.    
Human   131 TDADVQFVIQMRPA-LKGAILSLLGHYKWEKFVYLYDTERGFSILQAIMEAAVQNNWQVTA---- 190

  Fly   195 MQLNGNYKQV--LRRVRKSVD----NRIVVVGSSETMPEFLNQAQQVGIINEDYKYIIGNLDFHS 253
             :..||.|.|  .||:.:.:|    .|.::....|.:...|.|...:|..:..|.|::.||.|..
Human   191 -RSVGNIKDVQEFRRIIEEMDRRQEKRYLIDCEVERINTILEQVVILGKHSRGYHYMLANLGFTD 254

  Fly   254 FDLEEYKYSEANITGLRLFSPEKMAVKELLMKLGYPTDQDEFRNG-SCPITVEMALTYDAVQLFA 317
            ..||...:..|||||.::.:.|...|::.:.: ....|:.||... :.|:....|||:||:.:.|
Human   255 ILLERVMHGGANITGFQIVNNENPMVQQFIQR-WVRLDEREFPEAKNAPLKYTSALTHDAILVIA 318

  Fly   318 QTLKNLPFKPMPQNCSQRTESVR--DDGSSFKN----------YMRTLRLTD-RLLTGPIYFEGN 369
            :..:.|.        .||.:..|  ..|....|          ..|.|::.. :.:||.|.|:..
Human   319 EAFRYLR--------RQRVDVSRRGSAGDCLANPAVPWSQGIDIERALKMVQVQGMTGNIQFDTY 375

  Fly   370 VRK-GYHLDVIELQPSGIVKVGTWDEDRQYRPQRLAPTTAQFDSVDNSLANKTFIILLSVPNKPY 433
            .|: .|.:||.|::.||..|.|.|:|   |  :|..|.:.|..|.|::.:....|::.::...||
Human   376 GRRTNYTIDVYEMKVSGSRKAGYWNE---Y--ERFVPFSDQQISNDSASSENRTIVVTTILESPY 435

  Fly   434 AQLVETYKQLEGNSQYEGYGVDLIKELAD--KLGFNFTFVNGGNDYGSYNKSTNESTGMLREIMT 496
            ....:.::|||||.:||||.|||..|:|.  ::.:..:.|..|. ||:.:..|....||:.|::.
Human   436 VMYKKNHEQLEGNERYEGYCVDLAYEIAKHVRIKYKLSIVGDGK-YGARDPETKIWNGMVGELVY 499

  Fly   497 GRADLAITDLTITSEREQALDFTIPFMNLGIAILYLKPQKATPELFTFMDPFSEEVWWFLGFSFL 561
            ||||:|:..||||..||:.:||:.|||:|||:|:..||||:.|.:|:|:||.:.|:|..:.|:::
Human   500 GRADIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYI 564

  Fly   562 GVSLSFFILGRLSPSEW---DNPYPCIEEPEELE------NQFTLGNSIWFTTGALLQQGSEIGP 617
            |||:..|::.|.||.||   ||.    |||.:.:      |:|.:.||:||:.||.:|||.:|.|
Human   565 GVSVVLFLVSRFSPYEWHLEDNN----EEPRDPQSPPDPPNEFGIFNSLWFSLGAFMQQGCDISP 625

  Fly   618 KALSTRTVASFWWFFTLIVVSSYTANLAAFLTIEKPQSLINSVDDLADNKDGVVYGAKKTGSTRN 682
            ::||.|.|...|||||||::||||||||||||:|:..|.|.|.:|||...: :.||...:|||:.
Human   626 RSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTE-IAYGTLDSGSTKE 689

  Fly   683 FFMTSAEERYKKMNKFM-SENPQYLTEDNMEGVNRV-KTNTHYAFLMESTSIEYNTKRE-CNLKK 744
            ||..|....|:||..:| |..|...|:...:||.|| |:...:|||:|||..||..:|: |:..|
Human   690 FFRRSKIAVYEKMWSYMKSAEPSVFTKTTADGVARVRKSKGKFAFLLESTMNEYIEQRKPCDTMK 754

  Fly   745 IGDALDEKGYGIAMRKDWPHRGKFNNALLELQEQGVLEKMKNKWW---NEVGTGICATKEDAPDA 806
            :|..||.||||:|..|....|...|.|:|:|.|||:|:|:|||||   .|.|:|    ..|:.|.
Human   755 VGGNLDSKGYGVATPKGSALRNAVNLAVLKLNEQGLLDKLKNKWWYDKGECGSG----GGDSKDK 815

  Fly   807 T-PLDMNNLEGVFFVLLVGSCCALLYGIISW 836
            | .|.::|:.|||::|:.|...|::..:|.:
Human   816 TSALSLSNVAGVFYILVGGLGLAMMVALIEF 846

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
GluRIIENP_001036733.1 PBP1_iGluR_Kainate 42..396 CDD:107377 95/380 (25%)
ANF_receptor 51..382 CDD:279440 85/357 (24%)
PBP2_iGluR_Kainate 419..790 CDD:270432 169/387 (44%)
Lig_chan 551..824 CDD:278489 127/288 (44%)
GRIA3NP_000819.4 PBP1_iGluR_AMPA_GluR3 35..409 CDD:380610 99/393 (25%)
PBP2_iGluR_AMPA 422..805 CDD:270433 169/388 (44%)
Glutamate binding. /evidence=ECO:0000250 508..510 0/1 (0%)