DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIE and Grin2d

DIOPT Version :9

Sequence 1:	NP_001036733.1	Gene:	GluRIIE / 318623	FlyBaseID:	FBgn0051201	Length:	897	Species:	Drosophila melanogaster
Sequence 2:	XP_038951440.1	Gene:	Grin2d / 24412	RGDID:	2740	Length:	1334	Species:	Rattus norvegicus

Alignment Length:	908	Identity:	202/908 - (22%)
Similarity:	358/908 - (39%)	Gaps:	178/908 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 AIDVANQEVGTSLTSLKEEVNYGDAYQSYGKLCRMLETGI---AGVFGPSSRHTAV----HLMSI 116
            |:..|.:..|..:..:...:|..|......:||.:| :|:   ..||...||..||    ..:|.
  Rat    69 AVAAAVRSPGLDVRPVALVLNGSDPRSLVLQLCDLL-SGLRVHGVVFEDDSRAPAVAPILDFLSA 132

  Fly   117 CDAMDIPHIYS----YMSENAEG---FNLHPHPADLAKALYSLITEFNWTRFIFLYESA------ 168
            ..::.|..::.    .::...:|   ..|........:.::.::.|::||.|:.:...|
  Rat   133 QTSLPIVAVHGGAALVLTPKEKGSTFLQLGSSTEQQLQVIFEVLEEYDWTSFVAVTTRAPGHRAF 197

  Fly   169 -EYLNILNE-----------LTTMLGKSGTVITVLRYDMQLNGNYKQVLRRVRKSVDNRIVVVGS 221
             .|:.:|.:           ||...|....|:..             .||.|  |...|::....
  Rat   198 LSYIEVLTDGSLVGWEHRGALTLDPGAGEAVLGA-------------QLRSV--SAQIRLLFCAR 247

  Fly   222 SETMPEFLNQAQQVGIINEDYKYIIGNLDFHSFDLEEYKYSEANITGLRLFSPEKMAV--KELLM 284
            .|..|.| ..|::.|:....|.:.                    :.|.:|.......|  :.||:
  Rat   248 EEAEPVF-RAAEEAGLTGPGYVWF--------------------MVGPQLAGGGGSGVPGEPLLL 291

  Fly   285 KLGYPTDQDEFRNGSCPITVEMALTYDA-VQLFAQ----TLKNLPFKP-MPQNCSQRTESVRDDG 343
            ..|.|.....|...|.....::|....| |.:.|:    .|::..|.| :..:|  ||::....|
  Rat   292 PGGSPLPAGLFAVRSAGWRDDLARRVAAGVAVVARGAQALLRDYGFLPELGHDC--RTQNRTHRG 354

  Fly   344 SSFKNYMRTLRLTDRLLTGPIYFEGNVRKGYHLDVIELQPSGIV----------KVGTWDEDRQY 398
            .|...|...:...:|            ...::.|...:.||.:|          .||:|::....
  Rat   355 ESLHRYFMNITWDNR------------DYSFNEDGFLVNPSLVVISLTRDRTWEVVGSWEQQTLR 407

  Fly   399 RPQRLAPTTAQF-DSVDN-------SLANKTFIILL------------SVPNKPYAQLVETYKQL 443
            ....|.....:| ..||:       :|..:.|:|:.            |||.:  :||..|:...
  Rat   408 LKYPLWSRYGRFLQPVDDTQHLTVATLEERPFVIVEPADPISGTCIRDSVPCR--SQLNRTHSPP 470

  Fly   444 EGNSQYE-----GYGVDLIKELADKLGFNFTFVNGGNDYGSYNKSTNES-TGMLREIMTGRADLA 502
            ....:.|     |:.:|::|.||..:||::......|  |.:.|..:.. .||:.|:...|||:|
  Rat   471 PDAPRPEKRCCKGFCIDILKRLAHTIGFSYDLYLVTN--GKHGKKIDGVWNGMIGEVFYQRADMA 533

  Fly   503 ITDLTITSEREQALDFTIPFMNLGIAILYLKPQ-KATPELFTFM---------DPFSEEVWWFLG 557
            |..|||..||.:.:||::||:..||:::..:.. ..:|..|...         :|:|..||..:.
  Rat   534 IGSLTINEERSEIVDFSVPFVETGISVMVARSNGTVSPSAFLAFAWLTPPMSPEPYSPAVWVMMF 598

  Fly   558 FSFLG-VSLSFFILGRLSPSEWDNPYPCIEEPEELENQFTLGNSIWFTTGALLQQGSEI-GPKAL 620
            ...|. |:::.||...|||..::......:.|.  .:.||:|.|||.....:......: .|:..
  Rat   599 VMCLTVVAVTVFIFEYLSPVGYNRSLATGKRPG--GSTFTIGKSIWLLWALVFNNSVPVENPRGT 661

  Fly   621 STRTVASFWWFFTLIVVSSYTANLAAFLTIEKPQSLINSVDDLADNK--------DGVVYGAKKT 677
            :::.:...|.||.:|.::|||||||||:..|:   .:::|..|:|.|        ..:.:|....
  Rat   662 TSKIMVLVWAFFAVIFLASYTANLAAFMIQEE---YVDTVSGLSDRKFQRPQEQYPPLKFGTVPN 723

  Fly   678 GSTRNFFMTSAEERYKKMNKFMSENPQYLTEDNMEGVNRVKTNTHYAFLMESTSIEYNTKRE--C 740
            |||..    :....|..|:.:|....|...|   |.:.::|.....||:.::..:.|..:::  |
  Rat   724 GSTEK----NIRSNYPDMHSYMVRYNQPRVE---EALTQLKAGKLDAFIYDAAVLNYMARKDEGC 781

  Fly   741 NLKKIGD--ALDEKGYGIAMRKDWPHRGKFNNALLELQEQGVLEKMKNKWWNEVGTGICATKEDA 803
            .|..||.  .....|||||:.|....:...:.|||:......:|.::..|.    :|||...:..
  Rat   782 KLVTIGSGKVFATTGYGIALHKGSRWKRPIDLALLQFLGDDEIEMLERLWL----SGICHNDKIE 842

  Fly   804 PDATPLDMNNLEGVFFVLLVGSCCALLYGIISWVLFVMKKAHHYRVPLRDALKEEFQFVIDFN 866
            ..::.||::|:.|||::|||....:||  :.:|...|..:..|...|     .....|::.|:
  Rat   843 VMSSKLDIDNMAGVFYMLLVAMGLSLL--VFAWEHLVYWRLRHCLGP-----THRMDFLLAFS 898

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIE	NP_001036733.1	PBP1_iGluR_Kainate	42..396	CDD:107377	71/386 (18%)
		ANF_receptor	51..382	CDD:279440	65/362 (18%)
		PBP2_iGluR_Kainate	419..790	CDD:270432	106/412 (26%)
		Lig_chan	551..824	CDD:278489	75/286 (26%)
Grin2d	XP_038951440.1	PBP1_iGluR_NMDA_NR2	46..410	CDD:380601	71/391 (18%)
		PBP2_iGluR_NMDA_Nr2	427..838	CDD:270436	110/430 (26%)
		PHA03307	<1125..>1312	CDD:223039
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349875
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.740