DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIE and Grin2c

DIOPT Version :9

Sequence 1:	NP_001036733.1	Gene:	GluRIIE / 318623	FlyBaseID:	FBgn0051201	Length:	897	Species:	Drosophila melanogaster
Sequence 2:	NP_036707.3	Gene:	Grin2c / 24411	RGDID:	2739	Length:	1250	Species:	Rattus norvegicus

Alignment Length:	953	Identity:	216/953 - (22%)
Similarity:	370/953 - (38%)	Gaps:	253/953 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 LTDQNTEQMNIVFDHAIDVANQEVGTSLTSLKEEVNYGDAYQSYGKLCRMLETGIAGVFGPSSRH 108
            ||.||      ..|..:::....||.:.|:...                 :.|.|.|:.|.:..|
  Rat    63 LTSQN------FLDLPLEIQPLTVGVNNTNPSS-----------------ILTQICGLLGAARVH 104

  Fly   109 TAVHLMSICDAMDIPHIYSYMSENAE--------------------------GFNLHPHPADLAK 147
            ..|...:: |...:..:..::|....                          |.:|...    .:
  Rat   105 GIVFEDNV-DTEAVAQLLDFVSSQTHVPILSISGGSAVVLTPKEPGSAFLQLGVSLEQQ----LQ 164

  Fly   148 ALYSLITEFNWTRF-----------IFL-----YESAEYLN--ILNELTTMLGKSGTVITVLRYD 194
            .|:.::.|::|:.|           :||     ...|.||:  :|:.||..||..|.
  Rat   165 VLFKVLEEYDWSAFAVITSLHPGHALFLEGVRAVADASYLSWRLLDVLTLELGPGGP-------- 221

  Fly   195 MQLNGNYKQVLRRVRKSVDNRIVVVGSSETMPEFL-NQAQQVGIINEDYKYIIGNLDFHSFDLEE 258
                   :...:|:.:.||..::|...|....|.| .:|.|.|::...:.:::.||...|.|...
  Rat   222 -------RARTQRLLRQVDAPVLVAYCSREEAEVLFAEAAQAGLVGPGHVWLVPNLALGSTDAPP 279

  Fly   259 YKYSEANIT----GLRLFSPEKMAVKELLMKLGYPTDQDEFRNGSCPITVEMALTYDAVQLFAQT 319
            ..:....|:    ..||...:|:.....::.||..:.:.::  |:.|...
  Rat   280 AAFPVGLISVVTESWRLSLRQKVRDGVAILALGAHSYRRQY--GTLPAPA--------------- 327

  Fly   320 LKNLPFKPMPQNCSQRTESVRDDGSSFKNYMRTLRLTDRLLTGPIYFEG---NVRKGYHLDVIEL 381
                      .:|......|.....:|  |...|.:|         :||   :...|.:|    :
  Rat   328 ----------GDCRSHPGPVSPAREAF--YRHLLNVT---------WEGRDFSFSPGGYL----V 367

  Fly   382 QPSGIV----------KVGTWDEDRQYRPQRLAP--TTAQFDSVDN------SLANKTFIILLS- 427
            :|:.:|          .||.||....|....:.|  :|:....||:      :|..:.|:|:.|
  Rat   368 RPTMVVIALNRHRLWEMVGRWDHGVLYMKYPVWPRYSTSLQPVVDSRHLTVATLEERPFVIVESP 432

  Fly   428 -------VPN-----------------KPYAQLVETYKQLEGNSQYEGYGVDLIKELADKLGFNF 468
                   |||                 .||.:|.           .:|:.:|::|:||..:.|::
  Rat   433 DPGTGGCVPNTVPCRRQSNHTFSSGDLTPYTKLC-----------CKGFCIDILKKLAKVVKFSY 486

  Fly   469 TFV------NGGNDYGSYNKSTNESTGMLREIMTGRADLAITDLTITSEREQALDFTIPFMNLGI 527
            ...      :|....|.:|       ||:.|:...|||:||..|||..||.:.:||::||:..||
  Rat   487 DLYLVTNGKHGKRVRGVWN-------GMIGEVYYKRADMAIGSLTINEERSEIIDFSVPFVETGI 544

  Fly   528 AILYLKPQKATPELFTFMDPFSEEVWWFLGFSFLG-VSLSFFILGRLSPSEWDNPYPCIEEPEEL 591
            ::: :.....|.....|::|:|..||..:....|. |:::.|:....||..::......::|.
  Rat   545 SVM-VSRSNGTVSPSAFLEPYSPAVWVMMFVMCLTVVAITVFMFEYFSPVSYNQNLTKGKKPG-- 606

  Fly   592 ENQFTLGNSIWFTTGALLQQGSEI-GPKALSTRTVASFWWFFTLIVVSSYTANLAAFLTIEKPQS 655
            ...||:|.|:|.....:......| .|:..:::.:...|.||.:|.::|||||||||:..|:
  Rat   607 GPSFTIGKSVWLLWALVFNNSVPIENPRGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEQ--- 668

  Fly   656 LINSVDDLADNK--------DGVVYGAKKTGST-RNFFMTSAEERYKKMNKFMSENPQYLTEDNM 711
            .|::|..|:|.|        ....:|....||| ||.     ...|:.|:..|.:..|...||.:
  Rat   669 YIDTVSGLSDKKFQRPQDQYPPFRFGTVPNGSTERNI-----RSNYRDMHTHMVKFNQRSVEDAL 728

  Fly   712 EGVNRVKTNTHYAFLMESTSIEYNTKRE--CNLKKIGD--ALDEKGYGIAMRKDWPHRGKFNNAL 772
            ..:...|.:   ||:.::..:.|...::  |.|..||.  .....||||||:||...:...:.||
  Rat   729 TSLKMGKLD---AFIYDAAVLNYMAGKDEGCKLVTIGSGKVFATTGYGIAMQKDSHWKRAIDLAL 790

  Fly   773 LELQEQGVLEKMKNKWWNEVGTGICATKEDAPDATPLDMNNLEGVFFVLLVGSCCALLYGIISWV 837
            |:|...|..:|::..|.    :|||..:::...::.||::|:.|||::|||....|||  :.:|.
  Rat   791 LQLLGDGETQKLETVWL----SGICQNEKNEVMSSKLDIDNMAGVFYMLLVAMGLALL--VFAWE 849

  Fly   838 LFVMKKAHHYRVPLRDALKEEFQFVIDFNNYVRVLKNSASIYS 880
            ..|..|..| .||....|        ||     :|..|..|||
  Rat   850 HLVYWKLRH-SVPNSSQL--------DF-----LLAFSRGIYS 878

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIE	NP_001036733.1	PBP1_iGluR_Kainate	42..396	CDD:107377	71/413 (17%)
		ANF_receptor	51..382	CDD:279440	61/382 (16%)
		PBP2_iGluR_Kainate	419..790	CDD:270432	110/416 (26%)
		Lig_chan	551..824	CDD:278489	80/287 (28%)
Grin2c	NP_036707.3	PBP1_iGluR_NMDA_NR2	41..397	CDD:380601	72/418 (17%)
		PBP2_iGluR_NMDA_Nr2	413..813	CDD:270436	114/435 (26%)
		NMDAR2_C	850..>925	CDD:402274	13/43 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349887
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.740