DRSC/TRiP Functional Genomics Resources

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Protein Alignment GluRIIE and Grin2b

DIOPT Version :9

Sequence 1:NP_001036733.1 Gene:GluRIIE / 318623 FlyBaseID:FBgn0051201 Length:897 Species:Drosophila melanogaster
Sequence 2:NP_036706.1 Gene:Grin2b / 24410 RGDID:2738 Length:1482 Species:Rattus norvegicus


Alignment Length:898 Identity:203/898 - (22%)
Similarity:369/898 - (41%) Gaps:189/898 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    31 DNYQSLESVP-IGLLTDQNTEQMNIVFDHAIDVANQEVGTSLTSLKEE------VNYGDAYQSYG 88
            |::..|..|| :.|:....|:..:|:             |.:..|..:      |...|..|.  
  Rat    57 DDFHHLSVVPRVELVAMNETDPKSII-------------TRICDLMSDRKIQGVVFADDTDQE-- 106

  Fly    89 KLCRMLE-------TGIAGVFGPSSRHTAVHLMSICDAMDIPHIYSYMSENAEGFNLHPHPADLA 146
            .:.::|:       |.|.|:.|.||       |.:.|          ..|::..|...|.....|
  Rat   107 AIAQILDFISAQTLTPILGIHGGSS-------MIMAD----------KDESSMFFQFGPSIEQQA 154

  Fly   147 KALYSLITEFNWTRFIFLYESA---EYLNILNELTTMLGKS---GTVITVLRYDMQLNGNYKQVL 205
            ..:.:::.|::|  :||...:.   .|.:.:|::.:.:..|   ..:..||..||.|:....::.
  Rat   155 SVMLNIMEEYDW--YIFSIVTTYFPGYQDFVNKIRSTIENSFVGWELEEVLLLDMSLDDGDSKIQ 217

  Fly   206 RRVRKSVDNRIVVVGSSETMPEFLNQAQQVGIINEDYKYIIGNLDFHSFDLEEYKYSEANITGLR 270
            .:::|.....|::..:.|........|..||:....|.:|:.:|.....|....::.    |||.
  Rat   218 NQLKKLQSPIILLYCTKEEATYIFEVANSVGLTGYGYTWIVPSLVAGDTDTVPSEFP----TGLI 278

  Fly   271 LFSPEKMAVKELLMKLGYPTDQDEFRNGSCPITVEMALTYDAVQLFAQTLKNLPFKPMPQNCSQR 335
            ..|.::       ...|.|.   ..|:|...||...          :..|....|.|.|::....
  Rat   279 SVSYDE-------WDYGLPA---RVRDGIAIITTAA----------SDMLSEHSFIPEPKSSCYN 323

  Fly   336 TESVRDDGSSFKNYMRTLRLTDRLLTGPIYFEGNVRKGYHLDVIELQPSGIV----------KVG 390
            |...|...|:..|         |.|.. :.|||. ...:..|..::.|..::          :||
  Rat   324 THEKRIYQSNMLN---------RYLIN-VTFEGR-NLSFSEDGYQMHPKLVIILLNKERKWERVG 377

  Fly   391 TWDED----RQYRPQRLAPTTAQFDSVDNSLANKTFIILLSVPNKPYAQLVETYKQLEGNSQ--- 448
            .|.:.    :.|...|:.|.|.:.:  |:.|:      ::::...|:. :||:...|.|...   
  Rat   378 KWKDKSLQMKYYVWPRMCPETEEQE--DDHLS------IVTLEEAPFV-IVESVDPLSGTCMRNT 433

  Fly   449 -----------------------YEGYGVDLIKELADKLGFNFTFVNGGNDYGSYNKSTNES-TG 489
                                   .:|:.:|::|:::..:.|.:......|  |.:.|..|.: .|
  Rat   434 VPCQKRIISENKTDEEPGYIKKCCKGFCIDILKKISKSVKFTYDLYLVTN--GKHGKKINGTWNG 496

  Fly   490 MLREIMTGRADLAITDLTITSEREQALDFTIPFMNLGIAILYLKPQKATPELFTFMDPFSEEVWW 554
            |:.|::..||.:|:..|||..||.:.:||::||:..||::: :.....|.....|::|||.:||.
  Rat   497 MIGEVVMKRAYMAVGSLTINEERSEVVDFSVPFIETGISVM-VSRSNGTVSPSAFLEPFSADVWV 560

  Fly   555 FLGFSFLGVS-LSFFILGRLSPSEWDNPYPCIEEPEELEN-QFTLGNSIWFTTGALLQQGSEI-G 616
            .:....|.|| ::.|:....||..::.   |:.:..|... .||:|.:||...|.:......: .
  Rat   561 MMFVMLLIVSAVAVFVFEYFSPVGYNR---CLADGREPGGPSFTIGKAIWLLWGLVFNNSVPVQN 622

  Fly   617 PKALSTRTVASFWWFFTLIVVSSYTANLAAFLTIEKPQSLINSVDDLADNK--------DGVVYG 673
            ||..:::.:.|.|.||.:|.::|||||||||:..|:   .::.|..|:|.|        ....:|
  Rat   623 PKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEE---YVDQVSGLSDKKFQRPNDFSPPFRFG 684

  Fly   674 AKKTGSTRNFFMTSAEERYKKMNKFMSENPQYLTEDNMEGVN----RVKTNTHYAFLMESTSIEY 734
            ....|||......:..|.:..|.||           |..||:    .:||....||:.::..:.|
  Rat   685 TVPNGSTERNIRNNYAEMHAYMGKF-----------NQRGVDDALLSLKTGKLDAFIYDAAVLNY 738

  Fly   735 NTKRE--CNLKKIGD--ALDEKGYGIAMRKDWPHRGKFNNALLELQEQGVLEKMKNKWWNEVGTG 795
            ...|:  |.|..||.  .....|||||::||...:.:.:.|:|:|...|.:|:::..|.    ||
  Rat   739 MAGRDEGCKLVTIGSGKVFASTGYGIAIQKDSGWKRQVDLAILQLFGDGEMEELEALWL----TG 799

  Fly   796 ICATKEDAPDATPLDMNNLEGVFFVLLVGSCCALLYGIISWVLFVMKKAHHYR 848
            ||..:::...::.||::|:.|||::|  |:..||     |.:.|:.:...:::
  Rat   800 ICHNEKNEVMSSQLDIDNMAGVFYML--GAAMAL-----SLITFICEHLFYWQ 845

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
GluRIIENP_001036733.1 PBP1_iGluR_Kainate 42..396 CDD:107377 71/386 (18%)
ANF_receptor 51..382 CDD:279440 65/349 (19%)
PBP2_iGluR_Kainate 419..790 CDD:270432 106/416 (25%)
Lig_chan 551..824 CDD:278489 82/291 (28%)
Grin2bNP_036706.1 PBP1_iGluR_NMDA_NR2 33..393 CDD:107373 76/404 (19%)
PBP2_iGluR_NMDA_Nr2 403..803 CDD:270436 112/430 (26%)
HisJ <459..>542 CDD:223904 25/85 (29%)
Lig_chan 557..829 CDD:278489 83/294 (28%)
Pore-forming. /evidence=ECO:0000269|PubMed:24876489, ECO:0000305|PubMed:24876489 604..623 3/18 (17%)