DRSC/TRiP Functional Genomics Resources

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Protein Alignment GluRIIE and Grin2a

DIOPT Version :9

Sequence 1:NP_001036733.1 Gene:GluRIIE / 318623 FlyBaseID:FBgn0051201 Length:897 Species:Drosophila melanogaster
Sequence 2:NP_036705.3 Gene:Grin2a / 24409 RGDID:2737 Length:1464 Species:Rattus norvegicus


Alignment Length:982 Identity:224/982 - (22%)
Similarity:390/982 - (39%) Gaps:246/982 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    54 IVFDHAIDVANQEVGT-----SLTSLKEEVNY-------GDAYQSYGKLCRMLE-TGIAG-VFGP 104
            ::..|:.||..:|:..     ..|.|..:||.       .|.......:|.::. ..|.| |||.
  Rat    38 VLLGHSHDVTERELRNLWGPEQATGLPLDVNVVALLMNRTDPKSLITHVCDLMSGARIHGLVFGD 102

  Fly   105 SSRHTAVHLM--SICDAMDIP----H-----IYSYMSENAEGFNLHPHPADLAKALYSLITEFNW 158
            .:...||..|  .|.....||    |     |.:.....:..|.........|..:..::.:::|
  Rat   103 DTDQEAVAQMLDFISSQTFIPILGIHGGASMIMADKDPTSTFFQFGASIQQQATVMLKIMQDYDW 167

  Fly   159 TRF-----IFLYESAEYLNILNELTTMLGKSGTVITVLRYDMQ----LNGNYKQV-----LRRVR 209
            ..|     ||    ..|.:.::.:.|.:..|     .:.:|||    |:.:::..     |:::.
  Rat   168 HVFSLVTTIF----PGYRDFISFIKTTVDNS-----FVGWDMQNVITLDTSFEDAKTQVQLKKIH 223

  Fly   210 KSVDNRIVVVGSSETMPEFLNQAQQVGIINEDYKYII-----GNLD---------FHSFDLEEYK 260
            .||   |::..|.:.....|::|:.:|:...|:.:|:     ||.:         ..|...:::.
  Rat   224 SSV---ILLYCSKDEAVLILSEARSLGLTGYDFFWIVPSLVSGNTELIPKEFPSGLISVSYDDWD 285

  Fly   261 YS-EANI-TGLRLFSPEKMAVKELLMKLGYPTDQDEFRNGSCPITVEMALTYDAVQLFAQTLKNL 323
            || ||.: .||.:.:   .|...:|.|..|..:    ...||               :.|..|  
  Rat   286 YSLEARVRDGLGILT---TAASSMLEKFSYIPE----AKASC---------------YGQAEK-- 326

  Fly   324 PFKPMPQNCSQRTESVRDDGSSFKNYMRTLRLTDRLLTGPIYFEGNVRKGYHLDVIELQPSGIV- 387
            |..|: ....|...:|..||       :.|..|:              :||     ::.|..:| 
  Rat   327 PETPL-HTLHQFMVNVTWDG-------KDLSFTE--------------EGY-----QVHPRLVVI 364

  Fly   388 ---------KVGTWDEDRQYRPQRLAPTTAQFDSV---DNSLANKT-----FIIL---------- 425
                     |||.|:.........:.|....|...   ||.|:..|     |:|:          
  Rat   365 VLNKDREWEKVGKWENQTLSLRHAVWPR
YKSFSDCEPDDNHLSIVTLEEAPFVIVEDIDPLTETC 429

  Fly   426 --LSVPNKPYAQLVETYKQLEGNSQYE---------GYGVDLIKELADKLGFNFTFVNGGNDYGS 479
              .:||.:.:.::        .||..|         |:.:|::|:|:..:.|.:......|  |.
  Rat   430 VRNTVPCRKFVKI--------NNSTNEGMNVKKCCKGFCIDILKKLSRTVKFTYDLYLVTN--GK 484

  Fly   480 YNKSTNES-TGMLREIMTGRADLAITDLTITSEREQALDFTIPFMNLGIAILYLKPQKATPELFT 543
            :.|..|.. .||:.|::..||.:|:..|||..||.:.:||::||:..||::: :.....|.....
  Rat   485 HGKKVNNVWNGMIGEVVYQRAVMAVGSLTINEERSEVVDFSVPFVETGISVM-VSRSNGTVSPSA 548

  Fly   544 FMDPFSEEVWWFLGFSFLGVS-LSFFILGRLSPSEWDNPYPCIEEPEELENQFTLGNSIWFTTGA 607
            |::|||..||..:....|.|| ::.|:....||..::......:.|.  ...||:|.:||...|.
  Rat   549 FLEPFSASVWVMMFVMLLIVSAIAVFVFEYFSPVGYNRNLAKGKAPH--GPSFTIGKAIWLLWGL 611

  Fly   608 LLQQGSEI-GPKALSTRTVASFWWFFTLIVVSSYTANLAAFLTIEKPQSLINSVDDLADNK---- 667
            :......: .||..:::.:.|.|.||.:|.::|||||||||:..|:   .::.|..|:|.|    
  Rat   612 VFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEE---FVDQVTGLSDKKFQRP 673

  Fly   668 ----DGVVYGAKKTGST-RNFFMTSAEERYKKMNKFMSENPQYLTEDNMEGVN----RVKTNTHY 723
                ....:|....||| ||.     ...|..|:       ||:|..|..||.    .:||....
  Rat   674 HDYSPPFRFGTVPNGSTERNI-----RNNYPYMH-------QYMTRFNQRGVEDALVSLKTGKLD 726

  Fly   724 AFLMESTSIEYNTKRE--CNLKKIGDA--LDEKGYGIAMRKDWPHRGKFNNALLELQEQGVLEKM 784
            ||:.::..:.|...|:  |.|..||..  ....|||||::|..|.:.:.:.|||:....|.:|::
  Rat   727 AFIYDAAVLNYKAGRDEGCKLVTIGSGYIFATTGYGIALQKGSPWKRQIDLALLQFVGDGEMEEL 791

  Fly   785 KNKWWNEVGTGICATKEDAPDATPLDMNNLEGVFFVLLVGSCCALL----------------YGI 833
            :..|.    ||||..:::...::.||::|:.|||::|......:|:                .|:
  Rat   792 ETLWL----TGICHNEKNEVMSSQLDIDNMAGVFYMLAAAMALSLITFIWEHLFYWKLRFCFTGV 852

  Fly   834 IS---WVLFVMKKA-----HHYRVPLRDALKEEFQFVIDFN------NYVRVLKNSASIYSRSRQ 884
            .|   .:||.:.:.     |...:       ||.:...|||      |.:::|:::.:|.:.|..
  Rat   853 CSDRPGLLFSISRGIYSCIHGVHI-------EEKKKSPDFNLTGSQSNMLKLLRSAKNISNMSNM 910

  Fly   885 SSMSVAS 891
            :|..:.|
  Rat   911 NSSRMDS 917

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
GluRIIENP_001036733.1 PBP1_iGluR_Kainate 42..396 CDD:107377 79/406 (19%)
ANF_receptor 51..382 CDD:279440 73/382 (19%)
PBP2_iGluR_Kainate 419..790 CDD:270432 112/416 (27%)
Lig_chan 551..824 CDD:278489 84/291 (29%)
Grin2aNP_036705.3 PBP1_iGluR_NMDA_NR2 32..392 CDD:107373 79/416 (19%)
PBP2_iGluR_NMDA_Nr2 403..802 CDD:270436 119/430 (28%)
HisJ <458..>541 CDD:223904 26/85 (31%)
Glutamate binding. /evidence=ECO:0000269|PubMed:16281028, ECO:0007744|PDB:2A5S, ECO:0007744|PDB:2A5T, ECO:0007744|PDB:4NF4, ECO:0007744|PDB:4NF8, ECO:0007744|PDB:5I56, ECO:0007744|PDB:5I57, ECO:0007744|PDB:5I58, ECO:0007744|PDB:5I59, ECO:0007744|PDB:5JTY 511..513 0/1 (0%)
Lig_chan 556..828 CDD:278489 84/292 (29%)
Pore-forming. /evidence=ECO:0000250|UniProtKB:B7ZSK1 599..620 6/20 (30%)