Protein Alignment GluRIIE and Grin2a

DIOPT Version :10

• Sequence 1: NP_001036733.1
• Gene: GluRIIE / 318623
• FlyBaseID: FBgn0051201
• Length: 897
• Species: Drosophila melanogaster
• Sequence 2: NP_036705.3
• Gene: Grin2a / 24409
• RGDID: 2737
• Length: 1464
• Species: Rattus norvegicus
• Alignment Length: 982
• Identity: 224/982 - (22%)
• Similarity: 390/982 - (39%)
• Gaps: 246/982 - (25%)

  Fly    54 IVFDHAIDVANQEVGT-----SLTSLKEEVNY-------GDAYQSYGKLCRMLE-TGIAG-VFGP 104
            ::..|:.||..:|:..     ..|.|..:||.       .|.......:|.::. ..|.| |||.
  Rat    38 VLLGHSHDVTERELRNLWGPEQATGLPLDVNVVALLMNRTDPKSLITHVCDLMSGARIHGLVFGD 102

  Fly   105 SSRHTAVHLM--SICDAMDIP----H-----IYSYMSENAEGFNLHPHPADLAKALYSLITEFNW 158
            .:...||..|  .|.....||    |     |.:.....:..|.........|..:..::.:::|
  Rat   103 DTDQEAVAQMLDFISSQTFIPILGIHGGASMIMADKDPTSTFFQFGASIQQQATVMLKIMQDYDW 167

  Fly   159 TRF-----IFLYESAEYLNILNELTTMLGKSGTVITVLRYDMQ----LNGNYKQV-----LRRVR 209
            ..|     ||    ..|.:.::.:.|.:..|     .:.:|||    |:.:::..     |:::.
  Rat   168 HVFSLVTTIF----PGYRDFISFIKTTVDNS-----FVGWDMQNVITLDTSFEDAKTQVQLKKIH 223

  Fly   210 KSVDNRIVVVGSSETMPEFLNQAQQVGIINEDYKYII-----GNLD---------FHSFDLEEYK 260
            .||   |::..|.:.....|::|:.:|:...|:.:|:     ||.:         ..|...:::.
  Rat   224 SSV---ILLYCSKDEAVLILSEARSLGLTGYDFFWIVPSLVSGNTELIPKEFPSGLISVSYDDWD 285

  Fly   261 YS-EANI-TGLRLFSPEKMAVKELLMKLGYPTDQDEFRNGSCPITVEMALTYDAVQLFAQTLKNL 323
            || ||.: .||.:.:   .|...:|.|..|..:    ...||               :.|..|
  Rat   286 YSLEARVRDGLGILT---TAASSMLEKFSYIPE----AKASC---------------YGQAEK-- 326

  Fly   324 PFKPMPQNCSQRTESVRDDGSSFKNYMRTLRLTDRLLTGPIYFEGNVRKGYHLDVIELQPSGIV- 387
            |..|: ....|...:|..||       :.|..|:              :||     ::.|..:|
  Rat   327 PETPL-HTLHQFMVNVTWDG-------KDLSFTE--------------EGY-----QVHPRLVVI 364

  Fly   388 ---------KVGTWDEDRQYRPQRLAPTTAQFDSV---DNSLANKT-----FIIL---------- 425
                     |||.|:.........:.|....|...   ||.|:..|     |:|:
  Rat   365 VLNKDREWEKVGKWENQTLSLRHAVWPRYKSFSDCEPDDNHLSIVTLEEAPFVIVEDIDPLTETC 429

  Fly   426 --LSVPNKPYAQLVETYKQLEGNSQYE---------GYGVDLIKELADKLGFNFTFVNGGNDYGS 479
              .:||.:.:.::        .||..|         |:.:|::|:|:..:.|.:......|  |.
  Rat   430 VRNTVPCRKFVKI--------NNSTNEGMNVKKCCKGFCIDILKKLSRTVKFTYDLYLVTN--GK 484

  Fly   480 YNKSTNES-TGMLREIMTGRADLAITDLTITSEREQALDFTIPFMNLGIAILYLKPQKATPELFT 543
            :.|..|.. .||:.|::..||.:|:..|||..||.:.:||::||:..||::: :.....|.....
  Rat   485 HGKKVNNVWNGMIGEVVYQRAVMAVGSLTINEERSEVVDFSVPFVETGISVM-VSRSNGTVSPSA 548

  Fly   544 FMDPFSEEVWWFLGFSFLGVS-LSFFILGRLSPSEWDNPYPCIEEPEELENQFTLGNSIWFTTGA 607
            |::|||..||..:....|.|| ::.|:....||..::......:.|.  ...||:|.:||...|.
  Rat   549 FLEPFSASVWVMMFVMLLIVSAIAVFVFEYFSPVGYNRNLAKGKAPH--GPSFTIGKAIWLLWGL 611

  Fly   608 LLQQGSEI-GPKALSTRTVASFWWFFTLIVVSSYTANLAAFLTIEKPQSLINSVDDLADNK---- 667
            :......: .||..:::.:.|.|.||.:|.::|||||||||:..|:   .::.|..|:|.|
  Rat   612 VFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEE---FVDQVTGLSDKKFQRP 673

  Fly   668 ----DGVVYGAKKTGST-RNFFMTSAEERYKKMNKFMSENPQYLTEDNMEGVN----RVKTNTHY 723
                ....:|....||| ||.     ...|..|:       ||:|..|..||.    .:||....
  Rat   674 HDYSPPFRFGTVPNGSTERNI-----RNNYPYMH-------QYMTRFNQRGVEDALVSLKTGKLD 726

  Fly   724 AFLMESTSIEYNTKRE--CNLKKIGDA--LDEKGYGIAMRKDWPHRGKFNNALLELQEQGVLEKM 784
            ||:.::..:.|...|:  |.|..||..  ....|||||::|..|.:.:.:.|||:....|.:|::
  Rat   727 AFIYDAAVLNYKAGRDEGCKLVTIGSGYIFATTGYGIALQKGSPWKRQIDLALLQFVGDGEMEEL 791

  Fly   785 KNKWWNEVGTGICATKEDAPDATPLDMNNLEGVFFVLLVGSCCALL----------------YGI 833
            :..|.    ||||..:::...::.||::|:.|||::|......:|:                .|:
  Rat   792 ETLWL----TGICHNEKNEVMSSQLDIDNMAGVFYMLAAAMALSLITFIWEHLFYWKLRFCFTGV 852

  Fly   834 IS---WVLFVMKKA-----HHYRVPLRDALKEEFQFVIDFN------NYVRVLKNSASIYSRSRQ 884
            .|   .:||.:.:.     |...:       ||.:...|||      |.:::|:::.:|.:.|..
  Rat   853 CSDRPGLLFSISRGIYSCIHGVHI-------EEKKKSPDFNLTGSQSNMLKLLRSAKNISNMSNM 910

  Fly   885 SSMSVAS 891
            :|..:.|
  Rat   911 NSSRMDS 917

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIE	NP_001036733.1	PBP1_iGluR_Kainate	40..402	CDD:380605	79/412 (19%)
		PBP2_iGluR_Kainate	419..790	CDD:270432	112/416 (27%)
		Lig_chan	551..824	CDD:459656	84/291 (29%)
Grin2a	NP_036705.3	PBP1_iGluR_NMDA_NR2	32..387	CDD:380601	79/411 (19%)
		PBP2_iGluR_NMDA_Nr2	403..802	CDD:270436	119/430 (28%)
		Pore-forming. /evidence=ECO:0000250|UniProtKB:B7ZSK1	599..620		6/20 (30%)
		NMDAR2_C	839..1464	CDD:463148	16/86 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	989..1083
		PDZ-binding. /evidence=ECO:0000305	1462..1464