DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIE and Grik5

DIOPT Version :9

Sequence 1:	NP_001036733.1	Gene:	GluRIIE / 318623	FlyBaseID:	FBgn0051201	Length:	897	Species:	Drosophila melanogaster
Sequence 2:	XP_006228444.1	Gene:	Grik5 / 24407	RGDID:	2735	Length:	980	Species:	Rattus norvegicus

Alignment Length:	899	Identity:	297/899 - (33%)
Similarity:	447/899 - (49%)	Gaps:	101/899 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 QSLESVPIGLLTDQNT--------------EQMNIVFDHAIDV-ANQEVGTSLTSLKEEVNYGDA 83
            |.|.|:.:..:.|..|              ||:|.:    |:| |...|...:..|:.:    ..
  Rat    19 QVLSSLRMAAILDDQTVCGRGERLALALAREQINGI----IEVPAKARVEVDIFELQRD----SQ 75

  Fly    84 YQSYGKLCRMLETGIAGVFGPSSRHTAVHLMS-ICDAMDIPHIYSYMSENAE-------GFNLHP 140
            |::...:|::|..|:..|.||||...:...:| ||...:||||.....|...       ..:|:|
  Rat    76 YETTDTMCQILPKGVVSVLGPSSSPASASTVSHICGEKEIPHIKVGPEETPRLQYLRFASVSLYP 140

  Fly   141 HPADLAKALYSLITEFNWTRFIFLYESAEYLNILNELTTMLGKSGTVITVLRYDMQLNGNYKQVL 205
            ...|::.|:..::..||:.....:...||.|..|.||......|...::|...|...:..  .:|
  Rat   141 SNEDVSLAVSRILKSFNYPSASLICAKAECLLRLEELVRGFLISKETLSVRMLDDSRDPT--PLL 203

  Fly   206 RRVRKSVDNRIVVVGSSETMPEFLNQAQQVGIINEDYKYIIGNLDFHSFDLEEYKYSEANITGLR 270
            :.:|....:.|::..::......|.:|.::|:.:..||||:..:||....|:......:||.|..
  Rat   204 KEIRDDKVSTIIIDANASISHLVLRKASELGMTSAFYKYILTTMDFPILHLDGIVEDSSNILGFS 268

  Fly   271 LFS------PE-----KMAVKELLMKLGYPTDQDEFRNGSCPITVEMALTYDAVQLFAQTLKNL- 323
            :|:      ||     .|:.:|......||..           .:..||.:|||.:....::.|
  Rat   269 MFNTSHPFYPEFVRSLNMSWRENCEASTYPGP-----------ALSAALMFDAVHVVVSAVRELN 322

  Fly   324 -----PFKPMPQNCSQRTESVRDDGSSFKNYMRTLRLTDRLLTGPIYFEG-NVRKGYHLDVIELQ 382
                 ..||:.  |:  :.::...|:|..||:|.:....  |||.:.|.. ..|..|.|.::|..
  Rat   323 RSQEIGVKPLA--CT--SANIWPHGTSLMNYLRMVEYDG--LTGRVEFNSKGQRTNYTLRILEKS 381

  Fly   383 PSGIVKVGTWDEDRQYRPQRLAPTTAQFD-SVDNSLANKTFIILLSVPNKPYAQLVETYKQLEGN 446
            ..|..::|.|     |..:.||......| ::..:|||||.::...:.| ||......::.|.||
  Rat   382 RQGHREIGVW-----YSNRTLAMNATTLDINLSQTLANKTLVVTTILEN-PYVMRRPNFQALSGN 440

  Fly   447 SQYEGYGVDLIKELADKLGFNF--TFVNGGNDYGSYNKSTNES-TGMLREIMT-GRADLAITDLT 507
            .::||:.||:::|||:.|.|.:  ..|..|. ||:  ...|.| |||:.|::. .:||||:...|
  Rat   441 ERFEGFCVDMLRELAELLRFRYRLRLVEDGL-YGA--PEPNGSWTGMVGELINRQKADLAVAAFT 502

  Fly   508 ITSEREQALDFTIPFMNLGIAILYLKPQKATPELFTFMDPFSEEVWWFLGFSFLGVSLSFFILGR 572
            ||:|||:.:||:.|||.|||:|||.......|..|:|:||||..||.|:..::|.||...|:..|
  Rat   503 ITAEREKVIDFSKPFMTLGISILYRVHMGRKPGYFSFLDPFSPAVWLFMLLAYLAVSCVLFLAAR 567

  Fly   573 LSPSEWDNPYPCIE-EPEELENQFTLGNSIWFTTGALLQQGSEIGPKALSTRTVASFWWFFTLIV 636
            |||.||.||:||:. .|..||||:|||||:||..|..:||||||.|:|||||.|:..||.||||:
  Rat   568 LSPYEWYNPHPCLRARPHILENQYTLGNSLWFPVGGFMQQGSEIMPRALSTRCVSGVWWAFTLII 632

  Fly   637 VSSYTANLAAFLTIEKPQSLINSVDDLADNKDGVVYGAKKTGSTRNFFMTSAEERYKKM-NKFMS 700
            :||||||||||||:::.:..:.|.||||| :..:.||....|||..||..|..:.|::| |...|
  Rat   633 ISSYTANLAAFLTVQRMEVPVESADDLAD-QTNIEYGTIHAGSTMTFFQNSRYQTYQRMWNYMQS 696

  Fly   701 ENPQYLTEDNMEGVNRVKTNTHYAFLMESTSIEYNTKRECNLKKIGDALDEKGYGIAMRKDWPHR 765
            :.|....:...||:.|| .|:.||||:|||..||:.:..|||.:||..||.|||||.|....|.|
  Rat   697 KQPSVFVKSTEEGIARV-LNSRYAFLLESTMNEYHRRLNCNLTQIGGLLDTKGYGIGMPLGSPFR 760

  Fly   766 GKFNNALLELQEQGVLEKMKNKWWNEVGTGICATKEDAPDATPLDMNNLEGVFFVLLVGSCCALL 830
            .:...|:|:|||...||.:|.|||.   .|.|..:|| ..|..|.|.|:.|:|.||:.|...|:.
  Rat   761 DEITLAILQLQENNRLEILKRKWWE---GGRCPKEED-HRAKGLGMENIGGIFVVLICGLIIAVF 821

  Fly   831 YGIISWVLFVMKKAHHYRVPLRDALKEEFQFVIDFNNYVRVLKNSASIYSRSRQ 884
            ..::.::....:.|....|.:...:.:|.:..:           |....||||:
  Rat   822 VAVMEFIWSTRRSAESEEVSVCQEMLQELRHAV-----------SCRKTSRSRR 864

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIE	NP_001036733.1	PBP1_iGluR_Kainate	42..396	CDD:107377	90/394 (23%)
		ANF_receptor	51..382	CDD:279440	84/357 (24%)
		PBP2_iGluR_Kainate	419..790	CDD:270432	175/376 (47%)
		Lig_chan	551..824	CDD:278489	132/274 (48%)
Grik5	XP_006228444.1	PBP1_iGluR_Kainate_KA1_2	23..401	CDD:380616	94/409 (23%)
Grik5	XP_006228444.1	Periplasmic_Binding_Protein_Type_2	414..785	CDD:389745	175/376 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349896
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	1	1.010	-	-		D60688at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.660