DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIE and Grik4

DIOPT Version :9

Sequence 1:	NP_001036733.1	Gene:	GluRIIE / 318623	FlyBaseID:	FBgn0051201	Length:	897	Species:	Drosophila melanogaster
Sequence 2:	NP_036704.1	Gene:	Grik4 / 24406	RGDID:	2734	Length:	956	Species:	Rattus norvegicus

Alignment Length:	905	Identity:	287/905 - (31%)
Similarity:	450/905 - (49%)	Gaps:	100/905 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 SVPIGLL--------TDQNTEQMNIVFDHAIDVANQEVGTSLTSLKEEVN-----YGDA------ 83
            |.|:.||        ...::.::..:.|..::.:..| ..|:|..|..:|     .|.|
  Rat     5 SAPLVLLPAWLLMVACSPHSLRIAAILDDPMECSRGE-RLSITLAKNRINRAPERLGKAKVEVDI 68

  Fly    84 --------YQSYGKLCRMLETGIAGVFGPSSRHTAVHLMS-ICDAMDIPH-------IYSYMSEN 132
                    |::...:|::|..|:..|.||||...:..::| ||...::||       ...:..:.
  Rat    69 FELLRDSEYETAETMCQILPKGVVAVLGPSSSPASSSIISNICGEKEVPHFKVAPEEFVRFQLQR 133

  Fly   133 AEGFNLHPHPADLAKALYSLITEFNWTRFIFLYESAEYLNILNELTTMLGKSGTVITVLRYDMQL 197
            ....||||...|::.|:..::..||.|....:...||.|..|.:|......|...::|...|...
  Rat   134 FTTLNLHPSNTDISVAVAGILNFFNCTTACLICAKAECLLNLEKLLRQFLISKDTLSVRMLDDTR 198

  Fly   198 NGNYKQVLRRVRKSVDNRIVVVGSSETMPEFLNQAQQVGIINEDYKYIIGNLDFHSFDLEEYKYS 262
            :..  .:|:.:|......|::..::......|.:|.::|:::..|.||..||:|....::.....
  Rat   199 DPT--PLLKEIRDDKTATIIIHANASMSHTILLKAAELGMVSAYYTYIFTNLEFSLQRMDSLVDD 261

  Fly   263 EANITGLRLFSPEKMAVKELLMKLGYPTDQDEFRNGSC---PIT---VEMALTYDAVQLFAQTLK 321
            ..||.|..:|:......:|....|.....:      :|   |.|   :..||.:|||......::
  Rat   262 RVNILGFSIFNQSHAFFQEFSQSLNQSWQE------NCDHVPFTGPALSSALLFDAVYAVVTAVQ 320

  Fly   322 NL------PFKPMPQNCSQRTESVRDDGSSFKNYMRTLRLTDRLLTGPIYFEG-NVRKGYHLDVI 379
            .|      ..||:....:|    :...|:|..||:|.:.|..  |||.|.|.. ..|..|.|.::
  Rat   321 ELNRSQEIGVKPLSCGSAQ----IWQHGTSLMNYLRMVELEG--LTGHIEFNSKGQRSNYALKIL 379

  Fly   380 ELQPSGIVKVGTWD-------EDRQYRPQRLAPTTAQFDSVDNSLANKTFIILLSVPNKPYAQLV 437
            :...:|..::|.|.       :.|.|.           .::.:||.|.|.::...:.| ||..|.
  Rat   380 QFTRNGFRQIGQWHVAEGLSMDSRLYA-----------SNISDSLFNTTLVVTTILEN-PYLMLK 432

  Fly   438 ETYKQLEGNSQYEGYGVDLIKELADKLGFNFTFVNGGNDYGSYNKSTNESTGMLREIMTGRADLA 502
            ..::.:|||.:|||:.||::||||:.|.||:.....|:......::....|||:.|::..:||||
  Rat   433 GNHQDMEGNDRYEGFCVDMLKELAEILRFNYKIRLVGDGVYGVPEANGTWTGMVGELIARKADLA 497

  Fly   503 ITDLTITSEREQALDFTIPFMNLGIAILYLKPQKATPELFTFMDPFSEEVWWFLGFSFLGVSLSF 567
            :..||||:|||:.:||:.|||.|||:|||.......|..|:|:||||..||.|:..::|.||...
  Rat   498 VAGLTITAEREKVIDFSKPFMTLGISILYRVHMGRRPGYFSFLDPFSPGVWLFMLLAYLAVSCVL 562

  Fly   568 FILGRLSPSEWDNPYPCIE-EPEELENQFTLGNSIWFTTGALLQQGSEIGPKALSTRTVASFWWF 631
            |::.||:|.||.:|:||.: ....|.||::||||:||..|..:||||.|.|:|||||.|:..||.
  Rat   563 FLVARLTPYEWYSPHPCAQGRCNLLVNQYSLGNSLWFPVGGFMQQGSTIAPRALSTRCVSGVWWA 627

  Fly   632 FTLIVVSSYTANLAAFLTIEKPQSLINSVDDLADNKDGVVYGAKKTGSTRNFFMTSAEERYKKMN 696
            ||||::||||||||||||:::.:..|.||||||| :..:.||....||:..||..|..:.|::|.
  Rat   628 FTLIIISSYTANLAAFLTVQRMEVPIESVDDLAD-QTAIEYGTIHGGSSMTFFQNSRYQTYQRMW 691

  Fly   697 KFM-SENPQYLTEDNMEGVNRVKTNTHYAFLMESTSIEYNTKRECNLKKIGDALDEKGYGIAMRK 760
            .:| |:.|....:...||:.|| .|::||||:|||..||..:|.|||.:||..||.|||||.|..
  Rat   692 NYMYSKQPSVFVKSTEEGIARV-LNSNYAFLLESTMNEYYRQRNCNLTQIGGLLDTKGYGIGMPV 755

  Fly   761 DWPHRGKFNNALLELQEQGVLEKMKNKWWNEVGTGICATKEDAPDATPLDMNNLEGVFFVLLVGS 825
            ....|.:|:.|:|:|||...||.:|.|||.   .|.|..:|| ..|..|.|.|:.|:|.||:.|.
  Rat   756 GSVFRDEFDLAILQLQENNRLEILKRKWWE---GGKCPKEED-HRAKGLGMENIGGIFVVLICGL 816

  Fly   826 CCALLYGIISWVLFVMKKAHHYRVPLRDALKEEFQFVIDFNNYVRVLKNSASIYSRSRQS 885
            ..|:...::.: |:.::.:....|.:...:..|.:.:|...:         :|:.|.|:|
  Rat   817 IVAIFMAMLEF-LWTLRHSEASEVSVCQEMMTELRSIILCQD---------NIHPRRRRS 866

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIE	NP_001036733.1	PBP1_iGluR_Kainate	42..396	CDD:107377	88/408 (22%)
		ANF_receptor	51..382	CDD:279440	83/370 (22%)
		PBP2_iGluR_Kainate	419..790	CDD:270432	170/372 (46%)
		Lig_chan	551..824	CDD:278489	128/274 (47%)
Grik4	NP_036704.1	Periplasmic_Binding_Protein_type1	24..402	CDD:415822	86/392 (22%)
		PBP2_iGluR_kainate_KA1	415..785	CDD:270442	170/372 (46%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	931..956
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349670
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	1	1.010	-	-		D60688at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.760