DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIE and Grin3a

DIOPT Version :9

Sequence 1:	NP_001036733.1	Gene:	GluRIIE / 318623	FlyBaseID:	FBgn0051201	Length:	897	Species:	Drosophila melanogaster
Sequence 2:	NP_001263284.1	Gene:	Grin3a / 242443	MGIID:	1933206	Length:	1135	Species:	Mus musculus

Alignment Length:	853	Identity:	170/853 - (19%)
Similarity:	331/853 - (38%)	Gaps:	167/853 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    82 DAYQSYGKLCR-MLETGIAGVFG-PSSRHTAVHLMSICDAMDIP------HIYSYMSENAEGFNL 138
            |.:.....:|. ::..|::.:.. |.|:...:.|..:...:.||      |.:...|:|.    |
Mouse   176 DPFSFLQSVCHTVVVQGVSALLAFPQSQGEMMELDLVSSVLHIPVLSIVRHEFPRESQNP----L 236

  Fly   139 H---------PHPADLAKALYSLITEFNW--------------TRFIFLYE--SAEYLNILNELT 178
            |         ...||:.   .|::|..||              |.|:.|.|  |..:|..:..:|
Mouse   237 HLQLSLENSLSSDADVT---VSILTMNNWYNFSLLLCQEDWNITDFLLLTENNSKFHLESIINIT 298

  Fly   179 TMLGKSGTVITVLRYDMQLNGNYKQVLRRVRKSVDNRIVVVGSSETMPEFLNQAQQVGIINEDYK 243
            ..|..:..:::.|:..          |..:|.|....::......::.:....:.|.|:...|..
Mouse   299 ANLSSTKDLLSFLQVQ----------LENIRNSTPTMVMFGCDMGSIRQIFEMSTQFGLSPPDLH 353

  Fly   244 YIIGNLDFHSFDLEEYKYSEANITGLRLFSPEKMAVKELLMKLGYPTDQDEFRNGSCPITVEMAL 308
            :::|:    |.::||.: :|....||........:|.|..::
Mouse   354 WVLGD----SQNVEELR-TEGLPLGLIAHGKTTQSVFEYYVQ----------------------- 390

  Fly   309 TYDAVQLFAQTL-------KNLPFKPMPQNCSQRTESVRDDGSSFKNYMRTLRLTDRLLTGPIYF 366
              ||::|.|:.:       ..|...|...||.....:....|.....::  ...|.|.|:|.|..
Mouse   391 --DAMELVARAVATATMIQPELALLPSTMNCMDVKTTNLTSGQYLSRFL--ANTTFRGLSGSIKV 451

  Fly   367 EGNV----RKGYHLDVIELQPSG---IVKVGTWDEDRQYRPQRLAPTTAQFDSVDNSLANKTFII 424
            :|:.    ...:.:..::..|.|   ..::|:|...|......:.|..||.........||..:.
Mouse   452 KGSTIVSSENNFFIWNLQYDPMGKPMWTRLGSWQGGRIVMDSGIWPEQAQRHKTHFHHPNKLHLR 516

  Fly   425 LLSVPNKPY--------------------------AQLVETYKQLEGNSQ----------YEGYG 453
            ::::...|:                          :.|...:..|..::.          | ||.
Mouse   517 VVTLIEHPFVFTREVDDEGLCPAGQLCLDPMTNDSSILDSLFSSLHSSNDTVPIKFKKCCY-GYC 580

  Fly   454 VDLIKELADKLGFNF-TFVNGGNDYGSYNKSTNESTGMLREIMTGRADLAITDLTITSEREQALD 517
            :||:::||:.:.|:| .::.|...||::  .....||::.::::|.|::|:|..:|.:.|.|.:|
Mouse   581 IDLLEQLAEDMNFDFDLYIVGDGKYGAW--KNGHWTGLVGDLLSGTANMAVTSFSINTARSQVID 643

  Fly   518 FTIPFMNLGIAILYLKPQKATPELFTFMDPFSEEVWWFLG-FSFLGVSLSFFILGRLSPSEWDNP 581
            ||.||.:..:.||......|.| :..||.|....:|  || |..|.::..|..|     .||.:|
Mouse   644 FTSPFFSTSLGILVRTRDTAAP-IGAFMWPLHWTMW--LGIFVALHITAIFLTL-----YEWKSP 700

  Fly   582 YPCIEEPEELENQFTLGNSIWFTTGALLQQGSEI-GPKALSTRTVASFWWFFTLIVVSSYTANLA 645
            :....:.......|:..:::......|..:.:.| .||..:.|.:.:.|..|.:..:|:||||||
Mouse   701 FGMTPKGRNRNKVFSFSSALNVCYALLFGRTAAIKPPKCWTGRFLMNLWAIFCMFCLSTYTANLA 765

  Fly   646 AFLTIEKPQSLINSVDD--LADNKDGVVYGAKKTGSTRNFFMTSAEERYKKMNKF----MSENPQ 704
            |.:..||....::.:.|  |.....|..:|..:..|..::...|..|.::.|.::    ..:..|
Mouse   766 AVMVGEKIYEELSGIHDPKLHHPSQGFRFGTVRESSAEDYVRQSFPEMHEYMRRYNVPATPDGVQ 830

  Fly   705 YLTEDNMEGVNRVKTNTHYAFLMESTSIEYNTK--RECNLKKIGDALDEKGYGIAMRKDWPHRGK 767
            ||..| .|.::        ||:|:...::|...  .:|.|..:|.....:||||.:..:.|....
Mouse   831 YLKND-PEKLD--------AFIMDKALLDYEVSIDADCKLLTVGKPFAIEGYGIGLPPNSPLTSN 886

  Fly   768 FNNALLELQEQGVLEKMKNKWWNEVGTGICATKEDAPDAT-PLDMNNLEGVFFVLLVGSCCALLY 831
            .:..:.:.:..|.::.:.:||:..|.   |..:..|...| .:.:.:..|:|.:|.:|...::|.
Mouse   887 ISELISQYKSHGFMDVLHDKWYKVVP---CGKRSFAVTETLQMGIKHFSGLFVLLCIGFGLSILT 948

  Fly   832 GIISWVLF 839
            .|...:::
Mouse   949 TIGEHIVY 956

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIE	NP_001036733.1	PBP1_iGluR_Kainate	42..396	CDD:107377	62/360 (17%)
		ANF_receptor	51..382	CDD:279440	58/343 (17%)
		PBP2_iGluR_Kainate	419..790	CDD:270432	94/417 (23%)
		Lig_chan	551..824	CDD:278489	63/283 (22%)
Grin3a	NP_001263284.1	PBP1_iGluR_NMDA_NR3	30..497	CDD:107372	63/369 (17%)
		PBP2_iGluR_NMDA_Nr3	512..908	CDD:270438	92/415 (22%)
		Lig_chan	676..942	CDD:278489	63/284 (22%)
		PPP2CB binding site. /evidence=ECO:0000250\|UniProtKB:Q9R1M7	951..987		0/6 (0%)
		GIT1-binding. /evidence=ECO:0000250\|UniProtKB:Q9R1M7	1082..1115
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846385
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740