DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GluRIIE and F59E12.8

DIOPT Version :9

Sequence 1:	NP_001036733.1	Gene:	GluRIIE / 318623	FlyBaseID:	FBgn0051201	Length:	897	Species:	Drosophila melanogaster
Sequence 2:	NP_001364714.1	Gene:	F59E12.8 / 186629	WormBaseID:	WBGene00019123	Length:	379	Species:	Caenorhabditis elegans

Alignment Length:	408	Identity:	87/408 - (21%)
Similarity:	157/408 - (38%)	Gaps:	82/408 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   490 MLREIMTGRADLAITDLTITSEREQALDFTIPF-MNLGIAILYLKPQKATPELFTFMDPFSEEVW 553
            ||.:|..||.|:|.....:|::|...|.||.|. ..:....|...|||:...:|.| .|||..||
Worm     1 MLGDIQKGRIDMACGRFRMTADRANVLTFTYPTQFEVNQVYLITDPQKSVDVVFLF-HPFSTTVW 64

  Fly   554 WFLGFSFLGVSLSFFILGRL---SPSEWDNPYPCIEEPEELENQFTLGNSIWFTTGALLQQGSEI 615
            ..|..:.|.|::.||||..:   |..|.::.|.||:            |||:....:.......:
Worm    65 LLLSLTVLVVAIVFFILRFVEFKSTKETESSYECIQ------------NSIFQVLLSTFNLEIRV 117

  Fly   616 GPKA--LSTRTVASFW---WFFTLIVVSSYTANLAAFLTIEKPQSLINSVDDLADNKDGVVYGAK 675
            ..|:  .:....::.|   ||.  :.:..||:.|:..:.:...:.:      ..||..|.:...:
Worm   118 AKKSTFFAFHLFSTIWLLAWFH--VFIDFYTSELSGMMVVSDKRQV------PFDNFYGFIDHLR 174

  Fly   676 KTGSTRNFFMTSAEERYKKMNKFMSENPQYLTEDNMEGVNRVKTNTH---YAFLMESTSIEYNTK 737
            | |:.|.|  |.:.:|       :.|.|..:|......:.....:.|   |..||:....|:.:.
Worm   175 K-GNYRLF--TPSADR-------IPECPHEITTSKCNAIFSEILSKHPPEYGDLMQLNDREFVSS 229

  Fly   738 RECNLKKIG----DALDEKGYGI-----------------------AMRKDWPHRGKFNNALLEL 775
            |:..|...|    ..:..| :.|                       .:|..:|:..:.|..::::
Worm   230 RKIPLVGFGWYPAQRISSK-FSIWTQELFHSDIWLIRDFPVCPAAYIVRPTFPYLDELNEMIIKV 293

  Fly   776 QEQGVLEKMKNKW---WNEVGTGICATKEDAPDATPLDMNNLEGVFFVLLVGSCCALLYGIISWV 837
            ..  ...::.|.:   :.|:      |....|..:...:|.|..:|.:.|:|:..:.|:.|...|
Worm   294 LP--AFSRIDNHYTPAYPEL------TLTGKPSKSSFSLNQLSSIFLIHLLGAFVSTLFLIAELV 350

  Fly   838 LFVMKKAHHYRVPLRDAL 855
            :..:.|.|:....|:..|
Worm   351 IAELTKRHNIDSTLQTRL 368

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIE	NP_001036733.1	PBP1_iGluR_Kainate	42..396	CDD:107377
		ANF_receptor	51..382	CDD:279440
		PBP2_iGluR_Kainate	419..790	CDD:270432	72/341 (21%)
		Lig_chan	551..824	CDD:278489	57/313 (18%)
F59E12.8	NP_001364714.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810