DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIE and glr-6

DIOPT Version :9

Sequence 1:	NP_001036733.1	Gene:	GluRIIE / 318623	FlyBaseID:	FBgn0051201	Length:	897	Species:	Drosophila melanogaster
Sequence 2:	NP_741822.2	Gene:	glr-6 / 180955	WormBaseID:	WBGene00001617	Length:	844	Species:	Caenorhabditis elegans

Alignment Length:	857	Identity:	226/857 - (26%)
Similarity:	398/857 - (46%)	Gaps:	112/857 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 LESVPIGLLTDQNTEQ-----MNIVFDHAIDVANQEV----------GTSLTSLK---EEVNYGD 82
            :.|:.|||:|..:.|.     :||:    :...|:::          .||..:||   |::|
Worm    17 VSSIRIGLITSHHLEHSVRTAVNII----VPRINEQIVKTRGACFITHTSFIALKNSHEDLN--- 74

  Fly    83 AYQSYGKLCRMLETGIAGVFGPSSRHTAVHLMSICDAMDIPHIY-----SYMSENAEGFNLHPHP 142
                 .|:|.:..:.::.:.|...|.:...:...|..::|..|:     .|..:.....||:| .
Worm    75 -----TKICDLANSEVSVIIGVVDRESGSIIEEQCAELNILFIHYYWTPGYQKKQQTSLNLYP-S 133

  Fly   143 ADLAKALYSLITEFNWTRFIFLYESAEYLNILNELTTMLGKSGTVITVLRYDMQLNGNYKQVLRR 207
            .:.::.:..||..:.|..|:::|.:.:....|.|..:.|.||..::..    ..|:.:.......
Worm   134 MEYSQLMERLINLWRWDNFVYIYSNYDAPKQLIETLSRLEKSPALLRA----HTLDDSMMATALA 194

  Fly   208 VRKSVD--------NRIVV-VGSSETMPEFLNQAQQVGIINEDYKYIIGNLDFHSFDLEEYKYSE 263
            :|.:.|        ||::: :..:||: .|.:.:.::|:|:....::|..||..:..|.:|.::.
Worm   195 LRDTCDRNRCWPKKNRVLIELSPNETL-TFFDASLKLGMISVHNWFLITALDDLNDHLSQYTHNG 258

  Fly   264 ANITGLRLFSPEKMAVKELLMKLGYPTDQDEF-----RNGSCPITVEMALTYDAVQLFAQTLKNL 323
            ..:: |...|.||....:|.:||  |....|:     .|...|.. :.|..:|::.|..|
Worm   259 MRVS-LLTVSKEKWNQNDLAIKL--PDMYQEYLAKIPSNPRTPFK-DFAFIFDSILLACQ----- 314

  Fly   324 PFKPMPQNCSQRTESVRDDGSSFKNYMRTLRLTDRLLTGPIYFEG-NVRKGYHLDVIELQPSGIV 387
                    ...|......|..:.|.:...:....:.|||.|.|.| :.|....|.:.|:   ||.
Worm   315 --------AGDRRIISCGDNEAVKKFKLPIVKPFKGLTGKISFNGTSDRSDSELHIWEM---GIT 368

  Fly   388 KVG--------TWDEDRQYR--PQRLAPTTAQFDSVDNSLANKTFIILLSVPNKPYAQLVETYKQ 442
            ..|        ||:..::..  .:.:..|...:.:   |:.....:.:.|:..|||  ::|....
Worm   369 GAGLHTGIWKSTWEGSKELTMLAKNIPGTHEHYQA---SVRESRTLKVTSIHEKPY--VIEKIMP 428

  Fly   443 LEGNSQYEGYGVDLIKELADKLGFNFTF-VNGGNDYGSYNKSTNESTGMLREIMTGRADLAITDL 506
             :|..::||:.|||:.:||:.|.||:|. :...|.||.....|:|..||:.||:.|.||:|:..:
Worm   429 -DGRIKHEGFCVDLLDKLAEMLHFNYTLKIVKDNKYGERKNGTDEWDGMIGEILRGDADMAVAPI 492

  Fly   507 TITSEREQALDFTIPFMNLGIAILYLKPQ-KATPELFTFMDPFSEEVWWFLGFSFLGVSLSFFIL 570
            |:|:.|.:.:|||.||:.|||::|..:|. |::..|..|:.|.|..||.|...:.:..:|...:.
Worm   493 TVTATRLEVIDFTDPFLQLGISMLMRQPNPKSSSSLTRFLWPLSASVWTFSAIATVITALLVTVA 557

  Fly   571 GRLSPSEWDNPYPCIEEPEELENQFTLGNSIWFTTGALLQQGSEIGPKALSTRTVASFWWFFTLI 635
            ..||             |:|...:|.:.||:|:....||:.||....:|.:||.:::.||.|||:
Worm   558 AVLS-------------PKESTAEFKIQNSVWYLVCILLRAGSGYNCQAGATRLISAVWWSFTLV 609

  Fly   636 VVSSYTANLAAFLTIEKPQSLINSVDDLADNKDGVVYGAKKTGSTRNFFMTSAEERYKKM-NKFM 699
            :::.||||.||.||:::.....||.::|. |:....:|:...|||..||..|..|.:::: .:..
Worm   610 LIAQYTANFAALLTVDRKSMPFNSFEELG-NQTEYNFGSILGGSTMQFFKYSRIETFRRLWERMQ 673

  Fly   700 SENPQYLTEDNMEGVNRVKTNTHYAFLMESTSIEYNTKRECNLKKIGD-ALDEKGYGIAMRKDWP 763
            |..|......|.|||||| .|..|.|||||.:::|...:.|||.::|: .|...||.||:.|...
Worm   674 SAEPSAFVGTNHEGVNRV-LNEKYVFLMESATLDYQVTQNCNLTRVGNVVLGSNGYSIALPKGSK 737

  Fly   764 HRGKFNNALLELQEQGVLEKMKNKWWNEVGTGICATKEDAPDATPLDMNNLEGVFFVLLVGSCCA 828
            .|.|....:|:|.|:|::..:||.||.: ....|.:.|.....|.|...|:.|:|.:|.:||...
Worm   738 WREKLTRQILDLNEKGIILMLKNNWWKK-SQQECQSSEPEDLQTALGAENVYGLFLLLALGSGIG 801

  Fly   829 LLYGIISWVLFV 840
            :|..::....|:
Worm   802 VLCAVLEHTHFI 813

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIE	NP_001036733.1	PBP1_iGluR_Kainate	42..396	CDD:107377	81/399 (20%)
		ANF_receptor	51..382	CDD:279440	72/368 (20%)
		PBP2_iGluR_Kainate	419..790	CDD:270432	128/374 (34%)
		Lig_chan	551..824	CDD:278489	89/274 (32%)
glr-6	NP_741822.2	PBP1_iGluR_non_NMDA-like	21..394	CDD:380591	82/410 (20%)
glr-6	NP_741822.2	PBP2_iGluR_Kainate	409..764	CDD:270432	128/372 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D60688at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.020